The effect of exercise training as adjuvant treatment on mean pulmonary arterial pressure by echocardiography and functional capacity in congenital heart disease with negative vaso reactivity test pulmonary hypertension patient at Saiful Anwar Hospital Malang

Firdaus, Muhammad; Heny Martini; Wella Karolina; Valerinna Yogibuana; Cholid Tri Tjahjono

doi:10.21776/ub.hsj.2025.006.02.13

Akses terbuka Jurnal SINTA 1

The effect of exercise training as adjuvant treatment on mean pulmonary arterial pressure by echocardiography and functional capacity in congenital heart disease with negative vaso reactivity test pulmonary hypertension patient at Saiful Anwar Hospital Malang

Heart Science Journal · Vol. 6 No. 2 (2025)

DOI: 10.21776/ub.hsj.2025.006.02.13
ISSN: 2721-9984, 2721-9976
Terbit: 2025-04-30
Penerbit: Universitas Brawijaya
Bahasa: en
Lisensi: creativecommons.org/licenses/by/4.0

Abstrak

Background: PH is defined by mPAP >20 mmHg at rest. Exercise training enhances hemodynamics and exercise capacity in PH patients. Echocardiography is essential for assessing and evaluating PAP in PH cases. Objective: This study aims to determine the effect of 12-weel exercise training on mPAP by echocardiography and functional capacity Methods: A prospective cohort study at Saiful Anwar General Hospital (Sept 2024-Jan 2025) investigated exercise effects on mPAP and functional capacity in pulmonary hypertension patients. Participants were randomized to control (medication only) or treatment (medication plus exercise training) groups. Both underwent SMWT and echocardiography at baseline and after 12 weeks. Standardized exercise was monitored by healthcare experts. Result: This study compared 12 non-vasoreactive PH patients receiving standard therapy to 12 undergoing exercise training. The treatment group showed a significant mPAP decrease (66.8 to 63.4 mmHg, p=0.006), while the control group's reduction was non-significant (53.1 to 51.7 mmHg, p=0.061). Both groups improved 6MWT distances significantly after 12 weeks from 306.5 ± 72.7 meters to 318.3 ± 74.0 meters in the control group (p=0.041) and from 363.8 ± 63.6 meters to 382.9 ± 64.7 meters in the treatment group (p=0.000). No significant correlation was found between mPAP decrease and 6MWT increase in either group Conclusion: This study demonstrates improvements in mPAP and functional capacity following exercise training as an adjunctive therapy. However, no correlation was observed between the enhancement in functional capacity and the reduction in mPAP.

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University of Brawijaya
RSUD Prof. Dr. Saiful Anwar Malang
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Rekan penulis	Organisasi	Artikel bersama
Mohammad Saifur Rohman	University of Brawijaya	32
Anna Fuji Rahimah	University of Brawijaya	29
Indra Prasetya	University of Brawijaya	20
Novi Kurnianingsih	University of Brawijaya	19
Ardian Rizal	University of Brawijaya	17
Setyasih Anjarwani	University of Brawijaya	14
Sasmojo Widito	University of Brawijaya	12
Djanggan Sargowo	University of Brawijaya	11
Budi Satrijo	University of Brawijaya	11
Yoga Waranugraha	University of Brawijaya	6
Valerinna Yogibuana Swastika Putri	University of Brawijaya	5
Muhammad Rizki Fadlan	University of Brawijaya	4
Saskia Dyah Handari	University of Brawijaya	4
Zainal Fathurohim	University of Brawijaya	4
Dadang Hendrawan	University of Brawijaya	3
Ratna Pancasari	University of Brawijaya	3
Ayu Asri Devi Adityawati	University of Brawijaya	3
Seprian Widasmara	University of Brawijaya	3
Arif Ranu Wicaksono	University of Brawijaya	3
Ardhani Galih	RSUD Prof. Dr. Saiful Anwar Malang	3
Achmad Jauhar Firdaus	RSUD Prof. Dr. Saiful Anwar Malang	3
Pawik Supriadi	University of Brawijaya	3
Wira Kimahesa	University of Brawijaya	3
Akhmad Isna Nurudinulloh	University of Brawijaya	3
Tonny Adriyanto	University of Brawijaya	2
Anna Fuji Rahimah	Afiliasi tidak diketahui	2
Evit Ruspiono	Afiliasi tidak diketahui	2
Ardani Galih Prakosa	RSUD Prof. Dr. Saiful Anwar Malang	2
Titin Andri Wihastuti	University of Brawijaya	2
Lukitasari Ayu Galuh Ardhi	University of Brawijaya	2
Oktafin Srywati Pamuna	University of Brawijaya	2
Adhika Prastya Wikananda	University of Brawijaya	2
Iskandar Iskandar	University of Brawijaya	2
Dea Arie Kurniawan	University of Brawijaya	2
Tria Yudha Nugraha	University of Brawijaya	2

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Sumber metadata: OAI-PMH (metadata jurnal) https://heartscience.ub.ac.id/index.php/heartscience/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.

Metadata asli (oai_dc)

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	<dc:title xml:lang="en">The effect of exercise training as adjuvant treatment on mean pulmonary arterial pressure by echocardiography and functional capacity in congenital heart disease with negative vaso reactivity test pulmonary hypertension patient at Saiful Anwar Hospital Malang</dc:title>
	<dc:creator xml:lang="en">Firdaus, Muhammad</dc:creator>
	<dc:creator xml:lang="en">Heny Martini</dc:creator>
	<dc:creator xml:lang="en">Wella Karolina</dc:creator>
	<dc:creator xml:lang="en">Valerinna Yogibuana</dc:creator>
	<dc:creator xml:lang="en">Cholid Tri Tjahjono</dc:creator>
	<dc:subject xml:lang="en">Echocardiography</dc:subject>
	<dc:subject xml:lang="en">Exercise Training</dc:subject>
	<dc:subject xml:lang="en">Pulmonary Hypertension</dc:subject>
	<dc:subject xml:lang="en">Six Minutes Walking Test</dc:subject>
	<dc:description xml:lang="en">



 
Background : PH is defined by mPAP &amp;gt;20 mmHg at rest. Exercise training enhances hemodynamics and exercise capacity in PH patients. Echocardiography is essential for assessing and evaluating PAP in PH cases.
Objective : This study aims to determine the effect of 12-weel exercise training on mPAP by echocardiography and functional capacity
Methods : A prospective cohort study at Saiful Anwar General Hospital (Sept 2024-Jan 2025) investigated exercise effects on mPAP and functional capacity in pulmonary hypertension patients. Participants were randomized to control (medication only) or treatment (medication plus exercise training) groups. Both underwent SMWT and echocardiography at baseline and after 12 weeks. Standardized exercise was monitored by healthcare experts.
Result : This study compared 12 non-vasoreactive PH patients receiving standard therapy to 12 undergoing exercise training. The treatment group showed a significant mPAP decrease (66.8 to 63.4 mmHg, p=0.006), while the control group's reduction was non-significant (53.1 to 51.7 mmHg, p=0.061). Both groups improved 6MWT distances significantly after 12 weeks from 306.5 ± 72.7 meters to 318.3 ± 74.0 meters in the control group (p=0.041) and from 363.8 ± 63.6 meters to 382.9 ± 64.7 meters in the treatment group (p=0.000). No significant correlation was found between mPAP decrease and 6MWT increase in either group
Conclusion : This study demonstrates improvements in mPAP and functional capacity following exercise training as an adjunctive therapy. However, no correlation was observed between the enhancement in functional capacity and the reduction in mPAP.
 



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	<dc:publisher xml:lang="en">Universitas Brawijaya</dc:publisher>
	<dc:date>2025-04-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://heartscience.ub.ac.id/index.php/heartscience/article/view/20316</dc:identifier>
	<dc:identifier>10.21776/ub.hsj.2025.006.02.13</dc:identifier>
	<dc:source xml:lang="en">Heart Science Journal; Vol. 6 No. 2 (2025): The Complexity in the Management of Heart Rhythm Disorder</dc:source>
	<dc:source>2721-9984</dc:source>
	<dc:source>2721-9976</dc:source>
	<dc:source>10.21776/ub.hsj.2025.006.02</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://heartscience.ub.ac.id/index.php/heartscience/article/view/20316/496</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Muhammad Firdaus, Heny Martini, wella Karolina, Valerinna Yogibuana, Cholid Tri Tjahjono</dc:rights>
	<dc:rights xml:lang="en">http://creativecommons.org/licenses/by/4.0</dc:rights>
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