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Evaluation of potential gene expression as early markers of insulin resistance and non-alcoholic fatty liver disease in the Indonesian population

Indonesian Journal of Biotechnology · Vol. 23 No. 2 (2018) · hlm. 84–90

DOI
10.22146/ijbiotech.36975
ISSN
2089-2241, 0853-8654
Terbit
2018-12-24
Penerbit
Universitas Gadjah Mada
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-sa/4.0

Abstrak

Early detection of insulin resistance (IR) or non-alcoholic fatty liver disease (NAFLD) is crucial to preventing future risks of developing chronic diseases. The Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), Liver Fat Score (LFS), and Fatty Liver Index (FLI) are generally employed to measure severity stages of IR and NAFLD. The study of gene expressions could explain the molecular mechanisms that occur early on in IR and NAFLD; thus providing potential early markers for both diseases. This study was conducted to evaluate the gene expressions that could potentially be early markers of IR and NAFLD. All participants (n = 21) had normal blood glucose and were categorized as without hepatosteatosis (n = 10), at higher risk of hepatosteatosis (n = 6), and hepatosteatosis (n = 5). Gene expression analysis was performed using the 2-∆∆CT relative quantification method. There were significant differences in galnt2 (p < 0.002) and sirt1 (p < 0.010) expression between the first and the third tertiles of HOMA-IR; and in ptpn1 (p < 0.012) expression between the first and the second tertiles of LFS. In conclusion, the expressions of galnt2 and sirt1 could be used as early markers of IR, while the expression of ptpn1 could be employed as an early marker of NAFLD.

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  • IPB University
  • Atma Jaya Catholic University of Indonesia
  • Nutrifood
  • Universitas Sumatera Utara
  • University of Indonesia
  • Universitas Pattimura
  • Montana State University
  • Organisasi lain
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
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Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Esti PuspitasariIPB University4
İman RusmanaIPB University4
Nisa Rachmania MubarikIPB University4
Dwi SuryantoUniversitas Sumatera Utara3
Anja MeryandiniIPB University3
Aris Tri WahyudiIPB University3
Andreas Adhi SatyaAfiliasi tidak diketahui3
Widanarni WidanarniIPB University2
Amarila MalikUniversity of Indonesia2
Bibiana W. LayIPB University2
Yulin LestariIPB University2
Dedy Duryadi SolihinIPB University2
Cecilia Anna SeumahuUniversitas Pattimura2
Maria Indah PurnamasariMontana State University2
Rika Indri AstutiIPB University2
Yepy H. RustamAfiliasi tidak diketahui2
Salsabila Permata SariAfiliasi tidak diketahui1
Patricia Roulina PurbaAfiliasi tidak diketahui1
Carissa Ramadhania OktavianiAfiliasi tidak diketahui1
Rendy Dijaya MuliadiAfiliasi tidak diketahui1
Lina AntonoAfiliasi tidak diketahui1
Nurul AiniIPB University1
Walter R. ErdelenIPB University1
Muhammad ZairinIPB University1
Ridwan AffandiIPB University1
Yusminah HalaState University of Makassar1
Sukenda SukendaIPB University1
Budi TjahjonoIPB University1
R. HarlingScottish Agricultural College1
SumardiAfiliasi tidak diketahui1
Maggy T HenawidjajaIPB University1
T Resnawati P UrwadariaAfiliasi tidak diketahui1
Andi KhaeruniUniversitas Halu Oleo1
Budi TjahjonoIPB University1
Meity Suradji SinagaIPB University1
Ari SusilowatiSebelas Maret University1
Suryo WiyonoIPB University1

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Sumber metadata: OAI-PMH (metadata jurnal) https://jurnal.ugm.ac.id/ijbiotech/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Evaluation of potential gene expression as early markers of insulin resistance and non-alcoholic fatty liver disease in the Indonesian population</dc:title>
	<dc:creator>Limantara, Eunice</dc:creator>
	<dc:creator>Kartawidjajaputra, Felicia</dc:creator>
	<dc:creator>Suwanto, Antonius</dc:creator>
	<dc:subject xml:lang="en-US">galnt2; insulin resistance; NAFLD; ptpn1; sirt1</dc:subject>
	<dc:description xml:lang="en-US">Early detection of insulin resistance (IR) or non-alcoholic fatty liver disease (NAFLD) is crucial to preventing future risks of developing chronic diseases. The Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), Liver Fat Score (LFS), and Fatty Liver Index (FLI) are generally employed to measure severity stages of IR and NAFLD. The study of gene expressions could explain the molecular mechanisms that occur early on in IR and NAFLD; thus providing potential early markers for both diseases. This study was conducted to evaluate the gene expressions that could potentially be early markers of IR and NAFLD. All participants (n = 21) had normal blood glucose and were categorized as without hepatosteatosis (n = 10), at higher risk of hepatosteatosis (n = 6), and hepatosteatosis (n = 5). Gene expression analysis was performed using the 2-∆∆CT relative quantification method. There were significant differences in galnt2 (p &lt; 0.002) and sirt1 (p &lt; 0.010) expression between the first and the third tertiles of HOMA-IR; and in ptpn1 (p &lt; 0.012) expression between the first and the second tertiles of LFS. In conclusion, the expressions of galnt2 and sirt1 could be used as early markers of IR, while the expression of ptpn1 could be employed as an early marker of NAFLD.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Gadjah Mada</dc:publisher>
	<dc:contributor xml:lang="en-US">Felicia Kartawidjajaputra, PT Nutrifood Indonesia</dc:contributor>
	<dc:date>2018-12-24</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Original Research Articles</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.ugm.ac.id/ijbiotech/article/view/36975</dc:identifier>
	<dc:identifier>10.22146/ijbiotech.36975</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Biotechnology; Vol 23, No 2 (2018); 84-90</dc:source>
	<dc:source>2089-2241</dc:source>
	<dc:source>0853-8654</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/view/36975/23763</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/36975/5243</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/36975/5244</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/36975/5245</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2018 The Author(s)</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-sa/4.0</dc:rights>
</oai_dc:dc>