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In vivo Anti-arthritic Activity of Soft Coral Lobophytum sp. From Southeast Sulawesi in Freund’s Complete Adjuvant Induced Arthritis

ILMU KELAUTAN: Indonesian Journal of Marine Sciences · Vol. 29 No. 3 (2024) · hlm. 385–392

DOI
10.14710/ik.ijms.29.3.385-392
ISSN
2406-7598, 0853-7291
Terbit
2024-09-05
Penerbit
Marine Science Department Diponegoro University
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-sa/4.0

Abstrak

Rheumatoid arthritis (RA) is a systemic, progressive, chronic autoimmune inflammatory disease that affects tissues, organs, and damages synovial joints. The RA can be treated with DMARD (disease modifying anti rheumatic drugs), such as methotrexate. However, the use of this drug long-term can cause side effects. Soft coral Lobophytum sp. has secondary metabolite compounds such as flavonoids, alkaloids, and terpenoids which has an anti-inflammatory activity, which beneficial for anti-rheumatoid arthritis agent. This study aims to determine the potential of anti RA in Lobophytum sp. using in vitro and in vivo. The anti-inflammatory assay for anti RA in vitro was performed by stabilization of human red blood cell (HRBC) membrane. In addition, anti RA was performed in arthritis model mice by induction of complete Freund’s adjuvant (CFA) by administering LEA once daily orally for 15 days. It was found that the ethyl acetate of Lobophytum sp. (LEA) reduced the haemolysis and increased the stability of HRBC membrane. Furthermore, LEA also showed anti RA by decreasing the edema in mouse paw at dose of 50 mg.kg-1 BW (LEA50), 100 mg.kg-1 BW (LEA100), and 200 mg.kg-1 BW (LEA200), respectively with 2.5 mg.kg-1 BW of methotrexate as positive control (C+) with P 0.05). In conclusion, our research has shown that LEA has anti-inflammatory for treatment of rheumatoid arthritis from in vitro and in vivo studies.

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  • Universitas Halu Oleo
  • Hasanuddin University
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Rekan penulisOrganisasiArtikel bersama
Sahidin SahidinAfiliasi tidak diketahui19
Baru SadarunUniversitas Halu Oleo12
Andini SundowoAfiliasi tidak diketahui7
Musdalipah MusdalipahAfiliasi tidak diketahui6
Nur Saadah DaudAfiliasi tidak diketahui6
Angriani FusvitaAfiliasi tidak diketahui5
Rini HamsidiAfiliasi tidak diketahui5
Syarul Nataqain BaharumAfiliasi tidak diketahui5
Arfan ArfanUniversitas Halu Oleo4
Vica AspadiahAfiliasi tidak diketahui3
Rina AndrianiAfiliasi tidak diketahui3
Esti BadiaAfiliasi tidak diketahui3
Muhammad Ilyas YUniversitas Halu Oleo2
W WahyuniUniversitas Halu Oleo2
Asriullah JabbarUniversitas Halu Oleo2
Indra Saputra LiamboAfiliasi tidak diketahui2
Muhammad AzharAfiliasi tidak diketahui2
Wahyuni WahyuniHasanuddin University2
Sunandar IhsanUniversitas Halu Oleo1
Elfira HaringiAfiliasi tidak diketahui1
Wa Ode Nia HelmiaUniversitas Halu Oleo1
Musadar MappasombaUniversitas Halu Oleo1
Muhammad Hajrul MalakaUniversitas Halu Oleo1
Bayu WirasmantoUniversitas Halu Oleo1
Khansa Rafida TriaqilahUniversitas Halu Oleo1
Mubarak MubarakUniversitas Halu Oleo1
Asrul SaniUniversitas Halu Oleo1
Muzuni MuzuniAfiliasi tidak diketahui1
Mentarry BafadalAfiliasi tidak diketahui1
Rizky Barkah RamadhaniAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) http://ejournal.undip.ac.id/index.php/ijms/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">In vivo Anti-arthritic Activity of Soft Coral Lobophytum sp. From Southeast Sulawesi in Freund’s Complete Adjuvant Induced Arthritis</dc:title>
	<dc:creator>Fristiohady, Adryan</dc:creator>
	<dc:creator>Nurpajriani, Nurpajriani</dc:creator>
	<dc:creator>Malaka, Muhammad Hajrul</dc:creator>
	<dc:creator>Ilyas Y, Muhammad</dc:creator>
	<dc:creator>Pascayantri, Asniar</dc:creator>
	<dc:creator>Haruna, Lidya Agriningsih</dc:creator>
	<dc:creator>Purnama, La Ode Muh. Julian</dc:creator>
	<dc:creator>Asasutjarit, Rathapon</dc:creator>
	<dc:creator>Sahidin, Idin</dc:creator>
	<dc:creator>Yodha, Agung Wibawa Mahatva</dc:creator>
	<dc:subject xml:lang="en-US">Rheumatoid arthritis; Lobophytum sp.; rheumatoid factor; HRBC</dc:subject>
	<dc:description xml:lang="en-US">Rheumatoid arthritis (RA) is a systemic, progressive, chronic autoimmune inflammatory disease that affects tissues, organs, and damages synovial joints. The RA can be treated with DMARD (disease modifying anti rheumatic drugs), such as methotrexate. However, the use of this drug long-term can cause side effects. Soft coral Lobophytum sp. has secondary metabolite compounds such as flavonoids, alkaloids, and terpenoids which has an anti-inflammatory activity, which beneficial for anti-rheumatoid arthritis agent. This study aims to determine the potential of anti RA in Lobophytum sp. using in vitro and in vivo. The anti-inflammatory assay for anti RA in vitro was performed by stabilization of human red blood cell (HRBC) membrane. In addition, anti RA was performed in arthritis model mice by induction of complete Freund’s adjuvant (CFA) by administering LEA once daily orally for 15 days. It was found that the ethyl acetate of Lobophytum sp. (LEA) reduced the haemolysis and increased the stability of HRBC membrane. Furthermore, LEA also showed anti RA by decreasing the edema in mouse paw at dose of 50 mg.kg-1 BW (LEA50), 100 mg.kg-1 BW (LEA100), and 200 mg.kg-1 BW (LEA200), respectively with 2.5 mg.kg-1 BW of methotrexate as positive control (C+) with P&lt;0.05. Moreover, LEA200 demonstrated highest efficacy and showed no significant different with C+ (P&gt;0.05). In conclusion, our research has shown that LEA has anti-inflammatory for treatment of rheumatoid arthritis from in vitro and in vivo studies. </dc:description>
	<dc:publisher xml:lang="en-US">Marine Science Department Diponegoro University</dc:publisher>
	<dc:date>2024-09-05</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US"></dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ejournal.undip.ac.id/index.php/ijms/article/view/63361</dc:identifier>
	<dc:identifier>10.14710/ik.ijms.29.3.385-392</dc:identifier>
	<dc:source xml:lang="en-US">ILMU KELAUTAN: Indonesian Journal of Marine Sciences; Vol 29, No 3 (2024): Ilmu Kelautan; 385-392</dc:source>
	<dc:source>2406-7598</dc:source>
	<dc:source>0853-7291</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ejournal.undip.ac.id/index.php/ijms/article/view/63361/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2024 ILMU KELAUTAN: Indonesian Journal of Marine Sciences</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by-sa/4.0</dc:rights>
</oai_dc:dc>