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Anti-metastatic effect of curcumin analog pentagamaboronon-0-fructose (PGB-0-F) against 4T1 breast cancer cells

Indonesian Journal of Biotechnology · Vol. 23 No. 2 (2018) · hlm. 109–113

DOI
10.22146/ijbiotech.36431
ISSN
2089-2241, 0853-8654
Terbit
2018-12-24
Penerbit
Universitas Gadjah Mada
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-sa/4.0

Abstrak

Development of a chemotherapeutic agent and boron carrying pharmaceutical based on triple-negative breast cancer is important due to its metastatic progression. Metastases are often more dangerous than the primary tumor and they are responsible for 90% of all cancer deaths. The purpose of this study was to explore the anti-metastatic activities of the PGB-0 complex with fructose (PGB-0-F) against 4T1 breast cancer cells. A scratch wound healing assay was carried out to determine the migration inhibition ability of PGB-0-F, while MMP-9 expression was analysed using gelatin zymography. The testing of anti-migration activity showed that PGB-0-F inhibited in 4T1 cells, whereas the gelatin zymography assay revealed a suppression of MMP-9 expression. PGB-0-F inhibited closure on 4T1 metastatic breast cancer cells line compared with the control. PGB-0-F decreased the MMP-9 expression level compared with the control. Based on these results, PGB-0-F has the potential to be developed as a chemotherapeutic agent, and especially as an anti-metastatic agent.

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Adam HermawanAfiliasi tidak diketahui23
Muthi’ IkawatiAfiliasi tidak diketahui8
Sri HandayaniUniversity of Brawijaya7
Annisa NovarinaAfiliasi tidak diketahui6
Sari HaryantiAfiliasi tidak diketahui5
Dhania NovitasariAfiliasi tidak diketahui5
Retno MurwantiAfiliasi tidak diketahui5
Dyaningtyas Dewi Pamungkas PutriAfiliasi tidak diketahui5
Larasati LarasatiIPB University5
Lailatul QodriaAfiliasi tidak diketahui4
Desty Restia RahmawatiAfiliasi tidak diketahui4
Hilyatul FadliyahAfiliasi tidak diketahui4
Indri KusharyantiAfiliasi tidak diketahui4
Nindya Budiana PutriAfiliasi tidak diketahui4
Raisatun Nisa SugiyantoAfiliasi tidak diketahui4
Anindyajati AnindyajatiAfiliasi tidak diketahui3
Sendy JunediAfiliasi tidak diketahui3
Gergorius Gena MaranAfiliasi tidak diketahui3
Faaza Aulia RahmanAfiliasi tidak diketahui3
Aulia Nur SeptianiAfiliasi tidak diketahui3
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Laeli MuntafiahAfiliasi tidak diketahui3
Bani Adlina ShabrinaAfiliasi tidak diketahui3
Rumiyati RumiyatiAfiliasi tidak diketahui3
Yuni Fajar EstiAfiliasi tidak diketahui3
Masashi KawaichiAfiliasi tidak diketahui2
Nunuk Aries NurulitaAfiliasi tidak diketahui2
Suwijiyo PramonoAfiliasi tidak diketahui2
Laili Nailul MunaAfiliasi tidak diketahui2
Asri Mega PutriAfiliasi tidak diketahui2
Yonika Arum LarasatiAfiliasi tidak diketahui2
Argandita MeiftasariAfiliasi tidak diketahui2
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Fatiha Citra EffendiAfiliasi tidak diketahui2
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Sumber metadata: OAI-PMH (metadata jurnal) https://jurnal.ugm.ac.id/ijbiotech/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Anti-metastatic effect of curcumin analog pentagamaboronon-0-fructose (PGB-0-F) against 4T1 breast cancer cells</dc:title>
	<dc:creator>Ertanto, Yogi</dc:creator>
	<dc:creator>Utomo, Rohmad Yudi</dc:creator>
	<dc:creator>Jenie, Riris Istighfari</dc:creator>
	<dc:creator>Susidarti, Ratna Asmah</dc:creator>
	<dc:creator>Meiyanto, Edy</dc:creator>
	<dc:subject xml:lang="en-US">curcumin analogue, PGB-0-F, 4T1 Cells, migration, MMP-9</dc:subject>
	<dc:description xml:lang="en-US">Development of a chemotherapeutic agent and boron carrying pharmaceutical based on triple-negative breast cancer is important due to its metastatic progression. Metastases are often more dangerous than the primary tumor and they are responsible for 90% of all cancer deaths. The purpose of this study was to explore the anti-metastatic activities of the PGB-0 complex with fructose (PGB-0-F) against 4T1 breast cancer cells. A scratch wound healing assay was carried out to determine the migration inhibition ability of PGB-0-F, while MMP-9 expression was analysed using gelatin zymography. The testing of anti-migration activity showed that PGB-0-F inhibited in 4T1 cells, whereas the gelatin zymography assay revealed a suppression of MMP-9 expression. PGB-0-F inhibited closure on 4T1 metastatic breast cancer cells line compared with the control. PGB-0-F decreased the MMP-9 expression level compared with the control. Based on these results, PGB-0-F has the potential to be developed as a chemotherapeutic agent, and especially as an anti-metastatic agent.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Gadjah Mada</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2018-12-24</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Original Research Articles</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.ugm.ac.id/ijbiotech/article/view/36431</dc:identifier>
	<dc:identifier>10.22146/ijbiotech.36431</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Biotechnology; Vol 23, No 2 (2018); 109-113</dc:source>
	<dc:source>2089-2241</dc:source>
	<dc:source>0853-8654</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/view/36431/23820</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/36431/6561</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/36431/6562</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/36431/6563</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/36431/6605</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2018 The Author(s)</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-sa/4.0</dc:rights>
</oai_dc:dc>