Melola Discovery

← Melola Discovery

Akses terbuka Jurnal SINTA 1

Polymorphism of Transcription Factor 7-Like 2 Gene and HOMA-β Level of Individuals With and Without Type 2 Diabetes Mellitus Family History

Indonesian Journal of Biotechnology · Vol. 19 No. 2 (2014) · hlm. 176–183

DOI
10.22146/ijbiotech.9312
ISSN
2089-2241, 0853-8654
Terbit
2014-12-08
Penerbit
Universitas Gadjah Mada
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-sa/4.0

Abstrak

Family history has considered as a risk factor of type 2 diabetes. Transcription factor-7 like 2 (TCF7L2) hasrole to regulates insulin secretion and blood glucose homeostasis. The aim of current study was to determine thers7903146 polymorphism of TCF7L2 gene and homeostatic model assessment-β (HOMA-β) level on individual withand without type 2 Diabetes Mellitus (DM) family history. This work is a case-control study. Thirty six subjectswith type 2 DM family history and 36 subjects without type 2 DM family history were recruited. HOMA-βmeasure to analyze the insulin secretion. Polymorphisms of TCF7L2 gene was analyzed by using PCR-RFLPmethod. Statistical analysis was performed by using T-test, Mann-Whitney and Chi-square with signifi cancelevel 0.05. The frequency of the T allele of the cases were 4.2% and the controls were 2.8% (p=0.500). The oddratio was 0.649 (CI;95%:0.106-4.055). The HOMA-β levels of the cases were signifi cant low (132.56±62.48)compared with the controls (266.09±1.68) with p=0.000. The subjects with type 2 DM family history have asimilar frequency of having T alleles and CT/TT genotypes. The subjects with type 2 DM family history hassignifi cantly lower HOMA-β levels than subject without DM family history.

Kata kunci

Jaringan kolaborasi para penulis

24 penulis · 59 tautan kepenulisan bersama · 30 lintas organisasi

Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.

  • Universitas Gadjah Mada
  • National Nuclear Energy Agency of Indonesia
  • Universitas Kristen Immanuel
  • Yarsi University
  • Hokkaido University
  • Diponegoro University
  • Sanata Dharma University
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
  • Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel
Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Pramudji HastutiUniversitas Gadjah Mada3
Abdul Salam M. SofroYarsi University2
Ahmad Husain AsdieUniversitas Gadjah Mada2
H. DateHokkaido University1
Yanti LusiyantiNational Nuclear Energy Agency of Indonesia1
Tur RahardjoNational Nuclear Energy Agency of Indonesia1
Nastiti RahajengNational Nuclear Energy Agency of Indonesia1
Harry Nugroho Eko SurniyantoroNational Nuclear Energy Agency of Indonesia1
Munakhir MudjosemediUniversitas Gadjah Mada1
Rurie Ratna ShantiningsihUniversitas Gadjah Mada1
Suwaldi SuwaldiUniversitas Gadjah Mada1
Djaswadi DasukiUniversitas Gadjah Mada1
Totok UtoroUniversitas Gadjah Mada1
Pinda HutajuluAfiliasi tidak diketahui1
Yuliani SetyaningsihDiponegoro University1
Adi Heru HusodoUniversitas Gadjah Mada1
Dwi Aris Agung NugrahaningsihUniversitas Gadjah Mada1
Sarah Puspita AtmajaUniversitas Kristen Immanuel1
Ellsya Angeline RawarUniversitas Kristen Immanuel1
Ani KristiyaniUniversitas Kristen Immanuel1
Christine PatramurtiSanata Dharma University1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) https://jurnal.ugm.ac.id/ijbiotech/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Polymorphism of Transcription Factor 7-Like 2 Gene and HOMA-β Level of Individuals With and Without Type 2 Diabetes Mellitus Family History</dc:title>
	<dc:creator>Sahrani, Waode Astria</dc:creator>
	<dc:creator>Astuti, Indwiani</dc:creator>
	<dc:creator>Sadewa, Ahmad Hamim</dc:creator>
	<dc:subject xml:lang="en-US">Type 2 DM family history, TCF7L2 gene, rs7903146 polymorphism, HOMA-β</dc:subject>
	<dc:description xml:lang="en-US">Family history has considered as a risk factor of type 2 diabetes. Transcription factor-7 like 2 (TCF7L2) hasrole to regulates insulin secretion and blood glucose homeostasis. The aim of current study was to determine thers7903146 polymorphism of TCF7L2 gene and homeostatic model assessment-β (HOMA-β) level on individual withand without type 2 Diabetes Mellitus (DM) family history. This work is a case-control study. Thirty six subjectswith type 2 DM family history and 36 subjects without type 2 DM family history were recruited. HOMA-βmeasure to analyze the insulin secretion. Polymorphisms of TCF7L2 gene was analyzed by using PCR-RFLPmethod. Statistical analysis was performed by using T-test, Mann-Whitney and Chi-square with signifi cancelevel 0.05. The frequency of the T allele of the cases were 4.2% and the controls were 2.8% (p=0.500). The oddratio was 0.649 (CI;95%:0.106-4.055). The HOMA-β levels of the cases were signifi cant low (132.56±62.48)compared with the controls (266.09±1.68) with p=0.000. The subjects with type 2 DM family history have asimilar frequency of having T alleles and CT/TT genotypes. The subjects with type 2 DM family history hassignifi cantly lower HOMA-β levels than subject without DM family history.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Gadjah Mada</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2014-12-08</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Original Research Articles</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.ugm.ac.id/ijbiotech/article/view/9312</dc:identifier>
	<dc:identifier>10.22146/ijbiotech.9312</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Biotechnology; Vol 19, No 2 (2014); 176-183</dc:source>
	<dc:source>2089-2241</dc:source>
	<dc:source>0853-8654</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/view/9312/6904</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2016 Waode Astria Sahrani, Indwiani Astuti, Ahmad Hamim Sadewa</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-sa/4.0</dc:rights>
</oai_dc:dc>