Melola Discovery

← Melola Discovery

Akses terbuka Jurnal SINTA 1

Antioxidant and Cytotoxic Properties of Soft Coral Nepthea sp.

ILMU KELAUTAN: Indonesian Journal of Marine Sciences · Vol. 27 No. 1 (2022) · hlm. 29–36

DOI
10.14710/ik.ijms.27.1.29-36
ISSN
2406-7598, 0853-7291
Terbit
2022-02-13
Penerbit
Marine Science Department Diponegoro University
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-sa/4.0

Abstrak

Soft coral Nepthea sp. grows in the seas of South-East Sulawesi, Indonesia. However, information on the chemical and pharmaceutical aspects of this genus is still limited. Therefore, this research aims to explore the chemical contents and biological activities of Nepthea sp. The sample was collected from the waters of Saponda Island by SCUBA diving. It was extracted by ethyl acetate and fractionated using vacuum liquid chromatography. The chemical content was analyzed by phytochemical screening, LC-MS/MS analysis, Total Phenolics Content and Total Flavonoids Contents. Antioxidant potency was evaluated by DPPH (2,2-diphenyl-1-picrylhydrazyl) radicals and ABTS (2,2’-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid). Cytotoxicity property was analyzed by MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assays. The result showed that the fractionation of Nepthea ethylacetate extracts produced six fractions (A-F). Fractions A and B contain non-polar compounds. Based on LC-MS/MS data, the non-polar compounds in Fraction A and B include achillin, atractylenolide II, buthyl isobuthyl phthalate, rengyolester, 2a-acetoxycostic acid, ocotillol acetate, petasitolone and some unidentified compounds that are C33H58O4, C15H21NO, C21H33NO, and C16H20O4. In general, the antioxidant and cytotoxic properties of all samples are in the weak category, however, when examined for each sample, the antioxidant properties of fraction B is slightly better than fraction A based on the IC50 value of DPPH and ABTS. Cytotoxicity of Fraction A is better than Fraction B against Breast Cancer cell lines MCF-7. The non-polar fraction of Nepthea sp. can be developed as raw material for the discovery of new compounds, antioxidant and anticancer agents, especially breast cancer.

Kata kunci

Jaringan kolaborasi para penulis

40 penulis · 140 tautan kepenulisan bersama · 56 lintas organisasi · menampilkan 40 yang paling banyak terhubung

Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.

  • Universitas Halu Oleo
  • Politeknik Bina Husada Kendari
  • Thammasat University
  • National Research and Innovation Agency
  • National University of Malaysia
  • Malikussaleh University
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
  • Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel
Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Sahidin SahidinUniversitas Halu Oleo13
Ratna Diyah PalupiUniversitas Halu Oleo8
. RahmadaniAfiliasi tidak diketahui8
Muhammad Hajrul MalakaUniversitas Halu Oleo8
Arfan ArfanUniversitas Halu Oleo7
Angriani FusvitaPoliteknik Bina Husada Kendari6
Nur Saadah DaudPoliteknik Bina Husada Kendari6
Muhammad Ilyas YUniversitas Halu Oleo5
Lidya Agriningsih HarunaThammasat University5
La Ode Muhammad Julian PurnamaThammasat University5
Rathapon AsasutjaritThammasat University5
Akhmad MansyurUniversitas Halu Oleo4
Musdalipah MusdalipahPoliteknik Bina Husada Kendari4
W WahyuniUniversitas Halu Oleo3
Esti BadiaPoliteknik Bina Husada Kendari3
Roslindah Daeng SiangUniversitas Halu Oleo2
Nurdiana A.Afiliasi tidak diketahui2
Asriullah JabbarUniversitas Halu Oleo2
Subhan SubhanAfiliasi tidak diketahui2
. SubhanAfiliasi tidak diketahui2
Ishak IskandarUniversitas Halu Oleo1
Andi Irwan NurUniversitas Halu Oleo1
Ari Sandy MuchtarUniversitas Halu Oleo1
Aldiansyah Hari FriatnoAfiliasi tidak diketahui1
S SahidinUniversitas Halu Oleo1
Wa Ode Nia HelmiaUniversitas Halu Oleo1
Musadar MappasombaUniversitas Halu Oleo1
Bayu WirasmantoUniversitas Halu Oleo1
Khansa Rafida TriaqilahUniversitas Halu Oleo1
Mubarak MubarakUniversitas Halu Oleo1
Faisal FaisalMalikussaleh University1
Siti HasmaUniversitas Halu Oleo1
Esna NirwanaAfiliasi tidak diketahui1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) http://ejournal.undip.ac.id/index.php/ijms/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Antioxidant and Cytotoxic Properties of Soft Coral Nepthea sp.</dc:title>
	<dc:creator>Sadarun, Baru</dc:creator>
	<dc:creator>Rahmatika, Nur Syifa</dc:creator>
	<dc:creator>Yodha, Agung Wibawa Mahatva</dc:creator>
	<dc:creator>Fristiohady, Adryan</dc:creator>
	<dc:creator>Sundowo, Andini</dc:creator>
	<dc:creator>Baharum, Syarul Nataqain</dc:creator>
	<dc:creator>Sahidin, Idin</dc:creator>
	<dc:subject xml:lang="en-US">Nepthea sp.; non-polar fraction; antioxidant; cytotoxic; South East Sulawesi</dc:subject>
	<dc:description xml:lang="en-US">Soft coral Nepthea sp. grows in the seas of South-East Sulawesi, Indonesia. However, information on the chemical and pharmaceutical aspects of this genus is still limited. Therefore, this research aims to explore the chemical contents and biological activities of Nepthea sp. The sample was collected from the waters of Saponda Island by SCUBA diving. It was extracted by ethyl acetate and fractionated using vacuum liquid chromatography. The chemical content was analyzed by phytochemical screening, LC-MS/MS analysis, Total Phenolics Content and Total Flavonoids Contents. Antioxidant potency was evaluated by DPPH (2,2-diphenyl-1-picrylhydrazyl) radicals and ABTS (2,2’-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid). Cytotoxicity property was analyzed by MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assays. The result showed that the fractionation of Nepthea ethylacetate extracts produced six fractions (A-F). Fractions A and B contain non-polar compounds. Based on LC-MS/MS data, the non-polar compounds in Fraction A and B include achillin, atractylenolide II, buthyl isobuthyl phthalate, rengyolester, 2a-acetoxycostic acid, ocotillol acetate, petasitolone and some unidentified compounds that are C33H58O4, C15H21NO, C21H33NO, and C16H20O4. In general, the antioxidant and cytotoxic properties of all samples are in the weak category, however, when examined for each sample, the antioxidant properties of fraction B is slightly better than fraction A based on the IC50 value of DPPH and ABTS. Cytotoxicity of Fraction A is better than Fraction B against Breast Cancer cell lines MCF-7. The non-polar fraction of Nepthea sp. can be developed as raw material for the discovery of new compounds, antioxidant and anticancer agents, especially breast cancer.</dc:description>
	<dc:publisher xml:lang="en-US">Marine Science Department Diponegoro University</dc:publisher>
	<dc:date>2022-02-13</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US"></dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ejournal.undip.ac.id/index.php/ijms/article/view/43254</dc:identifier>
	<dc:identifier>10.14710/ik.ijms.27.1.29-36</dc:identifier>
	<dc:source xml:lang="en-US">ILMU KELAUTAN: Indonesian Journal of Marine Sciences; Vol 27, No 1 (2022): Ilmu Kelautan; 29-36</dc:source>
	<dc:source>2406-7598</dc:source>
	<dc:source>0853-7291</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ejournal.undip.ac.id/index.php/ijms/article/view/43254/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2022 ILMU KELAUTAN: Indonesian Journal of Marine Sciences</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by-sa/4.0</dc:rights>
</oai_dc:dc>