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The effect of increased uric acid levels on the severity of coronary artery stenosis based on SYNTAX score in patients with chronic coronary syndrome

Heart Science Journal · Vol. 7 No. 2 (2026) · hlm. 86–90

DOI
10.21776/ub.hsj.2026.007.02.13
ISSN
2721-9984, 2721-9976
Terbit
2026-04-26
Penerbit
Universitas Brawijaya
Bahasa
en
Lisensi
creativecommons.org/licenses/by/4.0

Abstrak

Background: Recent findings indicate that the adverse effects of uric acid (UA) on the coronary arteries contribute to the severity of atherosclerotic disease. Objective: This analysis investigates the relationship between serum uric acid concentrations and the SYNTAX score, quantifying coronary artery disease severity (CAD). Methods: A cross-sectional study took place at Saiful Anwar General Hospital from January 2022 to December 2024. A total of 1156 patients diagnosed with CAD who underwent coronary angiography were chosen for the study. Result: The analysis of uric acid levels led to the classification of participants into two distinct groups: the hyperuricemia group (n = 396) and the normouricemia group (n = 760). The analysis involved comparing the groups in terms of the occurrence of CAD and SYNTAX score while examining gender-specific quartiles of uric acid levels. The clinical baseline data underwent evaluation through suitable statistical methods, and a multivariate logistic regression analysis was conducted to pinpoint independent risk factors for CAD. Conclusion: UA showed a positive relationship with the SYNTAX score in individuals with CAD. It serves as an independent indicator for assessing the extent of coronary artery stenosis and has predictive capabilities.

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  • University of Brawijaya
  • RSUD Prof. Dr. Saiful Anwar Malang
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Rekan penulisOrganisasiArtikel bersama
Mohammad Saifur RohmanUniversity of Brawijaya17
Setyasih AnjarwaniUniversity of Brawijaya9
Cholid Tri TjahjonoUniversity of Brawijaya9
Indra PrasetyaUniversity of Brawijaya8
Djanggan SargowoUniversity of Brawijaya7
Sasmojo WiditoUniversity of Brawijaya7
Novi KurnianingsihUniversity of Brawijaya7
Anna Fuji RahimahUniversity of Brawijaya5
Muhammad Rizki FadlanUniversity of Brawijaya3
Ardian RizalUniversity of Brawijaya3
Yoga WaranugrahaUniversity of Brawijaya2
Putri Annisa KamilaUniversity of Brawijaya2
Heny MartiniUniversity of Brawijaya2
Dea Arie KurniawanUniversity of Brawijaya2
Anna Fuji RahimahAfiliasi tidak diketahui2
Harris KristantoUniversity of Brawijaya2
Valerinna Yogibuana Swastika PutriUniversity of Brawijaya2
Shalahuddin Suryo BaskoroUniversity of Brawijaya2
Muhammad Saifur RohmanAfiliasi tidak diketahui2
Merlita HerbaniUniversity of Brawijaya2
Yoseph Budi UtomoUniversity of Brawijaya1
Olivia HandayaniUniversity of Brawijaya1
Dadang HendrawanUniversity of Brawijaya1
Anita Surya SantosoUniversity of Brawijaya1
Hendrawati HendrawatiUniversity of Brawijaya1
Liemena Harold AdrianRSUD Prof. Dr. Saiful Anwar Malang1
Aditya Reza PratamaUniversity of Brawijaya1
Ayu Asri Devi AdityawatiUniversity of Brawijaya1
Imelda KrisnasariUniversity of Brawijaya1
Arief WibisonoAfiliasi tidak diketahui1
Bayu Purnomo AjiUniversity of Brawijaya1
Krishna Ari NugrahaAfiliasi tidak diketahui1
Seprian WidasmaraUniversity of Brawijaya1
Iskandar IskandarUniversity of Brawijaya1
Valerinna YogibuanaAfiliasi tidak diketahui1
Yudi Putra ApridityaUniversity of Brawijaya1
Andona Murni MaharaniAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://heartscience.ub.ac.id/index.php/heartscience/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">The effect of increased uric acid levels on the severity of coronary artery stenosis based on SYNTAX score in patients with chronic coronary syndrome</dc:title>
	<dc:creator xml:lang="en">Lestari, Defyna Dwi</dc:creator>
	<dc:creator xml:lang="en">Budi Satrijo</dc:creator>
	<dc:creator xml:lang="en">Mohamad Saifur Rohman</dc:creator>
	<dc:subject xml:lang="en">Coronary Artery Disease</dc:subject>
	<dc:subject xml:lang="en">SYNTAX Score</dc:subject>
	<dc:subject xml:lang="en">Uric Acid</dc:subject>
	<dc:subject xml:lang="en">Coronary Angiography</dc:subject>
	<dc:description xml:lang="en">



 
Background: Recent findings indicate that the adverse effects of uric acid (UA) on the coronary arteries contribute to the severity of atherosclerotic disease.
Objective: This analysis investigates the relationship between serum uric acid concentrations and the SYNTAX score, quantifying coronary artery disease severity (CAD).
Methods: A cross-sectional study took place at Saiful Anwar General Hospital from January 2022 to December 2024.  A total of 1156 patients diagnosed with CAD who underwent coronary angiography were chosen for the study.
Result: The analysis of uric acid levels led to the classification of participants into two distinct groups: the hyperuricemia group (n = 396) and the normouricemia group (n = 760).  The analysis involved comparing the groups in terms of the occurrence of CAD and SYNTAX score while examining gender-specific quartiles of uric acid levels.     The clinical baseline data underwent evaluation through suitable statistical methods, and a multivariate logistic regression analysis was conducted to pinpoint independent risk factors for CAD.
Conclusion: UA showed a positive relationship with the SYNTAX score in individuals with CAD. It serves as an independent indicator for assessing the extent of coronary artery stenosis and has predictive capabilities.
 



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	<dc:publisher xml:lang="en">Universitas Brawijaya</dc:publisher>
	<dc:date>2026-04-26</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://heartscience.ub.ac.id/index.php/heartscience/article/view/20409</dc:identifier>
	<dc:identifier>10.21776/ub.hsj.2026.007.02.13</dc:identifier>
	<dc:source xml:lang="en">Heart Science Journal; Vol. 7 No. 2 (2026): The Evolving Landscape of Heart Failure; 86-90</dc:source>
	<dc:source>2721-9984</dc:source>
	<dc:source>2721-9976</dc:source>
	<dc:source>10.21776/ub.hsj.2026.007.02</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://heartscience.ub.ac.id/index.php/heartscience/article/view/20409/584</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2026 Defyna Dwi Lestari, Budi Satrijo, Mohamad Saifur Rohman</dc:rights>
	<dc:rights xml:lang="en">http://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>