Melola Discovery

← Melola Discovery

Akses terbuka Jurnal SINTA 1

Enhanced erythritol production by UV-mutated Yarrowia lipolytica and Moniliella pollinis using glucose and molasses as carbon sources

Indonesian Journal of Biotechnology · Vol. 31 No. 2 (2026) · hlm. 85–96

DOI
10.22146/ijbiotech.90540
ISSN
2089-2241, 0853-8654
Terbit
2026-06-30
Penerbit
Universitas Gadjah Mada
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-sa/4.0

Abstrak

Erythritol, a sugar alcohol, is commercially produced through fermentation. Yarrowia lipolytica and Moniliella pollinis serve as efficient erythritol producers due to their osmotic tolerance. Optimizing the cost-effectiveness of erythritol production involves harnessing strains capable of utilizing low-cost carbon sources. This study examines the impact of two different carbon sources (glucose and molasses) on the growth and erythritol production of native and UV-induced mutant strains of Y. lipolytica and M. pollinis. In the glucose-based medium (GYM), the M. pollinis SP5 mutant strain achieved the highest erythritol biosynthesis, with a yield mass of 0.275 g/g and a volumetric productivity of 0.052 g/L/h, while in the molasses-based medium (MYM), it attained a yield mass of 0.120 g/g and a volumetric productivity of 0.065 g/L/h. Random mutagenesis might improve erythritol biosynthesis by increasing enzyme activity and altering carbon flux. Molasses emerged as a potential carbon source for M. pollinis, which favors sucrose hydrolysis and glucose metabolism for erythritol production. To further enhance erythritol yield with M. pollinis, it is advisable to increase the concentration of molasses, adjust the carbon-to-nitrogen (C/N) ratio in the MYM medium, and optimize the fermentation systems.

Kata kunci

Jaringan kolaborasi para penulis

30 penulis · 159 tautan kepenulisan bersama · 65 lintas organisasi

Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.

  • Indonesia International Institute for Life Sciences
  • National Research and Innovation Agency
  • International Center for Biotechnology, The University of Osaka
  • University of Warwick
  • Indonesian Institute of Sciences
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
  • Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel
Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Jocelyn NatanielInternational Center for Biotechnology, The University of Osaka2
Amelia HalimIndonesia International Institute for Life Sciences1
Albert RidwanIndonesia International Institute for Life Sciences1
Celine GozalIndonesia International Institute for Life Sciences1
Sidney Laura WongIndonesia International Institute for Life Sciences1
Kenneth Gabriel YoungIndonesia International Institute for Life Sciences1
Jeffersen Hosea SetiabangIndonesia International Institute for Life Sciences1
Michael Ryan FildyIndonesia International Institute for Life Sciences1
Kezia Zefanya LimawanIndonesia International Institute for Life Sciences1
Advent Roan WidiyonoIndonesia International Institute for Life Sciences1
Nathanael Darrell YonasIndonesia International Institute for Life Sciences1
Indra Kurniawan SaputraUniversity of Warwick1
Dadang SupriatnaNational Research and Innovation Agency1
Wien KusharyotoIndonesian Institute of Sciences1
Endah Puji SeptisetyaniNational Research and Innovation Agency1
Ratna Dwi RamadaniNational Research and Innovation Agency1
Yana RubiyanaNational Research and Innovation Agency1
Pekik Wiji PrasetyaningrumNational Research and Innovation Agency1
Popi Hadi WisnuwardhaniNational Research and Innovation Agency1
Ratih Asmana NingrumNational Research and Innovation Agency1
Dian Fitria AgustiyantiNational Research and Innovation Agency1
Andri WardianaNational Research and Innovation Agency1
Gracia Christine Lembong PurwantoIndonesia International Institute for Life Sciences1
Fedric Intan DamaiIndonesia International Institute for Life Sciences1
Alfi Taufik FathurahmanNational Research and Innovation Agency1
Muhammad Khairul Lisan SidqiNational Research and Innovation Agency1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) https://jurnal.ugm.ac.id/ijbiotech/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Enhanced erythritol production by UV-mutated Yarrowia lipolytica and Moniliella pollinis using glucose and molasses as carbon sources</dc:title>
	<dc:creator>Kembaren, Riahna</dc:creator>
	<dc:creator>Natasya, Regina</dc:creator>
	<dc:creator>Pramanda, Ihsan Tria</dc:creator>
	<dc:creator>Aslanzadeh, Solmaz</dc:creator>
	<dc:subject xml:lang="en-US">Erythritol; Molasses; Moniliella pollinis; Random mutagenesis; Yarrowia lipolytica</dc:subject>
	<dc:description xml:lang="en-US">Erythritol, a sugar alcohol, is commercially produced through fermentation. Yarrowia lipolytica and Moniliella pollinis serve as efficient erythritol producers due to their osmotic tolerance. Optimizing the cost-effectiveness of erythritol production involves harnessing strains capable of utilizing low-cost carbon sources. This study examines the impact of two different carbon sources (glucose and molasses) on the growth and erythritol production of native and UV-induced mutant strains of Y. lipolytica and M. pollinis. In the glucose-based medium (GYM), the M. pollinis SP5 mutant strain achieved the highest erythritol biosynthesis, with a yield mass of 0.275 g/g and a volumetric productivity of 0.052 g/L/h, while in the molasses-based medium (MYM), it attained a yield mass of 0.120 g/g and a volumetric productivity of 0.065 g/L/h. Random mutagenesis might improve erythritol biosynthesis by increasing enzyme activity and altering carbon flux. Molasses emerged as a potential carbon source for M. pollinis, which favors sucrose hydrolysis and glucose metabolism for erythritol production. To further enhance erythritol yield with M. pollinis, it is advisable to increase the concentration of molasses, adjust the carbon-to-nitrogen (C/N) ratio in the MYM medium, and optimize the fermentation systems.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Gadjah Mada</dc:publisher>
	<dc:contributor xml:lang="en-US">This work was supported by the Fundamental Research Grant from the Directorate General of Higher Education, Research, and Technology (DIKTI), Indonesian Ministry of Education, Culture, Research and Technology, contract No.179/E5/PG.02.00/PL/2023.</dc:contributor>
	<dc:date>2026-06-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Original Research Articles</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.ugm.ac.id/ijbiotech/article/view/90540</dc:identifier>
	<dc:identifier>10.22146/ijbiotech.90540</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Biotechnology; Vol 31, No 2 (2026); 85–96</dc:source>
	<dc:source>2089-2241</dc:source>
	<dc:source>0853-8654</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/view/90540/44363</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/view/90540/44361</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29828</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29829</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29830</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29831</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29832</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29833</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29834</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29835</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29836</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29837</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29838</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29839</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29840</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29841</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29842</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29843</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29844</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29845</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29846</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29847</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29848</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29849</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29850</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29851</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29852</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29853</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29854</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29855</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29857</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29858</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29859</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29860</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29861</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29862</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29864</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/29865</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/90540/31716</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2026 The Author(s)</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-sa/4.0</dc:rights>
</oai_dc:dc>