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Phthalates exposure as environmental risk factor for type 2 diabetes mellitus

International Journal of Public Health Science · Vol. 12 No. 1 (2023) · hlm. 172–180

DOI
10.11591/ijphs.v12i1.22280
ISSN
2620-4126, 2252-8806
Terbit
2023-03-01
Penerbit
Intelektual Pustaka Media Utama
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc/4.0

Abstrak

Phthalates exposure occurs in all areas, such as foods' plastic packaging, cosmetics, and others. Previous studies showed that phthalates are associated with the prevalence of T2DM. Type 2 Diabetes Mellitus (T2DM) is caused by a combination of defective insulin secretion by pancreatic β-cells and the insulin-resistance. This study aimed to investigate whether phthalate exposure is an environmental risk factor for T2DM. A case-control study was conducted among residents in the South Tangerang district from June 2020 to February 2021 using a purposive sampling technique. The cases were the patients diagnosed T2DM with HbA1c>6.5% random blood sugar>200 mg/dL, with history T2DM treatment. The respondents' urines were collected and evaluated using liquid chromatography/mass spectrometry (LC/MS). A total of 47 cases and 47 controls were recruited in the study. The lowest monomethyl phthalate (MEP) and mono (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) were 5.37 µg/L and 2.02 µg/L, respectively. On multivariable regression analysis, the high urinary MEP level (>131.91 µg/L) was independently associated with T2DM (OR: 3.754, 95% CI: 1.559–8.811, p-value: 0.002). MEP is an environmental risk factor for T2DM and likely has a significant impact on human health than MEHHP.

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  • Universitas Esa Unggul
  • Universitas Syiah Kuala
  • Universitas Islam Negeri Sumatera Utara
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Apoina KartiniAfiliasi tidak diketahui6
Zahroh ShaluhiyahAfiliasi tidak diketahui4
Ratih IndraswariAfiliasi tidak diketahui4
Novia HandayaniAfiliasi tidak diketahui3
Budiyono BudiyonoAfiliasi tidak diketahui3
Sri Achadi NugraheniAfiliasi tidak diketahui2
Samingan SaminganAfiliasi tidak diketahui2
Martha Irene KartasuryaAfiliasi tidak diketahui2
P.W. NoviantiAfiliasi tidak diketahui2
Aditya KusumawatiAfiliasi tidak diketahui2
Mateus Sakundarno AdiAfiliasi tidak diketahui2
Dwi SutiningsihAfiliasi tidak diketahui2
Sultana MH FaradzAfiliasi tidak diketahui2
Ariana ArianaAfiliasi tidak diketahui1
Moch Taufik HidayatullahAfiliasi tidak diketahui1
Dyah Hapsari PrananingrumAfiliasi tidak diketahui1
Endang HaryaniAfiliasi tidak diketahui1
Vivi Retno InteningAfiliasi tidak diketahui1
. SuhartonoAfiliasi tidak diketahui1
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Fice HandayaniAfiliasi tidak diketahui1
Ratna Catur WidyaningtyaAfiliasi tidak diketahui1
Fitri Alaida AlfianaAfiliasi tidak diketahui1
Andi Ulfa Tenri PadaUniversitas Syiah Kuala1
Iswadi IswadiUniversitas Esa Unggul1
Tara Raudhatul JannahAfiliasi tidak diketahui1
Syaukani SyaukaniUniversitas Islam Negeri Sumatera Utara1
Alfizar AlfizarAfiliasi tidak diketahui1
Zulia AnandaAfiliasi tidak diketahui1
Sirtina SirtinaAfiliasi tidak diketahui1
Oviana LisaAfiliasi tidak diketahui1
Czeresna Heriawan SoejonoAfiliasi tidak diketahui1
Yudo Murti MupangatiAfiliasi tidak diketahui1
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Abd HadiAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) http://ijphs.iaescore.com/index.php/IJPHS/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Phthalates exposure as environmental risk factor for type 2 diabetes mellitus</dc:title>
	<dc:creator>Fauziah, Munaya</dc:creator>
	<dc:creator>Suhartono, Suhartono</dc:creator>
	<dc:creator>Widjanarko, Bagoes</dc:creator>
	<dc:creator>Gasem, Muhammad Hussein</dc:creator>
	<dc:description xml:lang="en-US">Phthalates exposure occurs in all areas, such as foods' plastic packaging, cosmetics, and others. Previous studies showed that phthalates are associated with the prevalence of T2DM. Type 2 Diabetes Mellitus (T2DM) is caused by a combination of defective insulin secretion by pancreatic β-cells and the insulin-resistance. This study aimed to investigate whether phthalate exposure is an environmental risk factor for T2DM. A case-control study was conducted among residents in the South Tangerang district from June 2020 to February 2021 using a purposive sampling technique. The cases were the patients   diagnosed T2DM with HbA1c&amp;gt;6.5% random blood sugar&amp;gt;200 mg/dL, with history T2DM treatment. The respondents' urines were collected and evaluated using liquid chromatography/mass spectrometry (LC/MS). A total of 47 cases and 47 controls were recruited in the study. The lowest monomethyl phthalate (MEP) and mono (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) were 5.37 µg/L and 2.02 µg/L, respectively. On multivariable regression analysis, the high urinary MEP level (&amp;gt;131.91 µg/L) was independently associated with T2DM (OR: 3.754, 95% CI: 1.559–8.811, p-value: 0.002). MEP is an environmental risk factor for T2DM and likely has a significant impact on human health than MEHHP.</dc:description>
	<dc:publisher xml:lang="en-US">Intelektual Pustaka Media Utama</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2023-03-01</dc:date>
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	<dc:identifier>https://ijphs.iaescore.com/index.php/IJPHS/article/view/22280</dc:identifier>
	<dc:identifier>10.11591/ijphs.v12i1.22280</dc:identifier>
	<dc:source xml:lang="en-US">International Journal of Public Health Science (IJPHS); Vol 12, No 1: March 2023; 172-180</dc:source>
	<dc:source>2620-4126</dc:source>
	<dc:source>2252-8806</dc:source>
	<dc:source>10.11591/ijphs.v12i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ijphs.iaescore.com/index.php/IJPHS/article/view/22280/13733</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2022 Institute of Advanced Engineering and Science</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-nc/4.0</dc:rights>
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