Melola Discovery

← Melola Discovery

Akses terbuka Jurnal SINTA 1

Beyond solely estrogen: Sex-based differences in platelet biology and antithrombotic response

Heart Science Journal · Vol. 7 No. 2 (2026) · hlm. 36–42

DOI
10.21776/ub.hsj.2026.007.02.6
ISSN
2721-9984, 2721-9976
Terbit
2026-04-26
Penerbit
Universitas Brawijaya
Bahasa
en
Lisensi
creativecommons.org/licenses/by/4.0

Abstrak

Despite increased awareness of sex differences in cardiovascular disease (CVD), disparities in sex-specific platelet biology and antithrombotic studies are still underexplored. Moreover, women are frequently underrepresented in clinical trials, with numerous research initiatives primarily focusing on estrogen while neglecting non-hormonal influences that contribute variations in thrombotic risk and treatment outcomes. We conducted a literature review to examine sex-related differences in platelet biology, such as elevated platelet counts and reactivity in females, along with distinct expression of receptors and signaling molecules. These variations influence responses to antiplatelet medications—including aspirin, P2Y12 inhibitors, and glycoprotein IIb/IIIa inhibitors, and dual antiplatelet therapy—leading to altered effectiveness and a heightened bleeding risk in women. This review emphasizes the importance of non-hormonal factors, such as transcriptomic and proteomic variations, and highlights the growing potential of omics and systems biology in identifying therapeutic targets specific to sex. Incorporating sex as a biological factor in preclinical and clinical research is crucial for enhancing risk assessment and treatment results.

Kata kunci

Jaringan kolaborasi para penulis

32 penulis · 160 tautan kepenulisan bersama

Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.

  • Universitas Muhammadiyah Gorontalo
  • Universitas Airlangga
  • Universitas Nurul Jadid
  • Taipei Medical University
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
  • Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel
Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Nathanael Jonathan TjiptaAfiliasi tidak diketahui2
Chaq El Chaq Zamzam MultazamAfiliasi tidak diketahui2
Melita Amalia AyubaAfiliasi tidak diketahui2
Mochamad YusufAfiliasi tidak diketahui2
Gwenny Ichsan PrabowoAfiliasi tidak diketahui2
Bayu Satria WiratamaTaipei Medical University2
Soetjipto SoetjiptoAfiliasi tidak diketahui2
Langgeng Agung WaskitoAfiliasi tidak diketahui2
Clarissa ElvarettaAfiliasi tidak diketahui2
Dian Eka Roro PalupiAfiliasi tidak diketahui2
Ema QurnianingsihAfiliasi tidak diketahui2
Lina LukitasariAfiliasi tidak diketahui2
Ira HumairahAfiliasi tidak diketahui2
Siti KhaerunnisaAfiliasi tidak diketahui2
Retno HandajaniAfiliasi tidak diketahui2
Indri SafitriAfiliasi tidak diketahui2
Fithriyah Cholifatul UmmahAfiliasi tidak diketahui2
Indah Binti Mohd AminAfiliasi tidak diketahui2
Syahrial SyahrialUniversitas Muhammadiyah Gorontalo1
Eryc PranataAfiliasi tidak diketahui1
Alfian Nur RosyidUniversitas Airlangga1
David Setyo BudiAfiliasi tidak diketahui1
Ifan Ali WafaAfiliasi tidak diketahui1
Nando Reza PratamaAfiliasi tidak diketahui1
Henry SutantoAfiliasi tidak diketahui1
Ahmad ZubaidiUniversitas Nurul Jadid1
Su RitohardoyoAfiliasi tidak diketahui1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) https://heartscience.ub.ac.id/index.php/heartscience/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Beyond solely estrogen: Sex-based differences in platelet biology and antithrombotic response</dc:title>
	<dc:creator xml:lang="en">Salma, Zaskia Nafisa</dc:creator>
	<dc:creator xml:lang="en">Susilo, Hendri</dc:creator>
	<dc:creator xml:lang="en">Wungu, Citrawati Dyah Kencono</dc:creator>
	<dc:creator xml:lang="en">Tandecxi, Gabriel</dc:creator>
	<dc:creator xml:lang="en">Nugrahani, Annisa Salsabilla Dwi</dc:creator>
	<dc:subject xml:lang="en">platelet</dc:subject>
	<dc:subject xml:lang="en">sex difference</dc:subject>
	<dc:subject xml:lang="en">antithrombotic therapy</dc:subject>
	<dc:subject xml:lang="en">cardiovascular disease</dc:subject>
	<dc:description xml:lang="en">Despite increased awareness of sex differences in cardiovascular disease (CVD), disparities in sex-specific platelet biology and antithrombotic studies are still underexplored. Moreover, women are frequently underrepresented in clinical trials, with numerous research initiatives primarily focusing on estrogen while neglecting non-hormonal influences that contribute variations in thrombotic risk and treatment outcomes.
We conducted a literature review to examine sex-related differences in platelet biology, such as elevated platelet counts and reactivity in females, along with distinct expression of receptors and signaling molecules. These variations influence responses to antiplatelet medications—including aspirin, P2Y12 inhibitors, and glycoprotein IIb/IIIa inhibitors, and dual antiplatelet therapy—leading to altered effectiveness and a heightened bleeding risk in women. This review emphasizes the importance of non-hormonal factors, such as transcriptomic and proteomic variations, and highlights the growing potential of omics and systems biology in identifying therapeutic targets specific to sex. Incorporating sex as a biological factor in preclinical and clinical research is crucial for enhancing risk assessment and treatment results.</dc:description>
	<dc:publisher xml:lang="en">Universitas Brawijaya</dc:publisher>
	<dc:date>2026-04-26</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://heartscience.ub.ac.id/index.php/heartscience/article/view/20569</dc:identifier>
	<dc:identifier>10.21776/ub.hsj.2026.007.02.6</dc:identifier>
	<dc:source xml:lang="en">Heart Science Journal; Vol. 7 No. 2 (2026): The Evolving Landscape of Heart Failure; 36-42</dc:source>
	<dc:source>2721-9984</dc:source>
	<dc:source>2721-9976</dc:source>
	<dc:source>10.21776/ub.hsj.2026.007.02</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://heartscience.ub.ac.id/index.php/heartscience/article/view/20569/577</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2026 Zaskia Nafisa Salma, Hendri Susilo, Citrawati Dyah Kencono Wungu, Gabriel Tandecxi, Annisa Salsabilla Dwi Nugrahani</dc:rights>
	<dc:rights xml:lang="en">http://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>