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Combination of Solanum nigrum L. Herb Ethanolic Extract and Doxorubicin Performs Synergism on T47D Breast Cancer Cells

Indonesian Journal of Cancer Chemoprevention · Vol. 1 No. 2 (2010) · hlm. 78–84

DOI
10.14499/indonesianjcanchemoprev1iss2pp78-84
ISSN
2355-8989, 2088-0197
Terbit
2010-06-30
Penerbit
Indonesian Society for Cancer Chemoprevention
Bahasa
eng

Abstrak

Leunca (Solanum nigrum L.) has been proven to possess anticancer activity on some type of cancer cells. In vitro study of solamargine found in the herb showed cytotoxic effect against several breast cancer cell lines, such as T47D and MDA-MB-31. Hence, further study on its potential as a co-chemotherapeutic agent needs to be conducted, in order to overcome resistance problem commonly found in cancer chemotherapy. This study aimed to examine the cytotoxic activity of leunca herb ethanolic extract (LEE) alone and its combination with doxorubicin. Single and combinational treatment of LEE and doxorubicin on T47D breast cancer cells were done, and their viability representing cytotoxicity were analyzed by using MTT assay to determine the IC50 value and combination index (CI) to evaluate the combinational effect. Twenty four hours-treatment of LEE alone gave cytotoxicity activity showing a dose-dependent manner with the IC50 of 47 µg/ml, while combinational treatment showed that 4 µg/ml LEE was found to be synergist with 4 nM doxorubicin on T47D cells, with the optimum CI value of 0.59. This result shows that Solanum nigrum L. is potential to be proposed as doxorubicin co-chemotherapeutic agent against breast cancer. Further study on its molecular mechanism needs to be conducted.Key words: Solanum nigrum, doxorubicin, synergist, breast cancer

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  • Universitas Gadjah Mada
  • Indonesian Institute of Sciences
  • Jenderal Soedirman University
  • Sumatera Institute of Technology
  • Kementerian Kesehatan Republik Indonesia
  • Nara Institute of Science and Technology
  • Atma Jaya University Yogyakarta
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Rekan penulisOrganisasiArtikel bersama
Ratna Asmah SusidartiUniversitas Gadjah Mada20
Riris Istighfari JenieUniversitas Gadjah Mada18
Muthi IkawatiUniversitas Gadjah Mada16
Rohmad Yudi UtomoUniversitas Gadjah Mada13
Faaza Aulia RahmanUniversitas Gadjah Mada6
Erlina RivantiUniversitas Gadjah Mada6
Sari HaryantiKementerian Kesehatan Republik Indonesia5
Dhania NovitasariUniversitas Gadjah Mada5
Desty Restia RahmawatiUniversitas Gadjah Mada5
Aditya FitriasariUniversitas Gadjah Mada5
Retno MurwantiUniversitas Gadjah Mada4
Ummi Maryam ZulfinUniversitas Gadjah Mada4
Larasati LarasatiUniversitas Gadjah Mada4
Lailatul QodriaUniversitas Gadjah Mada4
Gergorius Gena MaranUniversitas Gadjah Mada4
Yurista GilangUniversitas Gadjah Mada4
Herwandhani PutriUniversitas Gadjah Mada4
Sri HandayaniIndonesian Institute of Sciences3
Nur Amalia ChoironiJenderal Soedirman University3
Sendy JunediAtma Jaya University Yogyakarta3
Sofa FaridaUniversitas Gadjah Mada3
Indri KusharyantiTanjungpura University3
Yonika Arum LarasatiUniversitas Gadjah Mada3
Raditya Prima IstiajiUniversitas Gadjah Mada3
Astrid Ayu MarutiUniversitas Gadjah Mada3
Muhammad Salman FarezaJenderal Soedirman University2
Masashi KawaichiNara Institute of Science and Technology2
Nunuk Aries NurulitaMuhammadiyah University Purwokerto2
Suwijiyo PramonoUniversitas Gadjah Mada2
Zalinar UdinIndonesian Institute of Sciences2
Yogi ErtantoUniversitas Gadjah Mada2
Aulia Nur SeptianiUniversitas Gadjah Mada2
Beni LestariUniversitas Gadjah Mada2
Asri Mega PutriUniversitas Gadjah Mada2
Hilyatul FadliyahUniversitas Gadjah Mada2

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Sumber metadata: OAI-PMH (metadata jurnal) https://ijcc.chemoprev.org/index.php/ijcc/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Combination of Solanum nigrum L. Herb Ethanolic Extract and Doxorubicin Performs Synergism on T47D Breast Cancer Cells</dc:title>
	<dc:creator>Anindyajati, Anindyajati</dc:creator>
	<dc:creator>Sarmoko, Sarmoko</dc:creator>
	<dc:creator>Putri, Dyaningtyas Dewi Pamungkas</dc:creator>
	<dc:creator>Hermawan, Adam</dc:creator>
	<dc:creator>Meiyanto, Edy</dc:creator>
	<dc:description xml:lang="en-US">Leunca (Solanum nigrum L.) has been proven to possess anticancer activity on some type of cancer cells. In vitro study of solamargine found in the herb showed cytotoxic effect against several breast cancer cell lines, such as T47D and MDA-MB-31. Hence, further study on its potential as a co-chemotherapeutic agent needs to be conducted, in order to overcome resistance problem commonly found in cancer chemotherapy. This study aimed to examine the cytotoxic activity of leunca herb ethanolic extract (LEE) alone and its combination with doxorubicin. Single and combinational treatment of LEE and doxorubicin on T47D breast cancer cells were done, and their viability representing cytotoxicity were analyzed by using MTT assay to determine the IC50 value and combination index (CI) to evaluate the combinational effect. Twenty four hours-treatment of LEE alone gave cytotoxicity activity showing a dose-dependent manner with the IC50 of 47 µg/ml, while combinational treatment showed that 4 µg/ml LEE was found to be synergist with 4 nM doxorubicin on T47D cells, with the optimum CI value of 0.59. This result shows that Solanum nigrum L. is potential to be proposed as doxorubicin co-chemotherapeutic agent against breast cancer. Further study on its molecular mechanism needs to be conducted.Key words: Solanum nigrum, doxorubicin, synergist, breast cancer</dc:description>
	<dc:publisher xml:lang="en-US">Indonesian Society for Cancer Chemoprevention</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2010-06-30</dc:date>
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	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ijcc.chemoprev.org/index.php/ijcc/article/view/14</dc:identifier>
	<dc:identifier>10.14499/indonesianjcanchemoprev1iss2pp78-84</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Cancer Chemoprevention; Vol 1, No 2 (2010); 78-84</dc:source>
	<dc:source>2355-8989</dc:source>
	<dc:source>2088-0197</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ijcc.chemoprev.org/index.php/ijcc/article/view/14/15</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2017 Indonesian Journal of Cancer Chemoprevention</dc:rights>
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