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Trigona sp. Propolis Ethanolic Extract Decreased Chloramphenicol-induced Serum Glutamic Oxaloacetic Transaminase and Alkaline Phosphatase Levels of Rats (Rattus novergicus)

Indonesian Journal of Cancer Chemoprevention · Vol. 9 No. 3 (2018) · hlm. 110–117

DOI
10.14499/indonesianjcanchemoprev9iss3pp110-117
ISSN
2355-8989, 2088-0197
Terbit
2018-10-30
Penerbit
Indonesian Society for Cancer Chemoprevention
Bahasa
eng

Abstrak

Liver has an important role in detoxification of toxins such as xenobiotic which could interfere the function of liver. Chloramphenicol is an antibiotic widely used,despite of its toxicity potentials. The enhancement of free radicals in the body could suppress antioxidant activity. Propolis of Trigona sp. has been known to contain very high amount of antioxidants. The enhanced serum glutamic oxaloacetic transaminase (SGOT) and alkaline phosphatase (ALP) levels in serum is used as marker of liver damage due to the increase of free radicals. The purpose of this study was to observe the effect of Trigona sp. propolis ethanolic extract on SGOT and ALP levels in rats (Rattus novergicus) pretreated by chloramphenicol to induce liver damage. Test animals used for this research were male rats aged 8-12 weeks divided into five treatment groups: negative controlgroup (normal), positive control group (induced by 400 mg/kgBW chloramphenicol), first therapy group, second therapy group, third therapy group induced by chloramphenicol with and propolis extract with the dose of 8 mg, 16 mg, and 24 mg, respectively. Chloramphenicol was injected subcutaneously for 14 days, whereas propolis extract were administered orally for 21 days. The level of SGOT and ALP was determined using spectophotometry. The results showed that propolis extract could reduce levels of SGOT and ALP. Dose of 24 mg/kg was the effective dose to decrease levels of SGOT and ALP significantly (p<0.01). Hence, it may be concluded that the ethanol extract of propolis could be used as herbal therapy in rats model of liver damage.Keywords: ALP, liver, chloramphenicol, propolis, SGOT

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  • University of Brawijaya
  • Hasanuddin University
  • Universitas Esa Unggul
  • Universitas Gadjah Mada
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Rekan penulisOrganisasiArtikel bersama
Nursinah AmirHasanuddin University1
Wayan Tunas ArtamaUniversitas Gadjah Mada1
Sumartono SumartonoUniversitas Esa Unggul1
Viski Fitri HendrawanUniversity of Brawijaya1
Khoirus ViestariaUniversity of Brawijaya1
Handayu UntariUniversity of Brawijaya1
Padaga PadagaUniversity of Brawijaya1
Albiruni HaryoUniversity of Brawijaya1
Ivana Aginta Br GintingUniversity of Brawijaya1
Andreas Bandang HardianUniversity of Brawijaya1
Ani SetianingrumUniversity of Brawijaya1
Maulidi Robingi Mardiyani WukiraniUniversity of Brawijaya1
Essly Hervianingsih AdhaUniversity of Brawijaya1
Sang Ayu Putri Aristya DewiUniversity of Brawijaya1
Ajeng Erika Prihatuti HaskitoUniversity of Brawijaya1
Faniar Tasha AlmaraUniversity of Brawijaya1
Restu Wika BinaUniversity of Brawijaya1

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Sumber metadata: OAI-PMH (metadata jurnal) https://ijcc.chemoprev.org/index.php/ijcc/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Trigona sp. Propolis Ethanolic Extract Decreased Chloramphenicol-induced Serum Glutamic Oxaloacetic Transaminase and Alkaline Phosphatase Levels of Rats (Rattus novergicus)</dc:title>
	<dc:creator>Mahdi, Chanif</dc:creator>
	<dc:creator>Zukiaturrahmah, Anna</dc:creator>
	<dc:creator>Pratama, Dyah Ayu Oktavianie Ardhiana</dc:creator>
	<dc:creator>Nugraheni, Putranty Widha</dc:creator>
	<dc:description xml:lang="en-US">Liver has an important role in detoxification of toxins such as xenobiotic which could interfere the function of liver. Chloramphenicol is an antibiotic widely used,despite of its toxicity potentials. The enhancement of free radicals in the body could suppress antioxidant activity. Propolis of Trigona sp. has been known to contain very high amount of antioxidants. The enhanced serum glutamic oxaloacetic transaminase (SGOT) and alkaline phosphatase (ALP) levels in serum is used as marker of liver damage due to the increase of free radicals. The purpose of this study was to observe the effect of Trigona sp. propolis ethanolic extract on SGOT and ALP levels in rats (Rattus novergicus) pretreated by chloramphenicol to induce liver damage. Test animals used for this research were male rats aged 8-12 weeks divided into five treatment groups: negative controlgroup (normal), positive control group (induced by 400 mg/kgBW chloramphenicol), first therapy group, second therapy group, third therapy group induced by chloramphenicol with and propolis extract with the dose of 8 mg, 16 mg, and 24 mg, respectively. Chloramphenicol was injected subcutaneously for 14 days, whereas propolis extract were administered orally for 21 days. The level of SGOT and ALP was determined using spectophotometry. The results showed that propolis extract could reduce levels of SGOT and ALP. Dose of 24 mg/kg was the effective dose to decrease levels of SGOT and ALP significantly (p&lt;0.01). Hence, it may be concluded that the ethanol extract of propolis could be used as herbal therapy in rats model of liver damage.Keywords : ALP, liver, chloramphenicol, propolis, SGOT</dc:description>
	<dc:publisher xml:lang="en-US">Indonesian Society for Cancer Chemoprevention</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2018-10-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US"></dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ijcc.chemoprev.org/index.php/ijcc/article/view/216</dc:identifier>
	<dc:identifier>10.14499/indonesianjcanchemoprev9iss3pp110-117</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Cancer Chemoprevention; Vol 9, No 3 (2018); 110-117</dc:source>
	<dc:source>2355-8989</dc:source>
	<dc:source>2088-0197</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ijcc.chemoprev.org/index.php/ijcc/article/view/216/167</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2018 Chanif Mahdi, Anna Zukiaturrahmah, Dyah Ayu Oktavianie A. Pratama</dc:rights>
</oai_dc:dc>