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Moringa oleifera leaf extract ameliorates collagen degradation via the inhibition of MMP‐3 expression in UVB‐induced rats

Indonesian Journal of Biotechnology · Vol. 29 No. 3 (2024) · hlm. 121–128

DOI
10.22146/ijbiotech.77538
ISSN
2089-2241, 0853-8654
Terbit
2024-09-30
Penerbit
Universitas Gadjah Mada
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-sa/4.0

Abstrak

Prolonged exposure to high‐intensity UVB induces the formation of reactive oxygen species (ROS) in skin tissue, triggering an increase in matrix metalloproteinase‐3 (MMP‐3) enzyme production and leading to collagen degradation. Moringa oleifera (MO) contains bioactive compounds known for ROS‐scavenging and anti‐inflammatory properties. However, the precise molecular mechanism of action remains unclear, requiring the inhibition of MMP‐3 activation and regulation of collagen deposition. This study aims to elucidate the potential effect of MO leaf extract‐based gel in restoring collagen deposition by reducing MMP‐3 activation in UVB irradiate‐induced collagen loss in rats. This study employed a completely randomized design, comprising four groups: a healthy group without UVB radiation, a negative control group subjected to UVB radiation and receiving a placebo, and two treatment groups exposed to UVB radiation with 5% or 10% moringa leaf extract‐based gel (MO‐5% or MO‐10%), respectively. Results showed that MO‐5% and MO‐10% significantly reduced MMP‐3 gene expression and increased collagen density compared to the negative control group (p < 0.05). Moringa oleifera leaf extract ameliorates collagen degradation by inhibiting MMP‐3 expression in UVB‐induced rats, suggesting its potential as a pharmacological and cosmetic agent for UVB‐induced skin damage.

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  • Hasanuddin University
  • Institut Teknologi Kalimantan
  • University of Brawijaya
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Rekan penulisOrganisasiArtikel bersama
Nur Dina AmalinaAfiliasi tidak diketahui5
Chodijah ChodijahAfiliasi tidak diketahui4
Adi Muradi MuharAfiliasi tidak diketahui4
Bayu Tirta DirjaAfiliasi tidak diketahui4
Sugeng IbrahimAfiliasi tidak diketahui3
Eko SetiawanUniversity of Brawijaya3
Sri Priyantini MulyaniAfiliasi tidak diketahui2
Setyo TrisnadiAfiliasi tidak diketahui2
Destyariani Liana PutriInstitut Teknologi Kalimantan1
Muhammad Khaisar WirawanInstitut Teknologi Kalimantan1
Nurul HidayahInstitut Teknologi Kalimantan1
Siti SulemanAfiliasi tidak diketahui1
Andhika Hayyu PratamaAfiliasi tidak diketahui1
Fabelyn Gandryal MistipaAfiliasi tidak diketahui1
Muhammad Fakhri ArdyansyahAfiliasi tidak diketahui1
Hans Julio PratamaAfiliasi tidak diketahui1
Fabelyn Gandryal Mistipa AvinHasanuddin University1
Siti Arifaini SulemanHasanuddin University1
Andhika Hayyu PratamaHasanuddin University1
Muhammad Fakhri ArdyansyahHasanuddin University1
Nurul HidayahHasanuddin University1
Hans Julio PratamaHasanuddin University1
Nurfadilah NurfadilahHasanuddin University1
Dinil QaiyimahAfiliasi tidak diketahui1
Nasrul NasrulAfiliasi tidak diketahui1
Mohamad MuspawiAfiliasi tidak diketahui1
Firman FirmanHasanuddin University1
Arda Trisnawaty PanjaitanAfiliasi tidak diketahui1
Fanny Angelika ManullangAfiliasi tidak diketahui1
Friska Mawira ManullangAfiliasi tidak diketahui1
Widya Patricia Utama NahampunAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://jurnal.ugm.ac.id/ijbiotech/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Moringa oleifera leaf extract ameliorates collagen degradation via the inhibition of MMP‐3 expression in UVB‐induced rats</dc:title>
	<dc:creator>Rachmania, Riska</dc:creator>
	<dc:creator>Sumarawati, Titiek</dc:creator>
	<dc:creator>Putra, Agung</dc:creator>
	<dc:creator>Hidayah, Nurul</dc:creator>
	<dc:creator>Alif, Iffan</dc:creator>
	<dc:creator>Husain, Sofian Azalia</dc:creator>
	<dc:creator>Mukti, Ade Indra</dc:creator>
	<dc:creator>Suryajaya, Reynaldi</dc:creator>
	<dc:creator>Azzahara, Salma Yasmine</dc:creator>
	<dc:subject xml:lang="en-US">Collagen; MMP‐3; Moringa oleifera; UVB exposure</dc:subject>
	<dc:description xml:lang="en-US">Prolonged exposure to high‐intensity UVB induces the formation of reactive oxygen species (ROS) in skin tissue, triggering an increase in matrix metalloproteinase‐3 (MMP‐3) enzyme production and leading to collagen degradation. Moringa oleifera (MO) contains bioactive compounds known for ROS‐scavenging and anti‐inflammatory properties. However, the precise molecular mechanism of action remains unclear, requiring the inhibition of MMP‐3 activation and regulation of collagen deposition. This study aims to elucidate the potential effect of MO leaf extract‐based gel in restoring collagen deposition by reducing MMP‐3 activation in UVB irradiate‐induced collagen loss in rats. This study employed a completely randomized design, comprising four groups: a healthy group without UVB radiation, a negative control group subjected to UVB radiation and receiving a placebo, and two treatment groups exposed to UVB radiation with 5% or 10% moringa leaf extract‐based gel (MO‐5% or MO‐10%), respectively. Results showed that MO‐5% and MO‐10% significantly reduced MMP‐3 gene expression and increased collagen density compared to the negative control group (p &lt; 0.05). Moringa oleifera leaf extract ameliorates collagen degradation by inhibiting MMP‐3 expression in UVB‐induced rats, suggesting its potential as a pharmacological and cosmetic agent for UVB‐induced skin damage.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Gadjah Mada</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2024-09-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Original Research Articles</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.ugm.ac.id/ijbiotech/article/view/77538</dc:identifier>
	<dc:identifier>10.22146/ijbiotech.77538</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Biotechnology; Vol 29, No 3 (2024); 121-128</dc:source>
	<dc:source>2089-2241</dc:source>
	<dc:source>0853-8654</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/view/77538/40154</dc:relation>
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	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/77538/23074</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/77538/23075</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/77538/23076</dc:relation>
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	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/77538/23079</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2024 The Author(s)</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-sa/4.0</dc:rights>
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