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Combination of Curcuma (Curcuma xanthorriza Roxb) Rhizome Ethanolic Extract and Awar-Awar (Ficus septica Burm.F) Leaves Ethanolic Extract Increases Cisplatin Cytotoxicity on T47D Breast Cancer Cells through Cell Cycle Modulation

Indonesian Journal of Cancer Chemoprevention · Vol. 8 No. 3 (2017) · hlm. 120–125

DOI
10.14499/indonesianjcanchemoprev8iss3pp120-125
ISSN
2355-8989, 2088-0197
Terbit
2017-10-31
Penerbit
Indonesian Society for Cancer Chemoprevention
Bahasa
eng

Abstrak

Curcuma (Curcuma xanthorriza Roxb.) and Awar-awar ((Ficus septica Burm.f.) are well known to have anticancer potential especially for breast cancer with low toxicity. This study aims to examine the potential effect of the combination of Curcuma ethanolic extracts (CEE) and awar-awar leaves ethanolic extract (AEE) to increase the efficacy of cisplatin toward T47D breast cancer cells. The combination activity was done using 3 series of concentration, 1/3; 1/6 and 1/12 of IC50, to determine the combination index (CI) of cisplatin, CEE and AEE under MTT assay. The result showed that the combination of 2.5 µM, 5 µg/ml, 1 µg/ml concentrations of cisplatin, CEE and AEE respectively result in synergistic effect with CI values less than 1. The treatment exhibited the cell accumulation in S phase (27.7%) against T47D breast cancer cells confirmed through cell cycle examination by flow cytometry. These results provided the evidence that the CEE and the AEE can be developed as co-chemotherapeutic agents combined with cisplatin to improve the effectiveness of breast cancer treatment.Keywords: Curcuma xanthorriza Roxb., Ficus septica Burm.f., cisplatin, cell cycle

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Ratna Asmah SusidartiAfiliasi tidak diketahui23
Adam HermawanAfiliasi tidak diketahui20
Muthi’ IkawatiAfiliasi tidak diketahui13
Rohmad Yudi UtomoAfiliasi tidak diketahui13
Sri HandayaniUniversity of Brawijaya9
Dyaningtyas Dewi Pamungkas PutriAfiliasi tidak diketahui7
Dhania NovitasariAfiliasi tidak diketahui6
Sari HaryantiAfiliasi tidak diketahui5
Retno MurwantiAfiliasi tidak diketahui4
Faaza Aulia RahmanAfiliasi tidak diketahui4
Desty Restia RahmawatiAfiliasi tidak diketahui4
Ummi Maryam ZulfinAfiliasi tidak diketahui4
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Zalinar UdinAfiliasi tidak diketahui4
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Hilyatul FadliyahAfiliasi tidak diketahui4
Rumiyati RumiyatiAfiliasi tidak diketahui4
Anindyajati AnindyajatiAfiliasi tidak diketahui3
Larasati LarasatiIPB University3
Erlina RivantiAfiliasi tidak diketahui3
Gergorius Gena MaranAfiliasi tidak diketahui3
Laili Nailul MunaAfiliasi tidak diketahui3
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Lailatul QodriaAfiliasi tidak diketahui2
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Asri Mega PutriAfiliasi tidak diketahui2
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Yonika Arum LarasatiAfiliasi tidak diketahui2
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Sumber metadata: OAI-PMH (metadata jurnal) https://ijcc.chemoprev.org/index.php/ijcc/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Combination of Curcuma (Curcuma xanthorriza Roxb) Rhizome Ethanolic Extract and Awar-Awar (Ficus septica Burm.F) Leaves Ethanolic Extract Increases Cisplatin Cytotoxicity on T47D Breast Cancer Cells through Cell Cycle Modulation</dc:title>
	<dc:creator>Hidayati, Devi Nisa</dc:creator>
	<dc:creator>Jenie, Riris Istighfari</dc:creator>
	<dc:creator>Meiyanto, Edy</dc:creator>
	<dc:description xml:lang="en-US">Curcuma (Curcuma xanthorriza Roxb.) and Awar-awar ((Ficus septica Burm.f.) are well known to have anticancer potential especially for breast cancer with low toxicity. This study aims to examine the potential effect of the combination of Curcuma ethanolic extracts (CEE) and awar-awar leaves ethanolic extract (AEE) to increase the efficacy of cisplatin toward T47D breast cancer cells. The combination activity was done using 3 series of concentration, 1/3; 1/6 and 1/12 of IC50, to determine the combination index (CI) of cisplatin, CEE and AEE under MTT assay. The result showed that the combination of 2.5 µM, 5 µg/ml, 1 µg/ml concentrations of  cisplatin, CEE and AEE respectively result in synergistic effect with CI values less than 1. The treatment exhibited the cell accumulation in S phase (27.7%) against T47D breast cancer cells confirmed through cell cycle examination by flow cytometry. These results provided the evidence that the CEE and the AEE can be developed as co-chemotherapeutic agents combined with cisplatin to improve the effectiveness of breast cancer treatment.Keywords : Curcuma xanthorriza Roxb., Ficus septica Burm.f., cisplatin, cell cycle</dc:description>
	<dc:publisher xml:lang="en-US">Indonesian Society for Cancer Chemoprevention</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2017-10-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
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	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ijcc.chemoprev.org/index.php/ijcc/article/view/186</dc:identifier>
	<dc:identifier>10.14499/indonesianjcanchemoprev8iss3pp120-125</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Cancer Chemoprevention; Vol 8, No 3 (2017); 120-125</dc:source>
	<dc:source>2355-8989</dc:source>
	<dc:source>2088-0197</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ijcc.chemoprev.org/index.php/ijcc/article/view/186/149</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2018 Indonesian Journal of Cancer Chemoprevention</dc:rights>
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