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Analysis of the Histopathology, TNF-α of Microglia Cells Expression, NRG-1/erbB Oligodendrocyte, and Ki67/Apoptosis of Dentate Gyrus Rattus novergicus Brain After Acute Traumatic Brain Injury

Indonesian Journal of Cancer Chemoprevention · Vol. 6 No. 1 (2015) · hlm. 20–29

DOI
10.14499/indonesianjcanchemoprev6iss1pp20-29
ISSN
2355-8989, 2088-0197
Terbit
2015-02-28
Penerbit
Indonesian Society for Cancer Chemoprevention
Bahasa
eng

Abstrak

Head trauma or traumatic brain injury (TBI) gives most serious impact on the central nervous system. Several experimental models have been established to mimic different pathogenesis characteristics of TBI. The purpose of this study was to determine whether there is evidence of hystopathological lesions in the brain tissue after Marmorou TBI models. This study uses Rattus norvegicus Sprague Dawley strain. Macroscopic and microscopic observations on the brain tissue were done. Macroscopic lesions were observed in the brain. Microscopic observation was performed with Haematoxylin-Eosin (HE) staining and immunohistochemistry on the distribution of microglia cells and pyramidal cells in the cortex. Meanwhile, the distribution of NRG-1/ErbB, proliferation, and apoptosis were observed in the hippocampus. The results of macroscopic observation showed that there were wounds caused by falling loads and vasodilatation. On microscopic observation, the TBI group showed an increase in neutrophils distribution and distribution of activated microglia to produce TNF-α, and decrease in the number of cortical pyramidal cells significantly. The distribution of NRG-1 tended to decrease after exposure of TBI and had no effect on its receptor, erbB. Exposure of TBI appears to lower the activity of neuronal cells proliferation in dentate gyrus (DG) area and significantly increase the number of apoptotic cells. Marmarou model is a physiological model of TBI that spontaneously occurs following a trauma to the head, for example trauma due to an accident. This data can be used as a preliminary data of inflammation and tissue regeneration of disrupted adult brain. Therefore, this research could be used as the basis in the studies of therapeutic agents in the process of neurogenesis of brain cells.Keywords: traumatic brain injury, ERG-1/ErbB, dentate gyrus, Ki67, TNF-a, microglia

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  • University of Brawijaya
  • Padjadjaran University
  • RSUD Prof. Dr. Saiful Anwar Malang
  • Ministry of Agriculture
  • UIN Sunan Ampel Surabaya
  • Universitas Jenderal Achmad Yani
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Rekan penulisOrganisasiArtikel bersama
Erlin Aditia PurmitasariUniversity of Brawijaya4
Lilin Andreas VitaniaUniversity of Brawijaya4
Fifi Farida FajrinUniversity of Brawijaya1
Christopher Kuncoro JohanUniversity of Brawijaya1
Liziyyannida LiziyyannidaUniversity of Brawijaya1
Vitriana BibenPadjadjaran University1
Novitri SumardiPadjadjaran University1
Arya WijayaAfiliasi tidak diketahui1
Septania Elfira SimatupangAfiliasi tidak diketahui1
Nur SamsuRSUD Prof. Dr. Saiful Anwar Malang1
Diana LyrawatiUniversity of Brawijaya1
Natasya Adiba ZahrahUniversity of Brawijaya1
Sri WidyartiUniversity of Brawijaya1
A Aulanni’amUniversity of Brawijaya1
Sutiman Bambang SumitroUniversity of Brawijaya1
Olly IndrajaniAfiliasi tidak diketahui1
Dyah Kinasih WuragilUniversity of Brawijaya1
Dodik PrasetyoMinistry of Agriculture1
Syifa MustikaUniversity of Brawijaya1
Aditya Tri HernowoAfiliasi tidak diketahui1
Ahmad LubabUIN Sunan Ampel Surabaya1
Kusworini HandonoUniversity of Brawijaya1
Lilik IndahwatiUniversity of Brawijaya1
Linda Ratna WatiUniversity of Brawijaya1
Inmas Andi SermoatiUniversitas Jenderal Achmad Yani1

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Sumber metadata: OAI-PMH (metadata jurnal) https://ijcc.chemoprev.org/index.php/ijcc/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Analysis of the Histopathology, TNF-α of Microglia Cells Expression, NRG-1/erbB Oligodendrocyte, and Ki67/Apoptosis of Dentate Gyrus Rattus novergicus Brain After Acute Traumatic Brain Injury</dc:title>
	<dc:creator>Riawan, Wibi</dc:creator>
	<dc:creator>Alfiantya, Putri Fitri</dc:creator>
	<dc:creator>Adianingsih, Oktavia Rahayu</dc:creator>
	<dc:creator>Zulkarnaen, Zulkarnaen</dc:creator>
	<dc:creator>Jazmi, Alif Fariz</dc:creator>
	<dc:creator>Hemas N., Sitti Ayu</dc:creator>
	<dc:description xml:lang="en-US">Head trauma or traumatic brain injury (TBI) gives most serious impact on the central nervous system. Several experimental models have been established to mimic different pathogenesis characteristics of TBI. The purpose of this study was to determine whether there is evidence of hystopathological lesions in the brain tissue after Marmorou TBI models. This study uses Rattus norvegicus Sprague Dawley strain. Macroscopic and microscopic observations on the brain tissue were done. Macroscopic lesions were observed in the brain. Microscopic observation was performed with Haematoxylin-Eosin (HE) staining and immunohistochemistry on the distribution of microglia cells and pyramidal cells in the cortex. Meanwhile, the distribution of NRG-1/ErbB, proliferation, and apoptosis were observed in the hippocampus. The results of macroscopic observation showed that there were wounds caused by falling loads and vasodilatation. On microscopic observation, the TBI group showed an increase in neutrophils distribution and distribution of activated microglia to produce TNF-α, and decrease in the number of cortical pyramidal cells significantly. The distribution of NRG-1 tended to decrease after exposure of TBI and had no effect on its receptor, erbB. Exposure of TBI appears to lower the activity of neuronal cells proliferation in dentate gyrus (DG) area and significantly increase the number of apoptotic cells. Marmarou model is a physiological model of TBI that spontaneously occurs following a trauma to the head, for example trauma due to an accident. This data can be used as a preliminary data of inflammation and tissue regeneration of disrupted adult brain. Therefore, this research could be used as the basis in the studies of therapeutic agents in the process of neurogenesis of brain cells.Keywords: traumatic brain injury, ERG-1/ErbB, dentate gyrus, Ki67, TNF-a, microglia</dc:description>
	<dc:publisher xml:lang="en-US">Indonesian Society for Cancer Chemoprevention</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2015-02-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US"></dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ijcc.chemoprev.org/index.php/ijcc/article/view/80</dc:identifier>
	<dc:identifier>10.14499/indonesianjcanchemoprev6iss1pp20-29</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Cancer Chemoprevention; Vol 6, No 1 (2015); 20-29</dc:source>
	<dc:source>2355-8989</dc:source>
	<dc:source>2088-0197</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ijcc.chemoprev.org/index.php/ijcc/article/view/80/80</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2017 Indonesian Journal of Cancer Chemoprevention</dc:rights>
</oai_dc:dc>