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Synergistic Combination of Ciplukan (Physalis angulata) Herbs Ethanolic Extract and Doxorubicin on T47D Breast Cancer Cells

Indonesian Journal of Cancer Chemoprevention · Vol. 1 No. 1 (2010) · hlm. 26–31

DOI
10.14499/indonesianjcanchemoprev1iss1pp26-31
ISSN
2355-8989, 2088-0197
Terbit
2010-02-28
Penerbit
Indonesian Society for Cancer Chemoprevention
Bahasa
eng

Abstrak

Doxorubicin is one of chemotherapeutic agent widely used in breast cancer treatment, but in high dose doxorubicin gives negative side effect, including vomit, nausea, immune suppression, and cardiac toxicity. This toxicity hopefully could be reduced by combination chemotherapy using natural herbs such as ciplukan herb. This research was conducted to explore cytotoxic activity of single ciplukan herbs ethanolic extract and its combination with doxorubicin on T47D breast cancer cells. Cytotoxic activity of ciplukan herbs ethanolic extract only and its combination with doxorubicin were tested on T47D cells using MTT assay to obtain IC50 value and combination index (CI), respectively. Single extract showed cytotoxic activity on T47D cells with IC50 value of was 160 µg/ml. Thus, combination treatment from ciplukan herbs ethanolic extract and doxorubicin showed synergistic effect (CI<1,0). This effect was reached at concentration of ciplukan herbs ethanolic extract-doxorubicin 80 μg/ml- 2 nM, 80 μg/ml-4 nM, and 80 μg/ml-8 nM. This research indicated that ciplukan herbs ethanolic extract is potential to be applied as co-chemotherapeutic agent in breast cancer therapy.Key word: ciplukan herbs, doxorubicin, co-chemotherapy, T47D cells

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  • Universitas Gadjah Mada
  • Indonesian Institute of Sciences
  • National Research and Innovation Agency
  • Kementerian Kesehatan Republik Indonesia
  • Nara Institute of Science and Technology
  • Atma Jaya University Yogyakarta
  • Muhammadiyah University Purwokerto
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Rekan penulisOrganisasiArtikel bersama
Riris Istighfari JenieUniversitas Gadjah Mada24
Muthi IkawatiUniversitas Gadjah Mada15
Rohmad Yudi UtomoUniversitas Gadjah Mada13
Dyaningtyas Dewi Pamungkas PutriUniversitas Gadjah Mada9
Faaza Aulia RahmanUniversitas Gadjah Mada7
Sri HandayaniIndonesian Institute of Sciences7
Desty Restia RahmawatiUniversitas Gadjah Mada7
Larasati LarasatiUniversitas Gadjah Mada6
Sari HaryantiKementerian Kesehatan Republik Indonesia5
Dhania NovitasariUniversitas Gadjah Mada5
Anindyajati AnindyajatiUniversitas Gadjah Mada5
Indri KusharyantiTanjungpura University5
Yurista GilangUniversitas Gadjah Mada5
Retno MurwantiUniversitas Gadjah Mada4
Sendy JunediAtma Jaya University Yogyakarta4
Zalinar UdinIndonesian Institute of Sciences4
Lailatul QodriaUniversitas Gadjah Mada4
Gergorius Gena MaranUniversitas Gadjah Mada4
Ummi Maryam ZulfinUniversitas Gadjah Mada3
Erlina RivantiUniversitas Gadjah Mada3
Yogi ErtantoUniversitas Gadjah Mada3
Aulia Nur SeptianiUniversitas Gadjah Mada3
Herwandhani PutriUniversitas Gadjah Mada3
Nur Fitra SariUniversitas Gadjah Mada3
Yuni Fajar EstiUniversitas Gadjah Mada3
Masashi KawaichiNara Institute of Science and Technology2
Nunuk Aries NurulitaMuhammadiyah University Purwokerto2
Suwijiyo PramonoUniversitas Gadjah Mada2
Beni LestariUniversitas Gadjah Mada2
Asri Mega PutriUniversitas Gadjah Mada2
Hilyatul FadliyahUniversitas Gadjah Mada2
Yonika Arum LarasatiUniversitas Gadjah Mada2
Raisatun Nisa SugiyantoUniversitas Gadjah Mada2
Fatiha Citra EffendiUniversitas Gadjah Mada2

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Sumber metadata: OAI-PMH (metadata jurnal) https://ijcc.chemoprev.org/index.php/ijcc/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Synergistic Combination of Ciplukan (Physalis angulata) Herbs Ethanolic Extract and Doxorubicin on T47D Breast Cancer Cells</dc:title>
	<dc:creator>Armandari, Inna</dc:creator>
	<dc:creator>Palupi, Kartika Dyah</dc:creator>
	<dc:creator>Farida, Sofa</dc:creator>
	<dc:creator>Hermawan, Adam</dc:creator>
	<dc:creator>Susidarti, Ratna Asmah</dc:creator>
	<dc:creator>Meiyanto, Edy</dc:creator>
	<dc:description xml:lang="en-US">Doxorubicin is one of chemotherapeutic agent widely used in breast cancer treatment, but in high dose doxorubicin gives negative side effect, including vomit, nausea, immune suppression, and cardiac toxicity. This toxicity hopefully could be reduced by combination chemotherapy using natural herbs such as ciplukan herb. This research was conducted to explore cytotoxic activity of single ciplukan herbs ethanolic extract and its combination with doxorubicin on T47D breast cancer cells. Cytotoxic activity of ciplukan herbs ethanolic extract only and its combination with doxorubicin were tested on T47D cells using MTT assay to obtain IC50 value and combination index (CI), respectively. Single extract showed cytotoxic activity on T47D cells with IC50 value of was 160 µg/ml. Thus, combination treatment from ciplukan herbs ethanolic extract and doxorubicin showed synergistic effect (CI&lt;1,0). This effect was reached at concentration of ciplukan herbs ethanolic extract-doxorubicin 80 μg/ml- 2 nM, 80 μg/ml-4 nM, and 80 μg/ml-8 nM. This research indicated that ciplukan herbs ethanolic extract is potential to be applied as co-chemotherapeutic agent in breast cancer therapy.Key word : ciplukan herbs, doxorubicin, co-chemotherapy, T47D cells</dc:description>
	<dc:publisher xml:lang="en-US">Indonesian Society for Cancer Chemoprevention</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2010-02-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
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	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ijcc.chemoprev.org/index.php/ijcc/article/view/5</dc:identifier>
	<dc:identifier>10.14499/indonesianjcanchemoprev1iss1pp26-31</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Cancer Chemoprevention; Vol 1, No 1 (2010); 26-31</dc:source>
	<dc:source>2355-8989</dc:source>
	<dc:source>2088-0197</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ijcc.chemoprev.org/index.php/ijcc/article/view/5/6</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2017 Indonesian Journal of Cancer Chemoprevention</dc:rights>
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