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Antiproliferative Effect of Chloroform Extract of Cangkring Leaves (Erythrina fusca Lour.) and Its Isolates against HeLa Cells

Indonesian Journal of Cancer Chemoprevention · Vol. 3 No. 1 (2012) · hlm. 358–363

DOI
10.14499/indonesianjcanchemoprev3iss1pp358-363
ISSN
2355-8989, 2088-0197
Terbit
2012-02-28
Penerbit
Indonesian Society for Cancer Chemoprevention
Bahasa
eng

Abstrak

Cervical cancer is a type of cancer possessing the 3rd highest incidence among women worldwide. Today’s therapies against cancer are still ineffective, thus people are seeking for alternative method. Erythrina fusca Lour. has been used traditionally as anticancer. This experiment is conducted to study the ability of chloroform extract of E. fusca Lour. leaves and its isolates on HeLa cervical cancer cells. The cytotoxicity assay and doubling time assay were done using direct counting method, while the DNA staining assay was done using acrydine orange. The chloroform extract and isolate # 30 showed cytotoxic activity with IC50 of 16 and 5 µg/ml, respectively, while isolate # 2 and isolate # 8 didn’t. The effluent # 30 could not affect HeLa cells growth at the given concentration, but it might promote DNA fragmentation indicating apoptosis induction. The molecular mechanisms underlying these effects still need to be further explored.Keywords: Erythrina fusca Lour., isolate and effluent of chloroform extract, antiproliferative, cervical cancer

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  • Universitas Jember
  • Universitas Gadjah Mada
  • Muhammadiyah University Purwokerto
  • Muhammadiyah University of Yogyakarta
  • Rumah Sakit Umum Pusat Dr. Sardjito
  • Universitas Airlangga
  • National Research and Innovation Agency
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Rekan penulisOrganisasiArtikel bersama
Banun KusumawardaniUniversitas Jember2
Nunuk Aries NurulitaMuhammadiyah University Purwokerto2
Dwi Merry Christmarini RobinUniversitas Gadjah Mada1
Irma Josefina SavitriUniversitas Airlangga1
Dea Ajeng Pravita SuendiUniversitas Jember1
Subagus WahyuonoUniversitas Gadjah Mada1
Yuli WidiyastutiNational Research and Innovation Agency1
Rarastoeti PratiwiUniversitas Gadjah Mada1
Rifki FebriansahMuhammadiyah University of Yogyakarta1
Dyaningtyas Dewi Pamungkas PutriUniversitas Gadjah Mada1
Sarmoko SarmokoSumatera Institute of Technology1
Nur IsmiyatiPoliteknik Kesehatan Bhakti Setya Indonesia1
Aditya FitriasariUniversitas Gadjah Mada1
Novyananda SalmasfattahMuhammadiyah University Purwokerto1
Nuri NuriUniversitas Jember1
Indah Yulia NingsihUniversitas Jember1
Bawon TriatmokoUniversitas Jember1
Dewi DianasariUniversitas Jember1
Fitriyani FitriyaniUniversitas Halu Oleo1
Ari Satia NugrahaUniversitas Jember1
Qonita Nafilah FebiUniversitas Jember1
Malihatul RosidahUniversitas Jember1
Deri Abdul AzisUniversitas Jember1
Agung Endro NugrohoUniversitas Gadjah Mada1
Puguh NoviarsitoMuhammadiyah University of Yogyakarta1

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Sumber metadata: OAI-PMH (metadata jurnal) https://ijcc.chemoprev.org/index.php/ijcc/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Antiproliferative Effect of Chloroform Extract of Cangkring Leaves (Erythrina fusca Lour.) and Its Isolates against HeLa Cells</dc:title>
	<dc:creator>Puspitasari, Endah</dc:creator>
	<dc:creator>Setyowati, Endah Dwi</dc:creator>
	<dc:creator>Dhiani, Binar Asrining</dc:creator>
	<dc:creator>Riyanto, Sugeng</dc:creator>
	<dc:description xml:lang="en-US">Cervical cancer is a type of cancer possessing the 3rd highest incidence among women worldwide. Today’s therapies against cancer are still ineffective, thus people are seeking for alternative method. Erythrina fusca Lour. has been used traditionally as anticancer. This experiment is conducted to study the ability of chloroform extract of E. fusca Lour. leaves and its isolates on HeLa cervical cancer cells. The cytotoxicity assay and doubling time assay were done using direct counting method, while the DNA staining assay was done using acrydine orange. The chloroform extract and isolate # 30 showed cytotoxic activity with IC50 of 16 and 5 µg/ml, respectively, while isolate # 2 and isolate # 8 didn’t. The effluent # 30 could not affect HeLa cells growth at the given concentration, but it might promote DNA fragmentation indicating apoptosis induction. The molecular mechanisms underlying these effects still need to be further explored.Keywords: Erythrina fusca Lour., isolate and effluent of chloroform extract, antiproliferative, cervical cancer</dc:description>
	<dc:publisher xml:lang="en-US">Indonesian Society for Cancer Chemoprevention</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2012-02-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US"></dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ijcc.chemoprev.org/index.php/ijcc/article/view/56</dc:identifier>
	<dc:identifier>10.14499/indonesianjcanchemoprev3iss1pp358-363</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Cancer Chemoprevention; Vol 3, No 1 (2012); 358-363</dc:source>
	<dc:source>2355-8989</dc:source>
	<dc:source>2088-0197</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ijcc.chemoprev.org/index.php/ijcc/article/view/56/57</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2017 Indonesian Journal of Cancer Chemoprevention</dc:rights>
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