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Apolipoprotein E as Risk Factor for Coronary Heart Disease

Indonesian Journal of Biotechnology · Vol. 18 No. 1 (2013) · hlm. 42–51

DOI
10.22146/ijbiotech.7867
ISSN
2089-2241, 0853-8654
Terbit
2013-06-09
Penerbit
Universitas Gadjah Mada
Bahasa
eng

Abstrak

Allelic variation of apolipoprotein E (apo E) has been shown to infl uence the concentrations of total cholesterol and low density lipoprotein cholesterol (LDL-C) and considered to play a role as one of risk factors for coronary heart disease (CHD). The aim of this study was to examine the relationship between Apo E polymorphism and the risk of CHD. Blood samples were collected from 33 CHD patients in Dr. Sardjito Hospital Yogyakarta, and 38 apparently healthy control individuals in a cross sectional study. The common allelic variants of ApoE were screened employing polymerase chain reaction and restriction fragment length polymorphism. The results obtained were analyzed by t-test and signifi cantly different if p <0.05 and risk factor was calculated by odd ratio. Frequency of ApoE ε2, ε2 and ε4 alleles in CHD patients were 12.1%, 69.7% and 18.2% while in controls were 18.4%, 72.4% and 9.2% respectively. Dyslipidemia condition was a strongrisk factor for CHD. By controlling lipid profi le and applying multifactorial statistic analysis, it was shown that ε4 gene carrier was the risk factor for CHD, but not in triglyceride level, whereas ε2 carrier gene was not the risk factor for CHD. Dislipidemia was the risk factor for CHD and ApoE ε4 gene carrier was the risk factor for CHD. Key words: apolipoprotein E, ApoE ε4 gene carrier, coronary heart disease, dyslipidemia.

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  • Universitas Gadjah Mada
  • National Nuclear Energy Agency of Indonesia
  • Universitas Kristen Immanuel
  • Yarsi University
  • Hokkaido University
  • Rumah Sakit Umum Pusat Dr. Sardjito
  • Sanata Dharma University
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Rekan penulisOrganisasiArtikel bersama
S SunartiUniversitas Gadjah Mada2
H. DateHokkaido University2
Yanti LusiyantiNational Nuclear Energy Agency of Indonesia2
Tur RahardjoNational Nuclear Energy Agency of Indonesia2
Nastiti RahajengNational Nuclear Energy Agency of Indonesia2
Harry Nugroho Eko SurniyantoroNational Nuclear Energy Agency of Indonesia2
Widya AsmaraUniversitas Gadjah Mada1
Marsetyawan H. N. E. SoesatyoUniversitas Gadjah Mada1
Al Supartinah SantosoUniversitas Gadjah Mada1
Regina TC. TandelilinUniversitas Gadjah Mada1
Agustina Welhelmina DjumaUniversitas Gadjah Mada1
Chusnul HidayatUniversitas Gadjah Mada1
Indro PrastowoUniversitas Gadjah Mada1
Djaswadi DasukiUniversitas Gadjah Mada1
Totok UtoroUniversitas Gadjah Mada1
Pinda HutajuluAfiliasi tidak diketahui1
Indwiani AstutiUniversitas Gadjah Mada1
Waode Astria SahraniUniversitas Gadjah Mada1
Wasilah RochmahUniversitas Gadjah Mada1
Nyoman KertiaRumah Sakit Umum Pusat Dr. Sardjito1
M. MarsetyawanUniversitas Gadjah Mada1
Putri Widelia WelkrianaUniversitas Gadjah Mada1
Dwi Aris Agung NugrahaningsihUniversitas Gadjah Mada1
Sarah Puspita AtmajaUniversitas Kristen Immanuel1
Ellsya Angeline RawarUniversitas Kristen Immanuel1
Ani KristiyaniUniversitas Kristen Immanuel1
Christine PatramurtiSanata Dharma University1

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Sumber metadata: OAI-PMH (metadata jurnal) https://jurnal.ugm.ac.id/ijbiotech/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Apolipoprotein E as Risk Factor for Coronary Heart Disease</dc:title>
	<dc:creator>Hastuti, Pramudji</dc:creator>
	<dc:creator>Sofro, Abdul Salam M.</dc:creator>
	<dc:creator>Asdie, Ahmad Husain</dc:creator>
	<dc:creator>Sadewa, Ahmad Hamim</dc:creator>
	<dc:subject xml:lang="en-US">apolipoprotein E; ApoE ε4 gene carrier; Coronary Heart Disease; Dyslipidemia</dc:subject>
	<dc:description xml:lang="en-US">Allelic variation of apolipoprotein E (apo E) has been shown to infl uence the concentrations of total cholesterol and low density lipoprotein cholesterol (LDL-C) and considered to play a role as one of risk factors for coronary heart disease (CHD). The aim of this study was to examine the relationship between Apo E polymorphism and the risk of CHD. Blood samples were collected from 33 CHD patients in Dr. Sardjito Hospital Yogyakarta, and 38 apparently healthy control individuals in a cross sectional study. The common allelic variants of ApoE were screened employing polymerase chain reaction and restriction fragment length polymorphism. The results obtained were analyzed by t-test and signifi cantly different if p &lt;0.05 and risk factor was calculated by odd ratio. Frequency of ApoE ε2, ε2 and ε4 alleles in CHD patients were 12.1%, 69.7% and 18.2% while in controls were 18.4%, 72.4% and 9.2% respectively. Dyslipidemia condition was a strongrisk factor for CHD. By controlling lipid profi le and applying multifactorial statistic analysis, it was shown that ε4 gene carrier was the risk factor for CHD, but not in triglyceride level, whereas ε2 carrier gene was not the risk factor for CHD. Dislipidemia was the risk factor for CHD and ApoE ε4 gene carrier was the risk factor for CHD. Key words: apolipoprotein E, ApoE ε4 gene carrier, coronary heart disease, dyslipidemia.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Gadjah Mada</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2013-06-09</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Original Research Articles</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.ugm.ac.id/ijbiotech/article/view/7867</dc:identifier>
	<dc:identifier>10.22146/ijbiotech.7867</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Biotechnology; Vol 18, No 1 (2013); 42-51</dc:source>
	<dc:source>2089-2241</dc:source>
	<dc:source>0853-8654</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/view/7867/6108</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2015 Indonesian Journal of Biotechnology</dc:rights>
</oai_dc:dc>