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Effect of decaffeinated green tea and green coffee combination on improving blood glucose levels in metabolic syndrome patients

Heart Science Journal · Vol. 7 No. 1 (2026) · hlm. 68–72

DOI
10.21776/ub.hsj.2026.007.01.12
ISSN
2721-9984, 2721-9976
Terbit
2026-01-31
Penerbit
Universitas Brawijaya
Bahasa
en
Lisensi
creativecommons.org/licenses/by/4.0

Abstrak

Background: Metabolic syndrome (MS) contributes to high mortality and morbidity not only in developing countries but also in developed countries, with central obesity and insulin resistance as primary risk factors. Our previous study demonstrated that combined decaffeinated green tea and green coffee extracts more effectively improved lipid and glucose profiles in an MS rat model. Objective: This study evaluates the efficacy of the extracts on top guideline-directed medical treatment optimal therapy in metabolic syndrome patients. Methods: The study was a randomized controlled trial (RCT) involving 90 patients diagnosed with metabolic syndrome, ages 45-70. Participants were randomly sorted into three groups: the first group received 2x2.5 g, the second group received 1x5 g, and the third one received a placebo. Researchers measured baseline and final values for fasting blood glucose (FBG), post-meal glucose levels (PPBG), and glycated hemoglobin (HbA1C) to evaluate treatment effects. Result: After 90 days of treatment with decaffeinated green tea and green coffee combination, both experimental groups (Groups 1 and 2) revealed significant decreases in PPBG and HbA1c compared to the control group. (-14.10 ± 2.00 vs. -28.63 ± 4.61 vs. -5.03 ± 0.74 mg/dL and -0.23 ± 0.01 vs. -0.22 ± 0.03 vs. -0.13 ± 0.01; p = < 0.05). FBG decreased across all groups but was not statistically significant. Conclusion: After 90 days, the combination of decaffeinated green tea and green coffee significantly reduced PPBG and HbA1C levels in patients with metabolic syndrome compared to the placebo. These findings suggest that this combination may serve as an effective adjunctive therapy for glucose management in metabolic syndrome, translating efficacious preclinical dosages to clinical application.

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Rekan penulisOrganisasiArtikel bersama
Anna Fuji RahimahUniversity of Brawijaya42
Ardian RizalUniversity of Brawijaya35
Indra PrasetyaUniversity of Brawijaya32
Budi SatrijoUniversity of Brawijaya31
Setyasih AnjarwaniUniversity of Brawijaya30
Sasmojo WiditoUniversity of Brawijaya30
Djanggan SargowoUniversity of Brawijaya28
Heny MartiniUniversity of Brawijaya27
Yoga WaranugrahaUniversity of Brawijaya14
Valerinna YogibuanaAfiliasi tidak diketahui9
Adhika Prastya WikanandaUniversity of Brawijaya8
Muhammad Rizki FadlanUniversity of Brawijaya7
Tri AstiawatiUniversity of Brawijaya6
Seprian WidasmaraUniversity of Brawijaya6
Putri Annisa KamilaUniversity of Brawijaya5
Dadang HendrawanUniversity of Brawijaya5
Anna Fuji RahimahAfiliasi tidak diketahui5
Ratna PancasariUniversity of Brawijaya5
Ayu Asri Devi AdityawatiUniversity of Brawijaya5
Oktafin Srywati PamunaUniversity of Brawijaya5
Valerinna Yogibuana Swastika PutriUniversity of Brawijaya5
Nikhen NoverikeUniversity of Brawijaya5
Fandy HazzyUniversity of Brawijaya4
Sawitri SatwikajatiUniversity of Brawijaya4
Saskia Dyah HandariUniversity of Brawijaya4
Hayla Iqda MillisaniUniversity of Brawijaya4
Fahmy RusnantaUniversity of Brawijaya4
Imelda KrisnasariUniversity of Brawijaya4
Evit RuspionoAfiliasi tidak diketahui4
Zainal FathurohimUniversity of Brawijaya4
N KaputrinUniversity of Brawijaya3
Teguh AryanugrahaUniversity of Brawijaya3
Imam Mi'raj SuprayogaUniversity of Brawijaya3
Dea Arie KurniawanUniversity of Brawijaya3
Zhafran VeliawanUniversity of Brawijaya3

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Sumber metadata: OAI-PMH (metadata jurnal) https://heartscience.ub.ac.id/index.php/heartscience/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Effect of decaffeinated green tea and green coffee combination on improving blood glucose levels in metabolic syndrome patients</dc:title>
	<dc:creator xml:lang="en">Nugroho, Ira Vori</dc:creator>
	<dc:creator xml:lang="en">Rohman, Mohammad Saifur</dc:creator>
	<dc:creator xml:lang="en">Karolina, Wella </dc:creator>
	<dc:creator xml:lang="en">Tjahjono, Cholid Tri</dc:creator>
	<dc:creator xml:lang="en">Kurnianingsih, Novi </dc:creator>
	<dc:subject xml:lang="en">Chlorogenic Acid</dc:subject>
	<dc:subject xml:lang="en">Epigallocatechin Gallate</dc:subject>
	<dc:subject xml:lang="en">Glucose Management</dc:subject>
	<dc:subject xml:lang="en">Green Coffee</dc:subject>
	<dc:subject xml:lang="en">Green Tea</dc:subject>
	<dc:subject xml:lang="en">Metabolic Syndrome</dc:subject>
	<dc:description xml:lang="en">Background: Metabolic syndrome (MS) contributes to high mortality and morbidity not only in developing countries but also in developed countries, with central obesity and insulin resistance as primary risk factors. Our previous study demonstrated that combined decaffeinated green tea and green coffee extracts more effectively improved lipid and glucose profiles in an MS rat model.
Objective: This study evaluates the efficacy of the extracts on top guideline-directed medical treatment optimal therapy in metabolic syndrome patients.
Methods: The study was a randomized controlled trial (RCT) involving 90 patients diagnosed with metabolic syndrome, ages 45-70. Participants were randomly sorted into three groups: the first group received 2x2.5 g, the second group received 1x5 g, and the third one received a placebo. Researchers measured baseline and final values for fasting blood glucose (FBG), post-meal glucose levels (PPBG), and glycated hemoglobin (HbA1C) to evaluate treatment effects.
Result: After 90 days of treatment with decaffeinated green tea and green coffee combination, both experimental groups (Groups 1 and 2) revealed significant decreases in PPBG and HbA1c compared to the control group. (-14.10 ± 2.00 vs. -28.63 ± 4.61 vs. -5.03 ± 0.74 mg/dL and -0.23 ± 0.01 vs. -0.22 ± 0.03 vs. -0.13 ± 0.01; p = &amp;lt; 0.05). FBG decreased across all groups but was not statistically significant.
Conclusion: After 90 days, the combination of decaffeinated green tea and green coffee significantly reduced PPBG and HbA1C levels in patients with metabolic syndrome compared to the placebo. These findings suggest that this combination may serve as an effective adjunctive therapy for glucose management in metabolic syndrome, translating efficacious preclinical dosages to clinical application.</dc:description>
	<dc:publisher xml:lang="en">Universitas Brawijaya</dc:publisher>
	<dc:date>2026-01-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://heartscience.ub.ac.id/index.php/heartscience/article/view/20388</dc:identifier>
	<dc:identifier>10.21776/ub.hsj.2026.007.01.12</dc:identifier>
	<dc:source xml:lang="en">Heart Science Journal; Vol. 7 No. 1 (2026): Accelerating Clinical Breakthroughs: The Journey from Molecular Discovery to Patient Care; 68-72</dc:source>
	<dc:source>2721-9984</dc:source>
	<dc:source>2721-9976</dc:source>
	<dc:source>10.21776/ub.hsj.2026.007.01</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://heartscience.ub.ac.id/index.php/heartscience/article/view/20388/560</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2026 Ira Vori Nugroho, Mohammad Saifur Rohman, Wella Karolina, Cholid Tri Tjahjono, Novi Kurnianingsih</dc:rights>
	<dc:rights xml:lang="en">http://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>