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Effects of Phaleria macrocarpa and Averrhoa bilimbi L. on fasting blood glucose in diabetic rats

International Journal of Advances in Applied Sciences · Vol. 15 No. 2 (2026) · hlm. 732–740

DOI
10.11591/ijaas.v15.i2.pp732-740
ISSN
2722-2594, 2252-8814
Terbit
2026-06-01
Penerbit
Institute of Advanced Engineering and Science
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-sa/4.0

Abstrak

Traditional ingredients have been proven to contain many substances that can be used to prevent and treat diabetes. This study aimed to investigate the effects of a combination of Phaleria macrocarpa and Averrhoa bilimbi L. extracts on fasting blood glucose levels. A randomized, post-test-controlled group design was used. Type 2 diabetes mellitus was induced in 36 Sprague Dawley rats by feeding them a high-fat diet for 2 weeks, followed by the administration of streptozotocin (STZ) and nicotinamide to induce type 2 diabetes mellitus. The rats were divided into six groups. The treatment was administered for 21 days, and fasting blood glucose levels were measured. The data were analyzed using one-way analysis of variance (ANOVA). The combined dose of Phaleria macrocarpa and Averrhoa bilimbi L. extract effectively reduced fasting blood glucose levels over 21 days. Group T1 demonstrated the highest efficacy and did not differ significantly from that of the C+ group. The effective dosage that influenced fasting blood glucose levels was a combination of Phaleria macrocarpa at 750 mg/kg W/day and Averrhoa bilimbi L. at 375 mg/kg. Phaleria macrocarpa and Averrhoa bilimbi L. extract have a synergistic effect, making them a promising natural medication for controlling blood glucose levels.

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  • Universitas Syiah Kuala
  • Universitas Islam Negeri Ar-Raniry
  • Poltekkes Kemenkes Banjarmasin
  • Sunan Kalijaga State Islamic University Yogyakarta
  • Universitas Islam Negeri Sumatera Utara
  • Universitas Islam Negeri Alauddin Makassar
  • Institut Agama Islam Negeri Bone
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  • Organisasi berbeda
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Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Niken Widyastuti HartatiPoltekkes Kemenkes Banjarmasin3
Malahayati MalahayatiUniversitas Islam Negeri Ar-Raniry2
Chairunnisa DjayadinSunan Kalijaga State Islamic University Yogyakarta1
Khairan ARUniversitas Islam Negeri Ar-Raniry1
Mawardi MawardiUniversitas Islam Negeri Ar-Raniry1
Malahayati UmarUniversitas Islam Negeri Ar-Raniry1
Mouliza AstariUniversitas Islam Negeri Ar-Raniry1
Fathiah FathiahUniversitas Islam Negeri Ar-Raniry1
Arika Dhien SartikaAfiliasi tidak diketahui1
Muhammad Rizal FachriUniversitas Islam Negeri Ar-Raniry1
Habibi AkbarUniversitas Syiah Kuala1
Ramdhan Halid SiregarUniversitas Syiah Kuala1
Rika Sri UtamiUniversitas Syiah Kuala1
Mahdi SyukriUniversitas Syiah Kuala1
Nurhayati NurhayatiUniversitas Islam Negeri Sumatera Utara1
Abdullah AbdullahUniversitas Islam Negeri Ar-Raniry1
Fadli Andi NatsifUniversitas Islam Negeri Alauddin Makassar1
Hasbi SiddikInstitut Agama Islam Negeri Bone1
Khairun SaddamiUniversitas Syiah Kuala1
Rika Sri UtamiUniversitas Syiah Kuala1
Akhyar AkhyarUniversitas Syiah Kuala1

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Sumber metadata: OAI-PMH (metadata jurnal) http://ijaas.iaescore.com/index.php/IJAAS/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Effects of Phaleria macrocarpa and Averrhoa bilimbi L. on fasting blood glucose in diabetic rats</dc:title>
	<dc:creator>Sholehah, Laila</dc:creator>
	<dc:creator>Fathurrahman, Fathurrahman</dc:creator>
	<dc:creator>Hariati, Niken Widyastuti</dc:creator>
	<dc:creator>Aprianti, Aprianti</dc:creator>
	<dc:description xml:lang="en-US">Traditional ingredients have been proven to contain many substances that can be used to prevent and treat diabetes. This study aimed to investigate the effects of a combination of Phaleria macrocarpa and Averrhoa bilimbi L. extracts on fasting blood glucose levels. A randomized, post-test-controlled group design was used. Type 2 diabetes mellitus was induced in 36 Sprague Dawley rats by feeding them a high-fat diet for 2 weeks, followed by the administration of streptozotocin (STZ) and nicotinamide to induce type 2 diabetes mellitus. The rats were divided into six groups. The treatment was administered for 21 days, and fasting blood glucose levels were measured. The data were analyzed using one-way analysis of variance (ANOVA). The combined dose of Phaleria macrocarpa and Averrhoa bilimbi L. extract effectively reduced fasting blood glucose levels over 21 days. Group T1 demonstrated the highest efficacy and did not differ significantly from that of the C+ group. The effective dosage that influenced fasting blood glucose levels was a combination of Phaleria macrocarpa at 750 mg/kg W/day and Averrhoa bilimbi L. at 375 mg/kg. Phaleria macrocarpa and Averrhoa bilimbi L. extract have a synergistic effect, making them a promising natural medication for controlling blood glucose levels.</dc:description>
	<dc:publisher xml:lang="en-US">Institute of Advanced Engineering and Science</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2026-06-01</dc:date>
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	<dc:identifier>https://ijaas.iaescore.com/index.php/IJAAS/article/view/21804</dc:identifier>
	<dc:identifier>10.11591/ijaas.v15.i2.pp732-740</dc:identifier>
	<dc:source xml:lang="en-US">International Journal of Advances in Applied Sciences; Vol 15, No 2: June 2026; 732-740</dc:source>
	<dc:source>2722-2594</dc:source>
	<dc:source>2252-8814</dc:source>
	<dc:source>10.11591/ijaas.v15.i2</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ijaas.iaescore.com/index.php/IJAAS/article/view/21804/13456</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2026 Laila Sholehah, Fathurrahman Fathurrahman, Niken Widyastuti Hariati, Aprianti</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-sa/4.0</dc:rights>
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