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Cardioprotective effects of colchicine: Targeting pyroptosis and inflammation in myocardial infarction

Heart Science Journal · Vol. 6 No. 2 (2025)

DOI
10.21776/ub.hsj.2025.006.02.8
ISSN
2721-9984, 2721-9976
Terbit
2025-04-30
Penerbit
Universitas Brawijaya
Bahasa
en
Lisensi
creativecommons.org/licenses/by/4.0

Abstrak

Myocardial infarction (MI) is a significant contributor to global morbidity and mortality. The outcome of MI is associated with the inflammatory response triggered by ischemic or necrotic cells. Pyroptosis is a type of programmed cell death that can exacerbate cardiac injury following MI. This study reviewed the potential therapeutic effects of colchicine in regulating cardiac pyroptosis in response to MI. Primarily, colchicine inhibits tubulin polymerization and microtubule formation, disrupting inflammasome advancement and the subsequent secretion of various pro-inflammatory mediators. In particular, colchicine disrupts the NLRP3 inflammasome assembly process by blocking ASC recruitment into the complex, suggesting its potential to mitigate the inflammatory response related to cardiac pyroptosis. Additionally, colchicine binds to P2X7 receptors, reducing ATP-induced microtubule and pore formation, which attenuates reactive oxygen species and IL-1β production. A clinical trial involving colchicine showed positive outcomes in lowering the occurrence of major cardiovascular events in individuals with coronary artery disease (CAD). Nonetheless, additional studies are required to ascertain the ideal dosage, timing, and long-term effects of colchicine in the infarcted myocardium before it can be routinely recommended for post-MI treatment. In conclusion, colchicine's modulation of the inflammatory response and inhibition of pyroptosis highlight its potential as a cardioprotective agent for MI management.

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Rekan penulisOrganisasiArtikel bersama
Cholid Tri TjahjonoUniversity of Brawijaya26
Indra PrasetyaUniversity of Brawijaya25
Setyasih AnjarwaniUniversity of Brawijaya25
Anna Fuji RahimahUniversity of Brawijaya23
Ardian RizalUniversity of Brawijaya21
Novi KurnianingsihUniversity of Brawijaya19
Djanggan SargowoUniversity of Brawijaya16
Sasmojo WiditoUniversity of Brawijaya16
Yoga WaranugrahaUniversity of Brawijaya12
Heny MartiniUniversity of Brawijaya11
Muhammad Rizki FadlanUniversity of Brawijaya6
Putri Annisa KamilaUniversity of Brawijaya5
Adhika Prastya WikanandaUniversity of Brawijaya4
Tri AstiawatiUniversity of Brawijaya4
Dadang HendrawanUniversity of Brawijaya4
Hayla Iqda MillisaniUniversity of Brawijaya4
Fandy HazzyUniversity of Brawijaya3
Wella KarolinaUniversity of Brawijaya3
Oktivani Adelathifa RahmaUniversity of Brawijaya3
Jonny Karunia FajarUniversity of Brawijaya3
Olivia HandayaniUniversity of Brawijaya3
Dea Arie KurniawanUniversity of Brawijaya3
Ayu Asri Devi AdityawatiUniversity of Brawijaya3
Seprian WidasmaraUniversity of Brawijaya3
Valerinna YogibuanaAfiliasi tidak diketahui3
Valerinna Yogibuana Swastika PutriUniversity of Brawijaya3
Shalahuddin Suryo BaskoroUniversity of Brawijaya3
Nikhen NoverikeUniversity of Brawijaya3
Zhafran VeliawanUniversity of Brawijaya3
Veny KurniawatiUniversity of Brawijaya2
Tonny AdriyantoUniversity of Brawijaya2
Fahmy RusnantaUniversity of Brawijaya2
Fitranti Suciati LaitupaUniversity of Brawijaya2
Dian NugrahennyUniversity of Brawijaya2

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Sumber metadata: OAI-PMH (metadata jurnal) https://heartscience.ub.ac.id/index.php/heartscience/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Cardioprotective effects of colchicine: Targeting pyroptosis and inflammation in myocardial infarction</dc:title>
	<dc:creator xml:lang="en">Satrijo, Budi</dc:creator>
	<dc:creator xml:lang="en">Mohammad Saifur Rohman</dc:creator>
	<dc:creator xml:lang="en">Aulanni'am Aulanni'am</dc:creator>
	<dc:creator xml:lang="en">Hidayat Sujuti </dc:creator>
	<dc:creator xml:lang="en">Bayu Lestari</dc:creator>
	<dc:creator xml:lang="en">Rislan Faiz Muhammad</dc:creator>
	<dc:subject xml:lang="en">Colchicine</dc:subject>
	<dc:subject xml:lang="en">Pyroptosis</dc:subject>
	<dc:subject xml:lang="en">Inflammation</dc:subject>
	<dc:subject xml:lang="en">Myocardial Infarction</dc:subject>
	<dc:subject xml:lang="en">NLRP3 Inflammasome</dc:subject>
	<dc:description xml:lang="en">Myocardial infarction (MI) is a significant contributor to global morbidity and mortality. The outcome of MI is associated with the inflammatory response triggered by ischemic or necrotic cells. Pyroptosis is a type of programmed cell death that can exacerbate cardiac injury following MI. This study reviewed the potential therapeutic effects of colchicine in regulating cardiac pyroptosis in response to MI. Primarily, colchicine inhibits tubulin polymerization and microtubule formation, disrupting inflammasome advancement and the subsequent secretion of various pro-inflammatory mediators. In particular, colchicine disrupts the NLRP3 inflammasome assembly process by blocking ASC recruitment into the complex, suggesting its potential to mitigate the inflammatory response related to cardiac pyroptosis. Additionally, colchicine binds to P2X7 receptors, reducing ATP-induced microtubule and pore formation, which attenuates reactive oxygen species and IL-1β production. A clinical trial involving colchicine showed positive outcomes in lowering the occurrence of major cardiovascular events in individuals with coronary artery disease (CAD). Nonetheless, additional studies are required to ascertain the ideal dosage, timing, and long-term effects of colchicine in the infarcted myocardium before it can be routinely recommended for post-MI treatment. In conclusion, colchicine's modulation of the inflammatory response and inhibition of pyroptosis highlight its potential as a cardioprotective agent for MI management.</dc:description>
	<dc:publisher xml:lang="en">Universitas Brawijaya</dc:publisher>
	<dc:date>2025-04-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://heartscience.ub.ac.id/index.php/heartscience/article/view/20375</dc:identifier>
	<dc:identifier>10.21776/ub.hsj.2025.006.02.8</dc:identifier>
	<dc:source xml:lang="en">Heart Science Journal; Vol. 6 No. 2 (2025): The Complexity in the Management of Heart Rhythm Disorder</dc:source>
	<dc:source>2721-9984</dc:source>
	<dc:source>2721-9976</dc:source>
	<dc:source>10.21776/ub.hsj.2025.006.02</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://heartscience.ub.ac.id/index.php/heartscience/article/view/20375/491</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Budi Satrijo, Mohammad Saifur Rohman, Aulanni'am Aulanni'am, Hidayat Sujuti , Bayu Lestari, Rislan Faiz Muhammad</dc:rights>
	<dc:rights xml:lang="en">http://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>