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in vitro Antidiabetic, Antioxidant and Cytotoxic Activities of Syzygium cumini Fractions from Leaves Ethanol Extract

Indonesian Journal of Cancer Chemoprevention · Vol. 10 No. 1 (2019) · hlm. 24–29

DOI
10.14499/indonesianjcanchemoprev10iss1pp24-29
ISSN
2355-8989, 2088-0197
Terbit
2019-02-28
Penerbit
Indonesian Society for Cancer Chemoprevention
Bahasa
eng

Abstrak

Ethanol extract of Syzygium cumini (jamblang) leaves reveal its significant α-glucosidase inhibitory activity which perform the potential activity of this plant extract as antidiabetic agent. However, other bioactivities of this plant extract have been reported. The aim of current study was to evaluate the comparison of in vitro antidiabetic, antioxidant and cytotoxic activity of S. cumini fractions. The S. cumini leaves ethanol extract was fractionated by using column chromatography with n-hexane, ethyl acetate and methanol as eluents. Seven fractions were obtained from column chromatography (F1-7). The results showed that the best antidiabetic activity was found in F5 (93% α-glucosidase inhibitory activity), the best antioxidant activity was found in F4 (83% inhibition of DPPH free radical) and the best cytotoxic activity was found in F2 (69% growth inhibition of T47D breast cancer cell line). Therefore besides in vitro antidiabetic activity, fractions of S. cumini leaves ethanol extract also showed antioxidant and cytotoxic activities. Since the results showed that the most active fractions for antidiabetic, antioxidant and cytotoxicity were differed, it could be possible to isolate the different potential active compounds for each activity.Keywords: Syzygium cumini, α-glucosidase inhibitor, DPPH, cytotoxicity

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  • Indonesian Institute of Sciences
  • National Research and Innovation Agency
  • Universitas Gadjah Mada
  • IPB University
  • Sumatera Institute of Technology
  • Universitas Bina Bangsa
  • University of Singaperbangsa Karawang
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Rekan penulisOrganisasiArtikel bersama
Riris Istighfari JenieUniversitas Gadjah Mada6
Ratna Asmah SusidartiUniversitas Gadjah Mada4
Muhammad HanafiNational Research and Innovation Agency4
Marissa AngelinaIndonesian Institute of Sciences4
Edy MeiyantoUniversitas Gadjah Mada3
Zalinar UdinIndonesian Institute of Sciences3
Sri HartatiIndonesian Institute of Sciences3
Puspa Dewi LotulungIndonesian Institute of Sciences3
Vera PermatasariNational Research and Innovation Agency2
Muhammad Eka PrastyaNational Research and Innovation Agency2
Erma SuryantiSumatera Institute of Technology2
Gian PrimahanaNational Research and Innovation Agency2
Dwi Ni’maturrohmahAfiliasi tidak diketahui1
Cici DarsihNational Research and Innovation Agency1
Marlyn Dian LaksitoriniUniversitas Gadjah Mada1
Hani SusantiNational Research and Innovation Agency1
Noor HidhayatiNational Research and Innovation Agency1
Anastasia Wheni IndrianingsihNational Research and Innovation Agency1
Rizal Maulana HasbyUniversitas Bina Bangsa1
Akhmad DarmawanIndonesian Institute of Sciences1
Dwi RetnowatiAfiliasi tidak diketahui1
Muhammad AsrilAfiliasi tidak diketahui1
Elisa Nurma RianaSumatera Institute of Technology1
Tjandrawati MozefIndonesian Institute of Sciences1
Indri YatiNational Research and Innovation Agency1
Irmanida BatubaraIPB University1
Novita ArianiNational Research and Innovation Agency1
Apriza YuswanUniversity of Singaperbangsa Karawang1
La Ode Abdul Fajar HasiduUniversitas Sembilanbelas November Kolaka1
Sumihartati SimbolonIPB University1
Rhesi KristianaIndonesian Coral Reef Foundation1
Jepri Agung PriyantoIPB University1

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Sumber metadata: OAI-PMH (metadata jurnal) https://ijcc.chemoprev.org/index.php/ijcc/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">in vitro Antidiabetic, Antioxidant and Cytotoxic Activities of Syzygium cumini Fractions from Leaves Ethanol Extract</dc:title>
	<dc:creator>Artanti, Nina</dc:creator>
	<dc:creator>Maryani, Faiza</dc:creator>
	<dc:creator>Dewi, Rizna Triana</dc:creator>
	<dc:creator>Handayani, Sri</dc:creator>
	<dc:creator>Dewijanti, Indah Dwiatmi</dc:creator>
	<dc:creator>Meilawati, Lia</dc:creator>
	<dc:creator>Filaila, Euis</dc:creator>
	<dc:creator>Udin, Linar Zalinar</dc:creator>
	<dc:description xml:lang="en-US">Ethanol extract of Syzygium cumini (jamblang) leaves reveal its significant α-glucosidase inhibitory activity which perform the potential activity of this plant extract as antidiabetic agent. However, other bioactivities of this plant extract have been reported. The aim of current study was to evaluate the comparison of in vitro antidiabetic, antioxidant and cytotoxic activity of S. cumini fractions. The S. cumini leaves ethanol extract was fractionated by using column chromatography with n-hexane, ethyl acetate and methanol as eluents. Seven fractions were obtained from column chromatography (F1-7). The results showed that the best antidiabetic activity was found in F5 (93% α-glucosidase inhibitory activity), the best antioxidant activity was found in F4 (83% inhibition of DPPH free radical) and the best cytotoxic activity was found in F2 (69% growth inhibition of T47D breast cancer cell line). Therefore besides in vitro antidiabetic activity, fractions of S. cumini leaves ethanol extract also showed antioxidant and cytotoxic activities. Since the results showed that the most active fractions for antidiabetic, antioxidant and cytotoxicity were differed, it could be possible to isolate the different potential active compounds for each activity.Keywords : Syzygium cumini, α-glucosidase inhibitor, DPPH, cytotoxicity</dc:description>
	<dc:publisher xml:lang="en-US">Indonesian Society for Cancer Chemoprevention</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2019-02-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US"></dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ijcc.chemoprev.org/index.php/ijcc/article/view/262</dc:identifier>
	<dc:identifier>10.14499/indonesianjcanchemoprev10iss1pp24-29</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Cancer Chemoprevention; Vol 10, No 1 (2019); 24-29</dc:source>
	<dc:source>2355-8989</dc:source>
	<dc:source>2088-0197</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ijcc.chemoprev.org/index.php/ijcc/article/view/262/178</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2019 Nina Artanti, Linar Zalinar Udin, Faiza Maryani, Rizna Triana Dewi, Sri Handayani, Indah Dwiatmi Dewijanti, Lia Meilawati, Euis Filaila</dc:rights>
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