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Determinants Levels of Urinary 8-Hydroxydeoxyguanosine among Chromium Electroplating Workers

International Journal of Public Health Science · Vol. 5 No. 4 (2016) · hlm. 422–426

DOI
10.11591/ijphs.v5i4.4845
ISSN
2620-4126, 2252-8806
Terbit
2016-12-01
Penerbit
Intelektual Pustaka Media Utama
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc/4.0

Abstrak

Electroplating workers were exposed by particulate and fog of chromium from electrolysis process during work. Chromium is highly carcinogenic when inhaled. Chromium can be reduced in the cells in the body. This process may generate Reactive Oxygen Species (ROS) causing lipid peroxidation and oxidative DNA damage. This research was aimed to analyse the influence of chromium to the levels of urinary 8-OHdG as an indicator to support early diagnosis of occupational disease. 66 electroplating workers in Tegal District were taken purposively as samples for this research. There were association between chromium level in urine, malondialdehyde (MDA) level, Body Mass Index, smoking habit, alcohol and supplement drink consumption and urinary 8-OHdG (p 0.05). Multivariate analysis using logistic regression showed the alcohol consumption had the most powerful influence to the level of urinary 8-OHdG. The levels of urinary 8-OHdG could be used as an indicator of oxidative DNA damage and early diagnosis of occupational disease among electroplating workers who were exposed by chromium.

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  • Universitas Gadjah Mada
  • Diponegoro University
  • State University of Semarang
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Daru LestantyoAfiliasi tidak diketahui6
Dina Lusiana SetyowatiAfiliasi tidak diketahui4
Hanifa M. DennyAfiliasi tidak diketahui2
Chriswardani SuryawatiAfiliasi tidak diketahui2
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Henry Setiawan SusantoAfiliasi tidak diketahui1
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Anies AniesAfiliasi tidak diketahui1
Fakhria MaulidaAfiliasi tidak diketahui1
Hanifa DennyAfiliasi tidak diketahui1
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Siswi JayantiAfiliasi tidak diketahui1
Risa Septi AstutikAfiliasi tidak diketahui1
Kusworo AdiDiponegoro University1
Dyah Dewi HastutiAfiliasi tidak diketahui1
Sugiharto SugihartoAfiliasi tidak diketahui1
Evi WidowatiAfiliasi tidak diketahui1
Anik Setyo WahyuningsihState University of Semarang1
Wahyudi IstionoAfiliasi tidak diketahui1
Sutopo Patria JatiAfiliasi tidak diketahui1
IksaruddinAfiliasi tidak diketahui1
Onny SetianiAfiliasi tidak diketahui1
Suroto SurotoAfiliasi tidak diketahui1
Eli SahirohAfiliasi tidak diketahui1
Munakhir MudjosemediUniversitas Gadjah Mada1
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Sofia SofiaUniversitas Nurul Jadid1
Susi IravatiUniversitas Gadjah Mada1

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Sumber metadata: OAI-PMH (metadata jurnal) http://ijphs.iaescore.com/index.php/IJPHS/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Determinants Levels of Urinary 8-Hydroxydeoxyguanosine among Chromium Electroplating Workers</dc:title>
	<dc:creator>Setyaningsih, Yuliani</dc:creator>
	<dc:creator>Astuti, Indwiani</dc:creator>
	<dc:creator>Husodo, Adi Heru</dc:creator>
	<dc:description xml:lang="en-US">Electroplating workers were exposed by particulate and fog of chromium from electrolysis process during work. Chromium is highly carcinogenic when inhaled.  Chromium can be reduced in the cells in the body. This process may generate Reactive Oxygen Species (ROS) causing lipid peroxidation and oxidative DNA damage. This research was aimed to analyse the influence of chromium to the levels of urinary 8-OHdG as an indicator to support early diagnosis of occupational disease. 66 electroplating workers in Tegal District were taken purposively as samples for this research. There were association between chromium level in urine, malondialdehyde (MDA) level, Body Mass Index, smoking habit, alcohol and supplement drink consumption and urinary 8-OHdG (p&amp;lt;0.05). There was not association between BMI and urinary 8-OHdG (p&amp;gt;0.05). Multivariate analysis using logistic regression showed the alcohol consumption had the most powerful influence to the level of urinary 8-OHdG. The levels of urinary 8-OHdG could be used as an indicator of oxidative DNA damage and early diagnosis of occupational disease among electroplating workers who were exposed by chromium.</dc:description>
	<dc:publisher xml:lang="en-US">Intelektual Pustaka Media Utama</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2016-12-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US"></dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ijphs.iaescore.com/index.php/IJPHS/article/view/4845</dc:identifier>
	<dc:identifier>10.11591/ijphs.v5i4.4845</dc:identifier>
	<dc:source xml:lang="en-US">International Journal of Public Health Science (IJPHS); Vol 5, No 4: December 2016; 422-426</dc:source>
	<dc:source>2620-4126</dc:source>
	<dc:source>2252-8806</dc:source>
	<dc:source>10.11591/ijphs.v5i4</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ijphs.iaescore.com/index.php/IJPHS/article/view/4845/8613</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2016 International Journal of Public Health Science (IJPHS)</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-nc/4.0</dc:rights>
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