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Growth of NIH 3T3 Fibroblast Cells Exposed to Carbonated Hydroxyapatite with Incorporated Propolis

Indonesian Journal of Cancer Chemoprevention · Vol. 11 No. 2 (2020) · hlm. 54–59

DOI
10.14499/indonesianjcanchemoprev11iss2pp54-59
ISSN
2355-8989, 2088-0197
Terbit
2020-06-30
Penerbit
Indonesian Society for Cancer Chemoprevention
Bahasa
eng

Abstrak

Carbonated hydroxyapatite is frequently used as bone graft material in dentistry. It is highly biocompatible, has osteoconductive properties, and functions as a drug delivery system. Propolis is a natural product from bees that has antibacterial and anti-inflammatory effects and is capable of accelerating wound healing. Incorporating propolis into carbonated hydroxyapatite was expected to enhance the wound-healing process by stimulating fibroblast growth and regenerating alveolar bone in the treatment of periodontitis. The aim of this study was to evaluate the effect of carbonated hydroxyapatite with incorporated propolis on the viability of NIH 3T3 fibroblast cells. This study used three treatment groups [carbonated hydroxyapatite with various concentrations of incorporated propolis (5%, 7.5%, and 10%)] and one control group (carbonated hydroxyapatite with no propolis). An MTT assay was carried out to assess cell viability, and absorbance readings were performed by using an ELISA reader. The data were analyzed by using one-way ANOVA. The results showed significant differences between all groups, and carbonated hydroxyapatite with 10% incorporated propolis has the highest cell viability level of all groups, while the control group has the lowest cell viability. In conclusion, adding propolis to carbonated hydroxyapatite could increase the growth of NIH 3T3 fibroblast cells. Keywords: Carbonated hydroxyapatite, Propolis, NIH 3T3 fibroblast cells, MTT assay

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33 penulis · 66 tautan kepenulisan bersama · 10 lintas organisasi

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  • Diponegoro University
  • Universitas Gadjah Mada
  • Universitas Jambi
  • Tropical Biosphere Research Center, University of the Ryukyus
  • Sriwijaya University
  • State University of Semarang
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Rekan penulisOrganisasiArtikel bersama
Jaya Putra JahidinUniversitas Jambi2
Nur Taufiq Samsudin PJAfiliasi tidak diketahui1
Diah Permata WijayantiDiponegoro University1
Handung NuryadiTropical Biosphere Research Center, University of the Ryukyus1
Ibnu PratiktoDiponegoro University1
Adi Priyo WicaksonoAfiliasi tidak diketahui1
Gita Surya YuningtyastutiAfiliasi tidak diketahui1
Ainun JariyahSriwijaya University1
Karyadi KaryadiAfiliasi tidak diketahui1
Eko SupraptonoAfiliasi tidak diketahui1
Ana Qurrota A'yunAfiliasi tidak diketahui1
Sri SukamtaState University of Semarang1
Siti Su'indayahAfiliasi tidak diketahui1
Yossi Norma ArbiyantiAfiliasi tidak diketahui1
Noferdiman NoferdimanUniversitas Jambi1
Olfa MegaUniversitas Jambi1
Sudadi SudadiAfiliasi tidak diketahui1
Ahmad SyaifyUniversitas Gadjah Mada1
Yoeliani BudisidhartaUniversitas Gadjah Mada1
Riawati UtamaAfiliasi tidak diketahui1
Pipin ArdhiantoAfiliasi tidak diketahui1
Muhammad Rijal Fahrudin HidayatAfiliasi tidak diketahui1
Muhammad Irsyad AmienAfiliasi tidak diketahui1
Achmad Ilham TohariAfiliasi tidak diketahui1
Hazbina Fauqi RamadhanAfiliasi tidak diketahui1
Muhammad ZainuriDiponegoro University1
Chrisna Adhi SuryonoDiponegoro University1
Hadi EndrawatiDiponegoro University1
Ervia YudiatiDiponegoro University1
Sri SedjatiDiponegoro University1

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Sumber metadata: OAI-PMH (metadata jurnal) https://ijcc.chemoprev.org/index.php/ijcc/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Growth of NIH 3T3 Fibroblast Cells Exposed to Carbonated Hydroxyapatite with Incorporated Propolis</dc:title>
	<dc:creator>Wijayanti, Puspaneka</dc:creator>
	<dc:creator>Lastianny, Sri Pramestri</dc:creator>
	<dc:creator>Suryono, Suryono</dc:creator>
	<dc:description xml:lang="en-US">Carbonated hydroxyapatite is frequently used as bone graft material in dentistry. It is highly biocompatible, has osteoconductive properties, and functions as a drug delivery system. Propolis is a natural product from bees that has antibacterial and anti-inflammatory effects and is capable of accelerating wound healing. Incorporating propolis into carbonated hydroxyapatite was expected to enhance the wound-healing process by stimulating fibroblast growth and regenerating alveolar bone in the treatment of periodontitis. The aim of this study was to evaluate the effect of carbonated hydroxyapatite with incorporated propolis on the viability of NIH 3T3 fibroblast cells. This study used three treatment groups [carbonated hydroxyapatite with various concentrations of incorporated propolis (5%, 7.5%, and 10%)] and one control group (carbonated hydroxyapatite with no propolis). An MTT assay was carried out to assess cell viability, and absorbance readings were performed by using an ELISA reader. The data were analyzed by using one-way ANOVA. The results showed significant differences between all groups, and carbonated hydroxyapatite with 10% incorporated propolis has the highest cell viability level of all groups, while the control group has the lowest cell viability. In conclusion, adding propolis to carbonated hydroxyapatite could increase the growth of NIH 3T3 fibroblast cells. Keywords: Carbonated hydroxyapatite, Propolis, NIH 3T3 fibroblast cells, MTT assay</dc:description>
	<dc:publisher xml:lang="en-US">Indonesian Society for Cancer Chemoprevention</dc:publisher>
	<dc:contributor xml:lang="en-US">Acknowledgment  This study was supported by grant Hibah Penelitian Dana Masyarakat Berbasis Luaran (Outcome Based) Faculty of Dentistry Gadjah Mada University, Republic of Indonesia, in the fiscal year 2019 under contract No. 4349/UN1/FKG1/Set.KG1/PT/2019</dc:contributor>
	<dc:date>2020-06-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US"></dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ijcc.chemoprev.org/index.php/ijcc/article/view/309</dc:identifier>
	<dc:identifier>10.14499/indonesianjcanchemoprev11iss2pp54-59</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Cancer Chemoprevention; Vol 11, No 2 (2020); 54-59</dc:source>
	<dc:source>2355-8989</dc:source>
	<dc:source>2088-0197</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ijcc.chemoprev.org/index.php/ijcc/article/view/309/213</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2020 Indonesian Journal of Cancer Chemoprevention</dc:rights>
</oai_dc:dc>