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Impact of supervised physical activity as adjunctive therapy on functional capacity and NT-pro BNP in patients with negative-reactivity test pulmonary hypertension related to congenital heart disease patient in Saiful Anwar Hospital Malang: A preliminary study

Heart Science Journal · Vol. 6 No. 4 (2025)

DOI
10.21776/ub.hsj.2025.006.04.10
ISSN
2721-9984, 2721-9976
Terbit
2025-10-31
Penerbit
Universitas Brawijaya
Bahasa
en
Lisensi
creativecommons.org/licenses/by/4.0

Abstrak

Background: Appropriate levels of physical activity (PhA) provide health benefits to patients with chronic diseases, including patients with pulmonary hypertension-related to congenital heart disease (CHD-PH), representing around 4-10% of all PH patients. Objective: The purpose of this analysis was to determine the benefits and effectiveness of PhA as an additional therapy to optimal medication vs. control group on the functional capacity and N-terminal prohormone of B-type natriuretic peptide (NT-pro BNP) in patients with inoperable CHD-PH. Methods: A clinical preliminary study was conducted with 26 consecutive patients in stable condition before the study. Each patient was educated about the benefits of PhA and efficacy parameters of the six-minute walking distance (6MWD) and NT-Pro BNP levels have been evaluated at baseline and after 12 weeks. Results: The study included participants aged 33 ± 11 years, 84% of whom were female. All patients tolerated PhA without severe adverse events. Patients significantly improved the mean 6MWD compared to baseline by 382.9 ± 64.7 (p=0,000) and 318.3 ± 74 (p=0,041) meters after 12 weeks (training vs. control group). Ln NT-pro BNP improved significantly in the training group (p=0,002). There were no differences at week 12 in the delta 6MWD and NT-pro BNP levels, with all P values >0,05. Likewise, there is no correlation between the two variables Conclusions: PhA as an add-on to medical therapy may enhance work capacity and other prognostic relevant parameters in patients with inoperable CHD-PH. However, further larger, multi-center randomized controlled trials, is warranted to validate these preliminary findings

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  • University of Brawijaya
  • RSUD Prof. Dr. Saiful Anwar Malang
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
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Rekan penulisOrganisasiArtikel bersama
Mohammad Saifur RohmanUniversity of Brawijaya47
Anna Fuji RahimahUniversity of Brawijaya33
Setyasih AnjarwaniUniversity of Brawijaya30
Novi KurnianingsihUniversity of Brawijaya24
Ardian RizalUniversity of Brawijaya23
Budi SatrijoUniversity of Brawijaya19
Sasmojo WiditoUniversity of Brawijaya14
Djanggan SargowoUniversity of Brawijaya13
Wella KarolinaUniversity of Brawijaya12
Tria Yudha NugrahaUniversity of Brawijaya6
Yoga WaranugrahaUniversity of Brawijaya5
Muhammad Rizki FadlanUniversity of Brawijaya5
Saskia Dyah HandariUniversity of Brawijaya5
Seprian WidasmaraUniversity of Brawijaya5
Valerinna Yogibuana Swastika PutriUniversity of Brawijaya5
Ratna PancasariUniversity of Brawijaya4
Ayu Asri Devi AdityawatiUniversity of Brawijaya4
Zainal FathurohimUniversity of Brawijaya4
Akhmad Isna NurudinullohUniversity of Brawijaya4
Hayla Iqda MillisaniUniversity of Brawijaya3
Putri Annisa KamilaUniversity of Brawijaya3
Dadang HendrawanUniversity of Brawijaya3
Anna Fuji RahimahAfiliasi tidak diketahui3
Arif Ranu WicaksonoUniversity of Brawijaya3
Lutfi Hafiz ZunardiUniversity of Brawijaya3
Teguh AryanugrahaUniversity of Brawijaya3
Oktafin Srywati PamunaUniversity of Brawijaya3
Fahmy RusnantaUniversity of Brawijaya3
Tonny AdriyantoUniversity of Brawijaya2
Taufieq Ridlo MakhmudUniversity of Brawijaya2
Faris Wahyu NugrohoUniversity of Brawijaya2
Liemena Harold AdrianRSUD Prof. Dr. Saiful Anwar Malang2
Adhika Prastya WikanandaUniversity of Brawijaya2
Iskandar IskandarUniversity of Brawijaya2
Imelda KrisnasariUniversity of Brawijaya2

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) https://heartscience.ub.ac.id/index.php/heartscience/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Impact of supervised physical activity as adjunctive therapy on functional capacity and NT-pro BNP in patients with negative-reactivity test pulmonary hypertension related to congenital heart disease patient in Saiful Anwar Hospital Malang : A preliminary study</dc:title>
	<dc:creator xml:lang="en">Setyowati, Danti Utami</dc:creator>
	<dc:creator xml:lang="en">Martini, Heny</dc:creator>
	<dc:creator xml:lang="en">Prasetya, Indra</dc:creator>
	<dc:creator xml:lang="en">Tjahjono, Cholid Tri</dc:creator>
	<dc:creator xml:lang="en">Yogibuana, Valerinna</dc:creator>
	<dc:subject xml:lang="en">Pulmonary Hypertension</dc:subject>
	<dc:subject xml:lang="en">Physical Activity</dc:subject>
	<dc:subject xml:lang="en">6MWD</dc:subject>
	<dc:subject xml:lang="en">NT-Pro BNP</dc:subject>
	<dc:description xml:lang="en">Background: Appropriate levels of physical activity (PhA) provide health benefits to patients with chronic diseases, including patients with pulmonary hypertension-related to congenital heart disease (CHD-PH), representing around 4-10% of all PH patients.
Objective: The purpose of this analysis was to determine the benefits and effectiveness of PhA as an additional therapy to optimal medication vs. control group on the functional capacity and N-terminal prohormone of B-type natriuretic peptide (NT-pro BNP) in patients with inoperable CHD-PH.
Methods: A clinical preliminary study was conducted with 26 consecutive patients in stable condition before the study. Each patient was educated about the benefits of PhA and efficacy parameters of the six-minute walking distance (6MWD) and NT-Pro BNP levels have been evaluated at baseline and after 12 weeks.
Results: The study included participants aged 33 ± 11 years, 84% of whom were female. All patients tolerated PhA without severe adverse events. Patients significantly improved the mean 6MWD compared to baseline by 382.9 ± 64.7 (p=0,000) and 318.3 ± 74 (p=0,041) meters after 12 weeks (training vs. control group). Ln NT-pro BNP improved significantly in the training group (p=0,002). There were no differences at week 12 in the delta 6MWD and NT-pro BNP levels, with all P values &amp;gt;0,05. Likewise, there is no correlation between the two variables
Conclusions: PhA as an add-on to medical therapy may enhance work capacity and other prognostic relevant parameters in patients with inoperable CHD-PH. However, further larger, multi-center randomized controlled trials, is warranted to validate these preliminary findings</dc:description>
	<dc:publisher xml:lang="en">Universitas Brawijaya</dc:publisher>
	<dc:date>2025-10-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://heartscience.ub.ac.id/index.php/heartscience/article/view/20324</dc:identifier>
	<dc:identifier>10.21776/ub.hsj.2025.006.04.10</dc:identifier>
	<dc:source xml:lang="en">Heart Science Journal; Vol. 6 No. 4 (2025): The Pursuit of Precision: Navigating Risks, Refining Diagnosis, and Securing Long-Term Vascular Outcomes in Contemporary Cardiovascular Practice</dc:source>
	<dc:source>2721-9984</dc:source>
	<dc:source>2721-9976</dc:source>
	<dc:source>10.21776/ub.hsj.2025.006.04</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://heartscience.ub.ac.id/index.php/heartscience/article/view/20324/540</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Danti Utami Setyowati, Heny Martini, Indra Prasetya, Cholid Tri Tjahjono, Valerinna Yogibuana</dc:rights>
	<dc:rights xml:lang="en">http://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>