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The potential of mesenchymal stem‐cell secretome for regeneration of intervertebral disc: A review article

Indonesian Journal of Biotechnology · Vol. 26 No. 2 (2021) · hlm. 61–75

DOI
10.22146/ijbiotech.63318
ISSN
2089-2241, 0853-8654
Terbit
2021-06-28
Penerbit
Universitas Gadjah Mada
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-sa/4.0

Abstrak

Low back pain is a crucial public health problem that is commonly associated with intervertebral disc de‐ generation and has vast socio‐economic impact worldwide. Current treatments for disc degeneration are conservative, non‐surgical, or surgical interventions, and there is no current clinical therapy aimed at directly reversing the degeneration. Given the limited capacity of intervertebral disc (IVD) cells to self‐repair, treatment aiming to regenerate IVDs is a topic of interest and mesenchymal stem cells (MSCs) have been identified as having potential in this regeneration. Recent studies have revealed that the benefits of MSC therapy could result from the molecules the cells secrete and that play principal roles in regulating essential biologic processes, rather than from the implanted cells themselves. Therefore, the objective of this study is to review the potential use of the MSC secretome to regenerate IVDs. Current evidence shows that the secretome may regenerate IVDs by modulating the gene expressions of nucleus pulposus cells (upregulation of keratin 19 and downregulation of matrix metalloproteinase 12 and matrix Gla protein) and stimulating IVD progenitor cells to repair the degenerated disc.

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  • Universitas Airlangga
  • Bandung Institute of Technology
  • Universitas Jember
  • IPB University
  • RSO Soeharso Surakarta
  • Rumah Sakit Dokter Soetomo
  • Universitas Gadjah Mada
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Rekan penulisOrganisasiArtikel bersama
Kuntoro KuntoroUniversitas Airlangga3
Rachmah IndawatiUniversitas Airlangga2
Farapti FaraptiUniversitas Airlangga2
Chatarina Umbul WahyuniUniversitas Airlangga2
Lilis SulistyoriniUniversitas Airlangga2
Kusnoto KusnotoUniversitas Airlangga2
Jola RahmahaniUniversitas Airlangga2
Dwi - KuswantoUniversitas Airlangga1
Annisaa Wulida FurqoniaUniversitas Airlangga1
Retno Pudji RahayuUniversitas Airlangga1
Sri HernawatiUniversitas Jember1
I Ketut SudianaUniversitas Airlangga1
F. FerdiansyahRumah Sakit Dokter Soetomo1
Desi Sandra SariUniversitas Jember1
Ernie MaduratnaUniversitas Airlangga1
I Ketut SudianaUniversitas Airlangga1
Diah RatnadewiIPB University1
Atik Choirul HidajahUniversitas Airlangga1
Ika Dewi AnaUniversitas Gadjah Mada1
Christofora Hanny WidjajaIPB University1
Anggraini BarlianBandung Institute of Technology1
Rizka Musdalifah AmsarBandung Institute of Technology1
Triati Dewi Kencana WunguBandung Institute of Technology1
Mochammad Bagus QomaruddinUniversitas Airlangga1
Apik Indarty MoedjionoHasanuddin University1
Nursalam NursalamUniversitas Airlangga1
Fery Agusman Motuho MendrofaUniversitas Karya Husada Semarang1
Hasan MachfoedUniversitas Airlangga1
Rachmad HargonoUniversitas Airlangga1
Bagus WidjonarkoDiponegoro University1
Efri Tri ArdiantoUniversitas Airlangga1
Windhu PurnomoUniversitas Airlangga1

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Sumber metadata: OAI-PMH (metadata jurnal) https://jurnal.ugm.ac.id/ijbiotech/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">The potential of mesenchymal stem‐cell secretome for regeneration of intervertebral disc: A review article</dc:title>
	<dc:creator>Romaniyanto, Romaniyanto</dc:creator>
	<dc:creator>Prakoeswa, Cita Rosita Sigit</dc:creator>
	<dc:creator>Tinduh, Damayanti</dc:creator>
	<dc:creator>Notobroto, Hari Basuki</dc:creator>
	<dc:creator>Rantam, Fedik Abdul</dc:creator>
	<dc:creator>Utomo, Dwikora Novembri</dc:creator>
	<dc:creator>Suroto, Heri</dc:creator>
	<dc:creator>Ferdiansyah, Ferdiansyah</dc:creator>
	<dc:subject xml:lang="en-US">Intervertebral disc degeneration; low back pain; mesenchymal stem cells; regenerative properties; secretome</dc:subject>
	<dc:description xml:lang="en-US">Low back pain is a crucial public health problem that is commonly associated with intervertebral disc de‐ generation and has vast socio‐economic impact worldwide. Current treatments for disc degeneration are conservative, non‐surgical, or surgical interventions, and there is no current clinical therapy aimed at directly reversing the degeneration. Given the limited capacity of intervertebral disc (IVD) cells to self‐repair, treatment aiming to regenerate IVDs is a topic of interest and mesenchymal stem cells (MSCs) have been identified as having potential in this regeneration. Recent studies have revealed that the benefits of MSC therapy could result from the molecules the cells secrete and that play principal roles in regulating essential biologic processes, rather than from the implanted cells themselves. Therefore, the objective of this study is to review the potential use of the MSC secretome to regenerate IVDs. Current evidence shows that the secretome may regenerate IVDs by modulating the gene expressions of nucleus pulposus cells (upregulation of keratin 19 and downregulation of matrix metalloproteinase 12 and matrix Gla protein) and stimulating IVD progenitor cells to repair the degenerated disc.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Gadjah Mada</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2021-06-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Original Research Articles</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.ugm.ac.id/ijbiotech/article/view/63318</dc:identifier>
	<dc:identifier>10.22146/ijbiotech.63318</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Biotechnology; Vol 26, No 2 (2021); 61-75</dc:source>
	<dc:source>2089-2241</dc:source>
	<dc:source>0853-8654</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/view/63318/31444</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/63318/15127</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/63318/15128</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/63318/15129</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/63318/15130</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2021 The Author(s)</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-sa/4.0</dc:rights>
</oai_dc:dc>