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Steroidal and Potential Anti-inflammatory Properties of Carteriospongia sp from the Southeast Sulawesi Sea Coast

ILMU KELAUTAN: Indonesian Journal of Marine Sciences · Vol. 30 No. 3 (2025) · hlm. 453–464

DOI
10.14710/ik.ijms.30.3.453-464
ISSN
2406-7598, 0853-7291
Terbit
2025-09-10
Penerbit
Marine Science Department Diponegoro University
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-sa/4.0

Abstrak

Marine sponges are an abundant yet underutilized resource in Southeast Sulawesi, Indonesia, despite their ecological roles and pharmacological potential. Steroidal metabolites are dominant in many sponge species and have been widely recognized for their strong anti-inflammatory activity. However, the chemical composition and biological potential of Carteriospongia sp from Indonesian waters remain unexplored. Carteriospongia sp was extracted using the Soxhlet method, and the chemical profile was analyzed by Gas Chromatography–Mass Spectrophotometry (GC-MS). Anti-inflammatory activity was evaluated in vitro using the Bovine Serum Albumin (BSA) protein denaturation assay, with methylprednisolone as the positive control. Molecular docking studies were performed to assess the interactions between steroidal compounds and BSA protein. GC-MS analysis identified eight steroidal compounds such as 2-methylenecholestan-3-ol (S1), stigmasterol (S2), 4,4-dimethyl-cholesta-8,24-dien-3-ol (S3), 8,14-seco-3,19-epoxyandrostane-8,14-dione, 17-acetoxy-3ß-methoxy-4,4-dimethyl (S4), cholic acid ethyl ester (S5), (3ß,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-3,24,25-triol (S6), stigmastan-3-en-6-ol (S7), ß-sitosterol (S8). The extract demonstrated concentration-dependent inhibition of protein denaturation, achieving 84.81% inhibition at 128 mg.L-1. The IC50 value was 3.71 mg.L-1, comparable to methylprednisolone (IC50 4.45 mg.L-1). Molecular docking revealed that compound S1 and S4 exhibited lower binding energies than other steroids, suggesting stronger stabilization of BSA protein. The findings demonstrate that Carteriospongia sp extract possesses significant anti-inflammatory potential, comparable to methylprednisolone. This study provides novel insights into the bioactive potential of Indonesian marine sponges and emphasizes the importance of further pharmacological and molecular studies to develop sponge-derived steroidal compounds as alternative or complementary anti-inflammatory therapeutics.

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  • Universitas Halu Oleo
  • Politeknik Bina Husada Kendari
  • Thammasat University
  • National Research and Innovation Agency
  • National University of Malaysia
  • Institut Agama Islam Negeri Kendari
  • Afiliasi tidak diketahui
  • Organisasi berbeda
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  • Afiliasi tidak diketahui
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Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Andini SundowoNational Research and Innovation Agency11
Idin SahidinUniversitas Halu Oleo10
Muhammad Hajrul MalakaUniversitas Halu Oleo10
Ratna Diyah PalupiUniversitas Halu Oleo8
. RahmadaniAfiliasi tidak diketahui8
Esti BadiaPoliteknik Bina Husada Kendari7
Syarul Nataqain BaharumNational University of Malaysia6
Lidya Agriningsih HarunaThammasat University5
La Ode Muhammad Julian PurnamaThammasat University5
Rathapon AsasutjaritThammasat University5
Akhmad MansyurUniversitas Halu Oleo4
Sunandar IhsanUniversitas Halu Oleo2
Roslindah Daeng SiangUniversitas Halu Oleo2
Nurdiana A.Afiliasi tidak diketahui2
Subhan SubhanAfiliasi tidak diketahui2
. SubhanAfiliasi tidak diketahui2
Wa Ode Sitti ZubaydahUniversitas Halu Oleo1
Yamin YaminUniversitas Halu Oleo1
Muhammad Handoyo SahumenaUniversitas Halu Oleo1
Ishak IskandarUniversitas Halu Oleo1
Andi Irwan NurUniversitas Halu Oleo1
Ari Sandy MuchtarUniversitas Halu Oleo1
Aldiansyah Hari FriatnoAfiliasi tidak diketahui1
W WahyuniUniversitas Halu Oleo1
S SahidinUniversitas Halu Oleo1
Sabarudin SabarudinUniversitas Halu Oleo1
Waode Indri Sasmita HasmiUniversitas Halu Oleo1
Irvan AnwarUniversitas Halu Oleo1
Nurul HukmahUniversitas Halu Oleo1
Susanti SusantiInstitut Agama Islam Negeri Kendari1
Bobi AnggriawanAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) http://ejournal.undip.ac.id/index.php/ijms/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Steroidal and Potential Anti-inflammatory Properties of Carteriospongia sp from the Southeast Sulawesi Sea Coast</dc:title>
	<dc:creator>Daud, Nur Saadah</dc:creator>
	<dc:creator>Yodha, Agung Wibawa Mahatva</dc:creator>
	<dc:creator>Musdalipah, Musdalipah</dc:creator>
	<dc:creator>Fusvita, Angriani</dc:creator>
	<dc:creator>Firdayanti, Firdayanti</dc:creator>
	<dc:creator>Sahidin, Sahidin</dc:creator>
	<dc:creator>Arfan, Arfan</dc:creator>
	<dc:creator>Fristiohady, Adryan</dc:creator>
	<dc:creator>Sadarun, Baru</dc:creator>
	<dc:subject xml:lang="en-US">Carteriospongia sp; steroid; protein denaturation; anti-inflammatory; Southeast Sulawesi</dc:subject>
	<dc:description xml:lang="en-US">Marine sponges are an abundant yet underutilized resource in Southeast Sulawesi, Indonesia, despite their ecological roles and pharmacological potential. Steroidal metabolites are dominant in many sponge species and have been widely recognized for their strong anti-inflammatory activity. However, the chemical composition and biological potential of Carteriospongia sp from Indonesian waters remain unexplored. Carteriospongia sp was extracted using the Soxhlet method, and the chemical profile was analyzed by Gas Chromatography–Mass Spectrophotometry (GC-MS). Anti-inflammatory activity was evaluated in vitro using the Bovine Serum Albumin (BSA) protein denaturation assay, with methylprednisolone as the positive control. Molecular docking studies were performed to assess the interactions between steroidal compounds and BSA protein. GC-MS analysis identified eight steroidal compounds such as 2-methylenecholestan-3-ol (S1), stigmasterol (S2), 4,4-dimethyl-cholesta-8,24-dien-3-ol (S3), 8,14-seco-3,19-epoxyandrostane-8,14-dione, 17-acetoxy-3ß-methoxy-4,4-dimethyl (S4), cholic acid ethyl ester (S5),  (3ß,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-3,24,25-triol (S6), stigmastan-3-en-6-ol (S7), ß-sitosterol (S8). The extract demonstrated concentration-dependent inhibition of protein denaturation, achieving 84.81% inhibition at 128 mg.L-1. The IC50 value was 3.71 mg.L-1, comparable to methylprednisolone (IC50 4.45 mg.L-1). Molecular docking revealed that compound S1 and S4 exhibited lower binding energies than other steroids, suggesting stronger stabilization of BSA protein. The findings demonstrate that Carteriospongia sp extract possesses significant anti-inflammatory potential, comparable to methylprednisolone. This study provides novel insights into the bioactive potential of Indonesian marine sponges and emphasizes the importance of further pharmacological and molecular studies to develop sponge-derived steroidal compounds as alternative or complementary anti-inflammatory therapeutics.</dc:description>
	<dc:publisher xml:lang="en-US">Marine Science Department Diponegoro University</dc:publisher>
	<dc:date>2025-09-10</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US"></dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ejournal.undip.ac.id/index.php/ijms/article/view/65519</dc:identifier>
	<dc:identifier>10.14710/ik.ijms.30.3.453-464</dc:identifier>
	<dc:source xml:lang="en-US">ILMU KELAUTAN: Indonesian Journal of Marine Sciences; Vol 30, No 3 (2025): Ilmu Kelautan; 453-464</dc:source>
	<dc:source>2406-7598</dc:source>
	<dc:source>0853-7291</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ejournal.undip.ac.id/index.php/ijms/article/view/65519/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2025 ILMU KELAUTAN: Indonesian Journal of Marine Sciences</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by-sa/4.0</dc:rights>
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