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Molecular mechanisms of vascular calcification in diabetes mellitus: insights from human aortic smooth muscle cells, a systematic review

Heart Science Journal · Vol. 7 No. 1 (2026) · hlm. 4–10

DOI
10.21776/ub.hsj.2026.007.01.2
ISSN
2721-9984, 2721-9976
Terbit
2026-01-31
Penerbit
Universitas Brawijaya
Bahasa
en
Lisensi
creativecommons.org/licenses/by/4.0

Abstrak

Background: Vascular calcification is a significant contributor to cardiovascular complications in diabetes mellitus (DM), particularly affecting the prognosis of patients. Objectives: To conduct a comprehensive analysis of the molecular mechanisms underlying vascular calcification in DM, with a focus on insights from human aortic smooth muscle cells (HASMCs). Methods: The search was conducted following the PRISMA guidelines, utilizing databases such as MEDLINE/PubMed, Science Direct, and Google Scholar. The search focused on articles published within the last 5 years that discussed the molecular mechanisms of vascular calcification in DM, specifically in HASMCs. Results: Five selected reviews were found in a total of 637 articles. DM significantly accelerates vascular calcification in HASMCs through the upregulation of osteogenic markers and activation of the Wnt/β-catenin signaling pathway. Other identified mechanisms include inflammation, ferroptosis, and endothelial dysfunction, contributing to the complex interplay of factors that drive vascular calcification in diabetic patients. Conclusion: It is concluded that DM significantly accelerates vascular calcification in enhanced expression of osteogenic markers and activation of the Wnt/β-catenin signaling pathway in human aortic smooth muscle cells. Patients with diabetes are more likely to have cardiovascular issues as a result of this pathological process.

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  • University of Brawijaya
  • State University of Malang
  • Udayana University
  • RSUD Prof. Dr. Saiful Anwar Malang
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Rekan penulisOrganisasiArtikel bersama
Anna Fuji RahimahUniversity of Brawijaya18
Cholid Tri TjahjonoUniversity of Brawijaya18
Ardian RizalUniversity of Brawijaya18
Budi SatrijoUniversity of Brawijaya17
Indra PrasetyaUniversity of Brawijaya17
Setyasih AnjarwaniUniversity of Brawijaya16
Novi KurnianingsihUniversity of Brawijaya13
Yoga WaranugrahaUniversity of Brawijaya10
Djanggan SargowoUniversity of Brawijaya9
Sasmojo WiditoUniversity of Brawijaya9
Heny MartiniUniversity of Brawijaya9
Adhika Prastya WikanandaUniversity of Brawijaya4
Tri AstiawatiUniversity of Brawijaya4
Putri Annisa KamilaUniversity of Brawijaya3
Dadang HendrawanUniversity of Brawijaya3
Muhammad Rizki FadlanUniversity of Brawijaya3
Fandy HazzyUniversity of Brawijaya3
Wella KarolinaUniversity of Brawijaya3
Hayla Iqda MillisaniUniversity of Brawijaya3
Oktivani Adelathifa RahmaUniversity of Brawijaya3
Jonny Karunia FajarUniversity of Brawijaya3
Veny KurniawatiUniversity of Brawijaya2
Tonny AdriyantoUniversity of Brawijaya2
Olivia HandayaniUniversity of Brawijaya2
Fahmy RusnantaUniversity of Brawijaya2
Fitranti Suciati LaitupaUniversity of Brawijaya2
Oktafin Srywati PamunaUniversity of Brawijaya2
Anna Fuji RahimahAfiliasi tidak diketahui2
Imelda KrisnasariUniversity of Brawijaya2
Ratna PancasariUniversity of Brawijaya2
Ayu Asri Devi AdityawatiUniversity of Brawijaya2
Hidayat SujutiUniversity of Brawijaya2

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Sumber metadata: OAI-PMH (metadata jurnal) https://heartscience.ub.ac.id/index.php/heartscience/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Molecular mechanisms of vascular calcification in diabetes mellitus: insights from human aortic smooth muscle cells, a systematic review</dc:title>
	<dc:creator xml:lang="en">Weningtyas, Anditri</dc:creator>
	<dc:creator xml:lang="en">Rohman, Mohammad Saifur</dc:creator>
	<dc:creator xml:lang="en">Chomsy, Indah Nur</dc:creator>
	<dc:creator xml:lang="en">Hose, Victor Alvianoes Guterez</dc:creator>
	<dc:creator xml:lang="en">Riza, Mochamad Faishal</dc:creator>
	<dc:creator xml:lang="en">Purbaningroom, Dian Laila</dc:creator>
	<dc:creator xml:lang="en">Rudijanto, Achmad</dc:creator>
	<dc:creator xml:lang="en">Nugrahenny, Dian</dc:creator>
	<dc:subject xml:lang="en">Aortic Smooth Muscle</dc:subject>
	<dc:subject xml:lang="en">Diabetes Mellitus</dc:subject>
	<dc:subject xml:lang="en">Molecular Mechanism</dc:subject>
	<dc:subject xml:lang="en">Vascular Calcification</dc:subject>
	<dc:description xml:lang="en">Background: Vascular calcification is a significant contributor to cardiovascular complications in diabetes mellitus (DM), particularly affecting the prognosis of patients.  
Objectives: To conduct a comprehensive analysis of the molecular mechanisms underlying vascular calcification in DM, with a focus on insights from human aortic smooth muscle cells (HASMCs).
Methods: The search was conducted following the PRISMA guidelines, utilizing databases such as MEDLINE/PubMed, Science Direct, and Google Scholar. The search focused on articles published within the last 5 years that discussed the molecular mechanisms of vascular calcification in DM, specifically in HASMCs.
Results: Five selected reviews were found in a total of 637 articles. DM significantly accelerates vascular calcification in HASMCs through the upregulation of osteogenic markers and activation of the Wnt/β-catenin signaling pathway. Other identified mechanisms include inflammation, ferroptosis, and endothelial dysfunction, contributing to the complex interplay of factors that drive vascular calcification in diabetic patients.
Conclusion: It is concluded that DM significantly accelerates vascular calcification in enhanced expression of osteogenic markers and activation of the Wnt/β-catenin signaling pathway in human aortic smooth muscle cells. Patients with diabetes are more likely to have cardiovascular issues as a result of this pathological process.</dc:description>
	<dc:publisher xml:lang="en">Universitas Brawijaya</dc:publisher>
	<dc:date>2026-01-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://heartscience.ub.ac.id/index.php/heartscience/article/view/20224</dc:identifier>
	<dc:identifier>10.21776/ub.hsj.2026.007.01.2</dc:identifier>
	<dc:source xml:lang="en">Heart Science Journal; Vol. 7 No. 1 (2026): Accelerating Clinical Breakthroughs: The Journey from Molecular Discovery to Patient Care; 4-10</dc:source>
	<dc:source>2721-9984</dc:source>
	<dc:source>2721-9976</dc:source>
	<dc:source>10.21776/ub.hsj.2026.007.01</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://heartscience.ub.ac.id/index.php/heartscience/article/view/20224/551</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2026 Anditri Weningtyas, Mohammad Saifur Rohman, Indah Nur Chomsy, Victor Alvianoes Guterez Hose, Mochamad Faishal Riza, Dian Laila Purbaningroom, Achmad Rudijanto, Dian Nugrahenny</dc:rights>
	<dc:rights xml:lang="en">http://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>