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Spatial learning and memory of young and aging rats following injection with human Wharton’s jelly‐mesenchymal stem cells

Indonesian Journal of Biotechnology · Vol. 26 No. 2 (2021) · hlm. 91–100

DOI
10.22146/ijbiotech.64734
ISSN
2089-2241, 0853-8654
Terbit
2021-06-28
Penerbit
Universitas Gadjah Mada
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-sa/4.0

Abstrak

Human Wharton’s jelly‐mesenchymal stem cells (hWJ‐MSC) are an emerging potential source of stem cells derived from the umbilical cord. Previous studies have shown their potential as treatment for traumatic brain injury and Parkinson’s disease. However, no study has yet investigated the effect of hWJ‐MSC injections in countering spatial learning and memory impairment in aging rats. The effect of hWJ‐MSC injection on young rats is also unknown. The objective of this research was to analyze the effect of an hWJ‐MSC injection on spatial learning, memory, density of putative neural progenitor cells (pNPC), and neuronal apoptosis in the dentate gyrus (DG) of young and aging rats. Injection of hWJ‐MSC did not change spatial learning and memory in young rats until two months post‐injection. This might be due to retained pNPC density and neuronal apoptosis in the DG of young rats after injection of hWJ‐MSC. In contrast, injection of hWJ‐MSC promoted both spatial learning and memory in aging rats, a finding that might be attributable to the increased pNPC density and attenuated neuronal apoptosis in DG of aging rats during the two months post‐injection. Our study suggests that a single injection of hWJ‐MSC might be sufficient to promote improvement in long‐term learning and memory in aging rats.

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  • Universitas Halu Oleo
  • Universitas Negeri Surabaya
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Rekan penulisOrganisasiArtikel bersama
Mokhamad FahrudinAfiliasi tidak diketahui5
Wahyu WidowatiAfiliasi tidak diketahui5
Adi WinartoAfiliasi tidak diketahui4
Rizal RizalUniversitas Halu Oleo4
Annisa AmaliaAfiliasi tidak diketahui4
Dwi Davidson RihibihaAfiliasi tidak diketahui4
Ervi AfifahAfiliasi tidak diketahui4
Muhammad RizalUniversitas Halu Oleo3
HERDISAfiliasi tidak diketahui3
Mohamad Agus SetiadiAfiliasi tidak diketahui3
Srihadi AgungpriyonoAfiliasi tidak diketahui3
RIKA RAFFIUDINAfiliasi tidak diketahui3
Windra PriawandiputraAfiliasi tidak diketahui3
Vista BudiariatiAfiliasi tidak diketahui3
Dwi BudionoAfiliasi tidak diketahui3
Aryani Sismin SatyaningtijasAfiliasi tidak diketahui3
Resti Rahma DiantiAfiliasi tidak diketahui3
Alif Iman FitriantoAfiliasi tidak diketahui3
Adkhilni UtamiAfiliasi tidak diketahui3
Wining AstiniAfiliasi tidak diketahui3
Adisti DwijayantiAfiliasi tidak diketahui3
Frans Dhyanagiri SuyatnaAfiliasi tidak diketahui3
Sutiman Bambang SumitroAfiliasi tidak diketahui3
Diana Krisanti JasaputraAfiliasi tidak diketahui3
ITA DJUWITAAfiliasi tidak diketahui2
Takdir SailiAfiliasi tidak diketahui2
. YulnawatiAfiliasi tidak diketahui2
Fahri FahriUniversitas Negeri Surabaya2
Tri AtmowidiAfiliasi tidak diketahui2
Nisfia Rakhmatun NisaAfiliasi tidak diketahui2
Dani Al MahkyaAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://jurnal.ugm.ac.id/ijbiotech/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Spatial learning and memory of young and aging rats following injection with human Wharton’s jelly‐mesenchymal stem cells</dc:title>
	<dc:creator>Juliandi, Berry</dc:creator>
	<dc:creator>Mubarok, Wildan</dc:creator>
	<dc:creator>Anggraini, Dian</dc:creator>
	<dc:creator>Boediono, Arief</dc:creator>
	<dc:creator>Subangkit, Mawar</dc:creator>
	<dc:creator>Bachtiar, Indra</dc:creator>
	<dc:creator>Murti, Harry</dc:creator>
	<dc:creator>Yaprianto, Kelvin</dc:creator>
	<dc:creator>Setiawan, Boenjamin</dc:creator>
	<dc:subject xml:lang="en-US">Human Wharton’s jelly‐mesenchymal stem cells (hWJ‐MSCs); learning; memory; neurogenesis; stem cells</dc:subject>
	<dc:description xml:lang="en-US">Human Wharton’s jelly‐mesenchymal stem cells (hWJ‐MSC) are an emerging potential source of stem cells derived from the umbilical cord. Previous studies have shown their potential as treatment for traumatic brain injury and Parkinson’s disease. However, no study has yet investigated the effect of hWJ‐MSC injections in countering spatial learning and memory impairment in aging rats. The effect of hWJ‐MSC injection on young rats is also unknown. The objective of this research was to analyze the effect of an hWJ‐MSC injection on spatial learning, memory, density of putative neural progenitor cells (pNPC), and neuronal apoptosis in the dentate gyrus (DG) of young and aging rats. Injection of hWJ‐MSC did not change spatial learning and memory in young rats until two months post‐injection. This might be due to retained pNPC density and neuronal apoptosis in the DG of young rats after injection of hWJ‐MSC. In contrast, injection of hWJ‐MSC promoted both spatial learning and memory in aging rats, a finding that might be attributable to the increased pNPC density and attenuated neuronal apoptosis in DG of aging rats during the two months post‐injection. Our study suggests that a single injection of hWJ‐MSC might be sufficient to promote improvement in long‐term learning and memory in aging rats.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Gadjah Mada</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2021-06-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Original Research Articles</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.ugm.ac.id/ijbiotech/article/view/64734</dc:identifier>
	<dc:identifier>10.22146/ijbiotech.64734</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Biotechnology; Vol 26, No 2 (2021); 91-100</dc:source>
	<dc:source>2089-2241</dc:source>
	<dc:source>0853-8654</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/view/64734/31464</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/64734/15908</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/64734/15909</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/64734/15910</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/64734/15911</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/64734/15912</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/64734/15913</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2021 The Author(s)</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-sa/4.0</dc:rights>
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