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Morphological and Mechanical Study of Gelatin/Hydroxyapatite Composite based Scaffolds for Bone Tissue Regeneration

INDONESIAN JOURNAL OF APPLIED PHYSICS · Vol. 12 No. 2 (2022) · hlm. 235–241

DOI
10.13057/ijap.v12i2.59365
ISSN
2477-6416, 2089-0133
Terbit
2022-10-04
Penerbit
Department of Physics, Sebelas Maret University
Bahasa
eng

Abstrak

Gelatin-Hydroxyapatite (GHA) composite has been synthesized as a scaffold in bone tissue engineering. The purpose of this study was to find the optimal composition of the GHA scaffold composite which has the best mechanical properties. The independent variable in this study was the composition of HAp. Hydroxyapatite was synthesized by precipitation method from Ca(OH)2 and (NH4)2HPO4 as raw materials. Scaffold from GHA Composite was made by freeze-drying technique with freezing time for 8 hours at -80º C and drying with lyophilizer. The results were characterized using XRD, optical microscopy and tested for compressive strength. The results of the XRD showed that there was no change in a compound or the formation of new bonds on the GHA scaffold when it became a composite which was indicated by the absence of new peaks. It is also known that the peaks decrease in intensity as the amount of polymer in the composite increases. The highest degree of crystallinity was found in the 1:3 GHA sample because it had the highest concentration of HAp. The results of observations with an optical microscope showed that the most homogeneous pore surface morphology was GHA 1:2 with an average pore size of 225.12 ± 16.57 μm. From the results of the compressive strength test, the best value for the 1:2 GHA scaffold was 18.1 ± 0.61 MPa. The values obtained by this scaffold are following the minimum requirements for canceled scaffold so that it can be used as a scaffold candidate in bone tissue engineering.

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  • University of Brawijaya
  • Universitas Islam Negeri Mataram
  • State University of Semarang
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Rekan penulisOrganisasiArtikel bersama
Rachmat Triandi TjahjantoUniversity of Brawijaya2
Gancang SarojaUniversity of Brawijaya2
Yunita Dyah Puspita SantikState University of Semarang1
Maf'ud CahayoAfiliasi tidak diketahui1
Alfiatur RahmahUniversity of Brawijaya1
Ahmad ZainollahUniversity of Brawijaya1
Novi Artika FitrianiUniversity of Brawijaya1
Dwi Sapri RamadhanUniversity of Brawijaya1
Lalu Ahmad DidikUniversitas Islam Negeri Mataram1
Yahdi YahdiUniversitas Islam Negeri Mataram1
Simon Bambang WidjanarkoUniversity of Brawijaya1
Sutiman Bambang SumitroUniversity of Brawijaya1
Hostalige HutasoitUniversity of Brawijaya1
PurnamiAfiliasi tidak diketahui1
Willy Satrio NugrohoUniversity of Brawijaya1
I.N.G. WardanaUniversity of Brawijaya1
Fitria Indra SeptiUniversity of Brawijaya1

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Sumber metadata: OAI-PMH (metadata jurnal) https://jurnal.uns.ac.id/ijap/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Morphological and Mechanical Study of Gelatin/Hydroxyapatite Composite based Scaffolds for Bone Tissue Regeneration</dc:title>
	<dc:creator>Nawafi, Moh Rifqi</dc:creator>
	<dc:creator>Masruroh, Masruroh</dc:creator>
	<dc:creator>Santjojo, Dionysius Joseph Djoko Herry</dc:creator>
	<dc:subject xml:lang="en-US">composite scaffolds; compressive strength; gelatin; hydroxyapatite</dc:subject>
	<dc:description xml:lang="en-US">Gelatin-Hydroxyapatite (GHA) composite has been synthesized as a scaffold in bone tissue engineering. The purpose of this study was to find the optimal composition of the GHA scaffold composite which has the best mechanical properties. The independent variable in this study was the composition of HAp. Hydroxyapatite was synthesized by precipitation method from Ca(OH)2 and (NH4)2HPO4 as raw materials. Scaffold from GHA Composite was made by freeze-drying technique with freezing time for 8 hours at -80º C and drying with lyophilizer. The results were characterized using XRD, optical microscopy and tested for compressive strength. The results of the XRD showed that there was no change in a compound or the formation of new bonds on the GHA scaffold when it became a composite which was indicated by the absence of new peaks. It is also known that the peaks decrease in intensity as the amount of polymer in the composite increases. The highest degree of crystallinity was found in the 1:3 GHA sample because it had the highest concentration of HAp. The results of observations with an optical microscope showed that the most homogeneous pore surface morphology was GHA 1:2 with an average pore size of 225.12 ± 16.57 μm. From the results of the compressive strength test, the best value for the 1:2 GHA scaffold was 18.1 ± 0.61 MPa. The values obtained by this scaffold are following the minimum requirements for canceled scaffold so that it can be used as a scaffold candidate in bone tissue engineering.</dc:description>
	<dc:publisher xml:lang="en-US">Department of Physics, Sebelas Maret University</dc:publisher>
	<dc:contributor xml:lang="en-US">the Laboratory of Sensor Technology of Brawijaya University</dc:contributor>
	<dc:date>2022-10-04</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jurnal.uns.ac.id/ijap/article/view/59365</dc:identifier>
	<dc:identifier>10.13057/ijap.v12i2.59365</dc:identifier>
	<dc:source xml:lang="en-US">INDONESIAN JOURNAL OF APPLIED PHYSICS; Vol 12, No 2 (2022): October; 235-241</dc:source>
	<dc:source>2477-6416</dc:source>
	<dc:source>2089-0133</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jurnal.uns.ac.id/ijap/article/view/59365/37676</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2022 INDONESIAN JOURNAL OF APPLIED PHYSICS</dc:rights>
</oai_dc:dc>