The therapeutic potential of dental pulp mesenchymal stem cells and the emerging role of stem cell-based therapies in periodontal disease

Putri, Karina Pratiwi; Rayanti, Rike; Sumarwoto, Tito

doi:10.22146/ijbiotech.111492

Akses terbuka Jurnal SINTA 1

The therapeutic potential of dental pulp mesenchymal stem cells and the emerging role of stem cell-based therapies in periodontal disease

Indonesian Journal of Biotechnology · Vol. 31 No. 3 (2026) · hlm. 198–212

DOI: 10.22146/ijbiotech.111492
ISSN: 2089-2241, 0853-8654
Terbit: 2026-09-30
Penerbit: Universitas Gadjah Mada
Bahasa: eng
Lisensi: creativecommons.org/licenses/by-sa/4.0

Abstrak

Periodontal disease is a chronic inflammatory condition that destroys the supporting structures of the teeth and is not predictably restored by conventional therapies using mechanical debridement and surgery alone. Dental pulp mesenchymal stem cells represent a relatively accessible and ethically acceptable source of multipotent cells with strong regenerative and immunomodulatory properties that may better address this unmet clinical need. This review aims to synthesize and critically appraise recent in vitro, animal and human studies on the use of dental pulp mesenchymal stem cells for periodontal regeneration, highlighting their biological characteristics, mechanisms of action within the inflamed periodontal environment, and translational relevance compared with other stem cell sources. Experimental evidence shows that these cells contribute to the formation of new bone, cementum and periodontal ligament, while reducing inflammation and enhancing angiogenesis and tissue remodeling. Early clinical applications also suggest improvements in clinical attachment, probing depth and radiographic bone fill without major short-term safety concerns. Overall, dental pulp mesenchymal stem cells appear to be a promising therapeutic option for true periodontal tissue regeneration, but robust, large-scale, long-term clinical trials, together with standardized protocols for cell preparation and delivery, are still required before they can be recommended for routine clinical use.

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11 penulis · 26 tautan kepenulisan bersama · 12 lintas organisasi

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Sebelas Maret University
RSO Soeharso Surakarta
Universitas Gadjah Mada
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Tampilkan sebagai tabel

Rekan penulis	Organisasi	Artikel bersama
Pamudji Utomo	RSO Soeharso Surakarta	1
M qathar Rf Tulandi Tulandi	Sebelas Maret University	1
Rahmad Rian	Sebelas Maret University	1
Seti Aji Hadinoto	RSO Soeharso Surakarta	1
Asep Santoso	Sebelas Maret University	1
Mujaddid Idulhaq	Sebelas Maret University	1
Romaniyanto	Sebelas Maret University	1
Sholahuddin Rhamtomy	Universitas Gadjah Mada	1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) https://jurnal.ugm.ac.id/ijbiotech/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.

Metadata asli (oai_dc)

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	<dc:title xml:lang="en-US">The therapeutic potential of dental pulp mesenchymal stem cells and the emerging role of stem cell-based therapies in periodontal disease</dc:title>
	<dc:creator>Putri, Karina Pratiwi</dc:creator>
	<dc:creator>Rayanti, Rike</dc:creator>
	<dc:creator>Sumarwoto, Tito</dc:creator>
	<dc:subject xml:lang="en-US">Cell-based treatment; Dental pulp stem cells; Periodontal disease; Regenerative therapy; Tissue engineering</dc:subject>
	<dc:description xml:lang="en-US">Periodontal disease is a chronic inflammatory condition that destroys the supporting structures of the teeth and is not predictably restored by conventional therapies using mechanical debridement and surgery alone. Dental pulp mesenchymal stem cells represent a relatively accessible and ethically acceptable source of multipotent cells with strong regenerative and immunomodulatory properties that may better address this unmet clinical need. This review aims to synthesize and critically appraise recent in vitro, animal and human studies on the use of dental pulp mesenchymal stem cells for periodontal regeneration, highlighting their biological characteristics, mechanisms of action within the inflamed periodontal environment, and translational relevance compared with other stem cell sources. Experimental evidence shows that these cells contribute to the formation of new bone, cementum and periodontal ligament, while reducing inflammation and enhancing angiogenesis and tissue remodeling. Early clinical applications also suggest improvements in clinical attachment, probing depth and radiographic bone fill without major short-term safety concerns. Overall, dental pulp mesenchymal stem cells appear to be a promising therapeutic option for true periodontal tissue regeneration, but robust, large-scale, long-term clinical trials, together with standardized protocols for cell preparation and delivery, are still required before they can be recommended for routine clinical use.</dc:description>
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	<dc:date>2026-09-30</dc:date>
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	<dc:source xml:lang="en-US">Indonesian Journal of Biotechnology; Vol 31, No 3 (2026); 198–212</dc:source>
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	<dc:source>0853-8654</dc:source>
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	<dc:rights xml:lang="en-US">Copyright (c) 2026 The Author(s)</dc:rights>
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