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Protective effects of Zingiber cassumunar Roxb. extract against UVB‐induced oxidative stress in Wistar albino rats (Rattus novergicus Berkenhout, 1769)

Indonesian Journal of Biotechnology · Vol. 29 No. 1 (2024) · hlm. 25–32

DOI
10.22146/ijbiotech.90224
ISSN
2089-2241, 0853-8654
Terbit
2024-03-30
Penerbit
Universitas Gadjah Mada
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-sa/4.0

Abstrak

Protecting the skin from the effects of UVB radiation using natural products is crucial in the cosmeceutical industry. This study aims to investigate the protective effects of Bangle (Zingiber cassumunar Roxb.) against UVB‐induced skin damage in Wistar albino rats. The rhizomes were macerated using 70% ethanol v/v, followed by n‐hexane to obtain n‐hexane soluble and n‐hexane insoluble fraction. The antioxidant properties of the ethanol extracts and n‐hexane soluble fraction were evaluated using a 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) assay. The study also examined the antiphotoaging properties through reactive oxygen species (ROS) scavenging assay, matrix metalloproteinase‐1 (MMP‐1) expression, and tyrosinase expression against UVB radiation in Wistar albino rats. The results demonstrated that the Z. cassumunar extract and fraction effectively converted DPPH radicals into a more stable compound. Analysis revealed the presence of Benzene, 4‐(1Z)‐1,3‐butadien‐1‐yl‐1,2‐dimethoxy‐ and (E)‐4‐(3,4‐Dimethoxyphenyl) but‐3‐en‐1‐ol as the primary compounds in both the extract and fraction, suggesting their contribution to the observed activity. Furthermore, Z. cassumunar compounds could reduce UVB‐induced ROS production and may protect against skin photoaging by changing the expression of MMP‐1 and tyrosinase levels in Wistar albino rats. These findings suggest that Z. cassumunar holds promise for preventing skin aging.

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  • Universitas Gadjah Mada
  • Amélioration Génétique et Adaptation des Plantes méditerranéennes et tropicales
  • Justus-Liebig-Universität Gießen
  • Jenderal Soedirman University
  • Universitas Teuku Umar
  • King Saud University
  • Universitas Islam Negeri Ar-Raniry
  • Organisasi lain
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
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Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Aris Tri HaryantoUniversitas Gadjah Mada7
Tri WibawaUniversitas Gadjah Mada4
Michael KannJustus-Liebig-Universität Gießen3
Jaka WidadaUniversitas Gadjah Mada2
Puji AstutiUniversitas Gadjah Mada2
Yekti Asih PurwestriUniversitas Gadjah Mada2
Hevi WihadmadyatamiUniversitas Gadjah Mada2
Lisna HidayatiUniversitas Gadjah Mada2
Sofia MubarikaUniversitas Gadjah Mada2
Rarastoeti PratiwiUniversitas Gadjah Mada2
Diani MentariJenderal Soedirman University1
Rinawati RinawatiUniversitas Teuku Umar1
E. SuharyantoUniversitas Gadjah Mada1
Ririn SuharsantiAfiliasi tidak diketahui1
Nunung YuniartiUniversitas Gadjah Mada1
S. M. WidyastutiUniversitas Gadjah Mada1
Etik Erna Wati HadiAfiliasi tidak diketahui1
Abdulrahman S. AldawoodKing Saud University1
Siti Shofa Assyifa’ul Qulbi BaridUniversitas Gadjah Mada1
Fathur Syahrian RamadhaniUniversitas Gadjah Mada1
Hari PurwantoUniversitas Gadjah Mada1
Hendry T.S.S.G. SaragihUniversitas Gadjah Mada1
SukirnoUniversitas Gadjah Mada1
Muhammad AdnanUniversitas Islam Negeri Ar-Raniry1
Matin NuhamunadaUniversitas Gadjah Mada1
Siti SubandiyahUniversitas Gadjah Mada1
Junaidi JunaidiAmélioration Génétique et Adaptation des Plantes méditerranéennes et tropicales1
Anne Clément‐VidalAmélioration Génétique et Adaptation des Plantes méditerranéennes et tropicales1
Éric GohetABSys1
Pascal MontoroAmélioration Génétique et Adaptation des Plantes méditerranéennes et tropicales1
Hera NirwatiUniversitas Gadjah Mada1
Sp.A SutaryoUniversitas Gadjah Mada1
Nenny Sri MulyaniAfiliasi tidak diketahui1
Titis Budi WidowatiAfiliasi tidak diketahui1
Purnomo HadiAfiliasi tidak diketahui1
Abdul Rahman SiregarUniversitas Gadjah Mada1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) https://jurnal.ugm.ac.id/ijbiotech/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Protective effects of Zingiber cassumunar Roxb. extract against UVB‐induced oxidative stress in Wistar albino rats (Rattus novergicus Berkenhout, 1769)</dc:title>
	<dc:creator>Tyas, Dian Ayuning</dc:creator>
	<dc:creator>Wijayanti, Nastiti</dc:creator>
	<dc:creator>Nuringtyas, Tri Rini</dc:creator>
	<dc:creator>Wahyuono, Subagus</dc:creator>
	<dc:subject xml:lang="en-US">Matrix metalloproteinase; Skin photoaging; Ultraviolet B; Zingiber cassumunar</dc:subject>
	<dc:description xml:lang="en-US">Protecting the skin from the effects of UVB radiation using natural products is crucial in the cosmeceutical industry. This study aims to investigate the protective effects of Bangle (Zingiber cassumunar Roxb.) against UVB‐induced skin damage in Wistar albino rats. The rhizomes were macerated using 70% ethanol v/v, followed by n‐hexane to obtain n‐hexane soluble and n‐hexane insoluble fraction. The antioxidant properties of the ethanol extracts and n‐hexane soluble fraction were evaluated using a 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) assay. The study also examined the antiphotoaging properties through reactive oxygen species (ROS) scavenging assay, matrix metalloproteinase‐1 (MMP‐1) expression, and tyrosinase expression against UVB radiation in Wistar albino rats. The results demonstrated that the Z. cassumunar extract and fraction effectively converted DPPH radicals into a more stable compound. Analysis revealed the presence of Benzene, 4‐(1Z)‐1,3‐butadien‐1‐yl‐1,2‐dimethoxy‐ and (E)‐4‐(3,4‐Dimethoxyphenyl) but‐3‐en‐1‐ol as the primary compounds in both the extract and fraction, suggesting their contribution to the observed activity. Furthermore, Z. cassumunar compounds could reduce UVB‐induced ROS production and may protect against skin photoaging by changing the expression of MMP‐1 and tyrosinase levels in Wistar albino rats. These findings suggest that Z. cassumunar holds promise for preventing skin aging.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Gadjah Mada</dc:publisher>
	<dc:contributor xml:lang="en-US">Indonesian Endowment Fund for Education (LPDP)</dc:contributor>
	<dc:date>2024-03-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Original Research Articles</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.ugm.ac.id/ijbiotech/article/view/90224</dc:identifier>
	<dc:identifier>10.22146/ijbiotech.90224</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Biotechnology; Vol 29, No 1 (2024); 25-32</dc:source>
	<dc:source>2089-2241</dc:source>
	<dc:source>0853-8654</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/view/90224/38825</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2024 The Author(s)</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-sa/4.0</dc:rights>
</oai_dc:dc>