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Methanolic Extract of Red Betel Leaves (Piper crocatum Ruiz & Pav) Perform Cytotoxic Effect and Antimigration Activity toward Metastatic Breast Cancer

Indonesian Journal of Cancer Chemoprevention · Vol. 8 No. 3 (2017) · hlm. 94–100

DOI
10.14499/indonesianjcanchemoprev8iss3pp94-100
ISSN
2355-8989, 2088-0197
Terbit
2017-10-31
Penerbit
Indonesian Society for Cancer Chemoprevention
Bahasa
eng

Abstrak

Breast cancer is one type of cancer with a high mortality rate due to its metastatic property. Red betel leaves (Piper crocatum Ruiz and Pav) has been known as herbal medicine containing biophenolic, such as apigenin and luteolin derivatives which has cytotoxic activity toward cancer cells. This study is intended to explore the inhibitory effect of Piper crocatum leaves methanolic extract (PCM) on cell proliferation and migration by using 4T1 cells as model of metastatic breast cancer. By using MTT assay, PCM performed cytotoxic activity in a dose dependent manner with IC50 value of 120 μg/mL. Wound healing assay revealed that migration inhibitory activity of PCM on 4T1 cells at the concentration of 30 µg/mL. In conclusion, PCM perform cytotoxic effect and antimigration activity toward metastatic breast cancer cells.Keywords: breast cancer cells, Piper crocatum Ruiz & Pav, cytotoxic, cell mgration

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  • Universitas Gadjah Mada
  • Indonesian Institute of Sciences
  • Sultan Agung Islamic University
  • Universitas Jember
  • Sunan Kalijaga State Islamic University Yogyakarta
  • Universitas Wahid Hasyim
  • Padjadjaran University
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Rekan penulisOrganisasiArtikel bersama
Edy MeiyantoUniversitas Gadjah Mada17
Sri HandayaniIndonesian Institute of Sciences6
Ratna Asmah SusidartiUniversitas Gadjah Mada6
Rohmad Yudi UtomoUniversitas Gadjah Mada5
Annisa NovarinaUniversitas Gadjah Mada4
Adam HermawanUniversitas Gadjah Mada3
Argandita MeiftasariUniversitas Gadjah Mada3
Imroatus SholihahUniversitas Gadjah Mada3
Zalinar UdinIndonesian Institute of Sciences2
Yogi ErtantoUniversitas Gadjah Mada2
Muthi IkawatiUniversitas Gadjah Mada2
Laili Nailul MunaSunan Kalijaga State Islamic University Yogyakarta2
Laeli MuntafiahUniversitas Gadjah Mada2
Bani Adlina ShabrinaUniversitas Gadjah Mada2
Rumiyati RumiyatiUniversitas Gadjah Mada2
Dhania NovitasariUniversitas Gadjah Mada2
Prisnu TirtanirmalaUniversitas Gadjah Mada2
Devi Nisa HidayatiUniversitas Wahid Hasyim2
Marsya Yonna NurrachmaUniversitas Gadjah Mada2
Puspa Dewi LotulungIndonesian Institute of Sciences1
Akhmad DarmawanIndonesian Institute of Sciences1
Rosa AdelinaAfiliasi tidak diketahui1
Maria Dwi SupriyatiAfiliasi tidak diketahui1
Dwi Ana NawangsariAfiliasi tidak diketahui1
Dhiya Ulhaq SalsabilaPadjadjaran University1
Nisa Ul HasanahUniversitas Gadjah Mada1
Ahmad Syauqy TafrihaniUniversitas Gadjah Mada1
Ummi Maryam ZulfinUniversitas Gadjah Mada1
Ratih Kurnia WardaniUniversitas Gadjah Mada1
Agung PutraSultan Agung Islamic University1
Iffan AlifSultan Agung Islamic University1
Retno MurwantiUniversitas Gadjah Mada1
Yoce ApriantoUniversitas Gadjah Mada1
Asri Mega PutriUniversitas Gadjah Mada1
Dwi SulistyowatiUniversitas Gadjah Mada1
Murah Riski Novi AsshagabUniversitas Gadjah Mada1

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Sumber metadata: OAI-PMH (metadata jurnal) https://ijcc.chemoprev.org/index.php/ijcc/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Methanolic Extract of Red Betel Leaves (Piper crocatum Ruiz &amp; Pav) Perform Cytotoxic Effect and Antimigration Activity toward Metastatic Breast Cancer</dc:title>
	<dc:creator>Zulharini, Meirizky</dc:creator>
	<dc:creator>Sutejo, Ika Rahmawati</dc:creator>
	<dc:creator>Fadliyah, Hilyatul</dc:creator>
	<dc:creator>Jenie, Riris Istighfari</dc:creator>
	<dc:description xml:lang="en-US">Breast cancer is one type of cancer with a high mortality rate due to its metastatic property. Red betel leaves (Piper crocatum Ruiz and Pav) has been known as herbal medicine containing biophenolic, such as apigenin and luteolin derivatives which has cytotoxic activity toward cancer cells. This study is intended to explore the inhibitory effect of Piper crocatum leaves methanolic extract (PCM) on cell proliferation and migration by using 4T1 cells as model of metastatic breast cancer. By using MTT assay, PCM performed cytotoxic activity in a dose dependent manner with IC50 value of 120 μg/mL. Wound healing assay revealed that migration inhibitory activity of PCM on 4T1 cells at the concentration of 30 µg/mL. In conclusion, PCM perform cytotoxic effect and antimigration activity toward metastatic breast cancer cells.Keywords : breast cancer cells, Piper crocatum Ruiz &amp; Pav, cytotoxic, cell mgration</dc:description>
	<dc:publisher xml:lang="en-US">Indonesian Society for Cancer Chemoprevention</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2017-10-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US"></dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ijcc.chemoprev.org/index.php/ijcc/article/view/165</dc:identifier>
	<dc:identifier>10.14499/indonesianjcanchemoprev8iss3pp94-100</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Cancer Chemoprevention; Vol 8, No 3 (2017); 94-100</dc:source>
	<dc:source>2355-8989</dc:source>
	<dc:source>2088-0197</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ijcc.chemoprev.org/index.php/ijcc/article/view/165/145</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2018 Indonesian Journal of Cancer Chemoprevention</dc:rights>
</oai_dc:dc>