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Evaluation of the Potential In Vitro effects of Plantago major L. on Wound Healing in Human Umbilical Vein Endothelial Cells (HUVEC)

Indonesian Journal of Cancer Chemoprevention · Vol. 15 No. 2 (2024) · hlm. 87–95

DOI
10.14499/indonesianjcanchemoprev15iss2pp87-95
ISSN
2355-8989, 2088-0197
Terbit
2024-06-30
Penerbit
Indonesian Society for Cancer Chemoprevention
Bahasa
eng

Abstrak

The treatment of skin wounds remains a major concern in the field of medicine, particularly in the case of chronic wounds resulting from various disorders such as diabetes. The utilization of herbs or herbal preparations for the purpose of healing skin wounds presents a therapeutic challenge within the realm of traditional medicine. Plantago major L. is known to have bioactive compounds that have wound healing activity such as aucubin. This study aimed to determine the in vitro wound healing potential of Plantago major L. extract (PLE). The study involved several assays, including phytochemical examination of PLE using TLC, cell viability testing using MTT assay, and wound healing testing using scratch assay on human umbilical vein endothelial cells (HUVEC). The results confirmed the presence of aucubin as one of the compounds in PLE. It was observed that PLE with 125 μg/mL exhibited the highest wound closure percentage at 90.66%. This study shows that PLE possesses wound healing capabilities.Keywords: Plantago major L., PLE, cytotoxic assay, wound scratch assay, HUVEC.

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  • Universitas Gadjah Mada
  • Universitas Jenderal Achmad Yani
  • Kementerian Kesehatan Republik Indonesia
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Rekan penulisOrganisasiArtikel bersama
Edy MeiyantoUniversitas Gadjah Mada4
Sari HaryantiKementerian Kesehatan Republik Indonesia2
Suwijiyo PramonoUniversitas Gadjah Mada2
Asri Mega PutriUniversitas Gadjah Mada2
Nindya Budiana PutriUniversitas Gadjah Mada2
- MustofaAfiliasi tidak diketahui1
Rachel TuralelyUniversitas Gadjah Mada1
Mahardika Agus WijayantiUniversitas Gadjah Mada1
Yoce ApriantoUniversitas Gadjah Mada1
Hilyatul FadliyahUniversitas Gadjah Mada1
Nindi WulandariUniversitas Gadjah Mada1
Fikriansyah FikriansyahUniversitas Gadjah Mada1
Mentari WidiastutiUniversitas Gadjah Mada1
Prisnu TirtanirmalaUniversitas Gadjah Mada1
Alifia Brilliani HidayahUniversitas Gadjah Mada1
Nuqya AshfannadaUniversitas Gadjah Mada1
Aisyah Nur KhasanahUniversitas Gadjah Mada1
Siti Nur AnnisaUniversitas Gadjah Mada1
Ghea Rachella TiffanyUniversitas Gadjah Mada1
Rahmawaty RachmadyUniversitas Gadjah Mada1
Idlohatud DilalahUniversitas Gadjah Mada1
Herwandhani PutriUniversitas Gadjah Mada1
Gagas Pradani Nur IlmawatiUniversitas Gadjah Mada1
Rohmad Yudi UtomoUniversitas Gadjah Mada1
Bani Adlina ShabrinaUniversitas Gadjah Mada1
Juang JuansaUniversitas Gadjah Mada1
Dhania NovitasariUniversitas Gadjah Mada1
Devyanto Hadi TriutomoUniversitas Gadjah Mada1
Fitriana Hayyu ArifahUniversitas Gadjah Mada1
Anselma IvanawatiUniversitas Gadjah Mada1
Zahrotul UlumUniversitas Gadjah Mada1
Layung Sekar Sih WikanthiUniversitas Gadjah Mada1
Lodyta Nawang TikaUniversitas Gadjah Mada1
Shofa AnnurUniversitas Gadjah Mada1
Sylvia Utami Tunjung PratiwiUniversitas Gadjah Mada1
Iramie Duma Kencana IriantoUniversitas Gadjah Mada1

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Sumber metadata: OAI-PMH (metadata jurnal) https://ijcc.chemoprev.org/index.php/ijcc/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Evaluation of the Potential In Vitro effects of Plantago major L.  on Wound Healing in Human Umbilical Vein Endothelial Cells (HUVEC)</dc:title>
	<dc:creator>Amalia, Latifa</dc:creator>
	<dc:creator>Murwanti, Retno</dc:creator>
	<dc:creator>Hertiani, Triana</dc:creator>
	<dc:creator>Purnomo, Kurnia Rahayu</dc:creator>
	<dc:description xml:lang="en-US"> The treatment of skin wounds remains a major concern in the field of medicine, particularly in the case of chronic wounds resulting from various disorders such as diabetes. The utilization of herbs or herbal preparations for the purpose of healing skin wounds presents a therapeutic challenge within the realm of traditional medicine. Plantago major L. is known to have bioactive compounds that have wound healing activity such as aucubin. This study aimed to determine the in vitro wound healing potential of Plantago major L. extract (PLE). The study involved several assays, including phytochemical examination of PLE using TLC, cell viability testing using MTT assay, and wound healing testing using scratch assay on human umbilical vein endothelial cells (HUVEC). The results confirmed the presence of aucubin as one of the compounds in PLE. It was observed that PLE with 125 μg/mL exhibited the highest wound closure percentage at 90.66%. This study shows that PLE possesses wound healing capabilities.Keywords: Plantago major L., PLE, cytotoxic assay, wound scratch assay, HUVEC.</dc:description>
	<dc:publisher xml:lang="en-US">Indonesian Society for Cancer Chemoprevention</dc:publisher>
	<dc:contributor xml:lang="en-US">national research and innovation agency (BRIN), Republic of Indonesia</dc:contributor>
	<dc:date>2024-06-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US"></dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ijcc.chemoprev.org/index.php/ijcc/article/view/500</dc:identifier>
	<dc:identifier>10.14499/indonesianjcanchemoprev15iss2pp87-95</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Cancer Chemoprevention; Vol 15, No 2 (2024); 87-95</dc:source>
	<dc:source>2355-8989</dc:source>
	<dc:source>2088-0197</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ijcc.chemoprev.org/index.php/ijcc/article/view/500/303</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2024 Indonesian Journal of Cancer Chemoprevention</dc:rights>
</oai_dc:dc>