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Solanum nigrum Ethanolic Extract (SNE) Increases Cytotoxic Activity of Doxorubicin on MCF-7 Cell

Indonesian Journal of Cancer Chemoprevention · Vol. 12 No. 2 (2021) · hlm. 67–73

DOI
10.14499/indonesianjcanchemoprev12iss2pp67-73
ISSN
2355-8989, 2088-0197
Terbit
2021-06-30
Penerbit
Indonesian Society for Cancer Chemoprevention
Bahasa
eng

Abstrak

Leunca (Solanum nigrum L.) is a potential source of natural anticancer agents. Solanum nigrum L. ethanolic extract (SNE) has cytotoxic activity in several cancer cell lines. We aimed to evaluate the ability of SNE to increase MCF-7 cell sensitivity to doxorubicin as a chemotherapeutic agent for breast cancer. Cell viability of SNE and its combination treatment with doxorubicin were conducted by 3-(4,5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) assay, and apoptosis assay was analyzed by Ethidium bromide-acridine orange method. The SNE showed a cytotoxic effect in the MCF-7 cell line with IC50 50 μg/mL. Combination treated DOX-SNE resulted in a combination index (CI) value of 0.21, indicating strong synergism SNE and doxorubicin. The SNE 25 μg/mL combined with doxorubicin 100 nM optimally induced apoptosis of MCF-7 cells. We concluded that SNE is the potential to be developed as a co-chemotherapeutic agent through apoptosis induction though the molecular mechanism need to explore.Keywords: Solanum nigrum L. herb ethanolic extract, doxorubicin, MCF-7, apoptosis.

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  • Universitas Gadjah Mada
  • Indonesian Institute of Sciences
  • Kementerian Kesehatan Republik Indonesia
  • Nara Institute of Science and Technology
  • Atma Jaya University Yogyakarta
  • Muhammadiyah University Purwokerto
  • Sumatera Institute of Technology
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Rekan penulisOrganisasiArtikel bersama
Adam HermawanUniversitas Gadjah Mada19
Ratna Asmah SusidartiUniversitas Gadjah Mada17
Riris Istighfari JenieUniversitas Gadjah Mada15
Muthi IkawatiUniversitas Gadjah Mada15
Rohmad Yudi UtomoUniversitas Gadjah Mada9
Faaza Aulia RahmanUniversitas Gadjah Mada6
Sari HaryantiKementerian Kesehatan Republik Indonesia5
Dhania NovitasariUniversitas Gadjah Mada4
Retno MurwantiUniversitas Gadjah Mada4
Desty Restia RahmawatiUniversitas Gadjah Mada4
Ummi Maryam ZulfinUniversitas Gadjah Mada4
Anindyajati AnindyajatiUniversitas Gadjah Mada4
Larasati LarasatiUniversitas Gadjah Mada4
Herwandhani PutriUniversitas Gadjah Mada4
Sri HandayaniIndonesian Institute of Sciences3
Sarmoko SarmokoSumatera Institute of Technology3
Yonika Arum LarasatiUniversitas Gadjah Mada3
Nanda Resa PratamaUniversitas Gadjah Mada3
Astrid Ayu MarutiUniversitas Gadjah Mada3
Masashi KawaichiNara Institute of Science and Technology2
Sendy JunediAtma Jaya University Yogyakarta2
Nunuk Aries NurulitaMuhammadiyah University Purwokerto2
Suwijiyo PramonoUniversitas Gadjah Mada2
Zalinar UdinIndonesian Institute of Sciences2
Yogi ErtantoUniversitas Gadjah Mada2
Lailatul QodriaUniversitas Gadjah Mada2
Gergorius Gena MaranUniversitas Gadjah Mada2
Aulia Nur SeptianiUniversitas Gadjah Mada2
Sofa FaridaUniversitas Gadjah Mada2
Beni LestariUniversitas Gadjah Mada2
Asri Mega PutriUniversitas Gadjah Mada2
Hilyatul FadliyahUniversitas Gadjah Mada2
Indri KusharyantiTanjungpura University2
Ni Putu Linda LaksmianiUdayana University2
Yurista GilangUniversitas Gadjah Mada2
Nur IsmiyatiPoliteknik Kesehatan Bhakti Setya Indonesia2

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Sumber metadata: OAI-PMH (metadata jurnal) https://ijcc.chemoprev.org/index.php/ijcc/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Solanum nigrum Ethanolic Extract (SNE) Increases Cytotoxic Activity of Doxorubicin on MCF-7 Cell</dc:title>
	<dc:creator>Putri, Dyaningtyas Dewi Pamungkas</dc:creator>
	<dc:creator>Rivanti, Erlina</dc:creator>
	<dc:creator>Istiaji, Raditya Prima</dc:creator>
	<dc:creator>Meiyanto, Edy</dc:creator>
	<dc:description xml:lang="en-US">Leunca (Solanum nigrum L.) is a potential source of natural anticancer agents. Solanum nigrum L. ethanolic extract (SNE) has cytotoxic activity in several cancer cell lines. We aimed to evaluate the ability of SNE to increase MCF-7 cell sensitivity to doxorubicin as a chemotherapeutic agent for breast cancer. Cell viability of SNE and its combination treatment with doxorubicin were conducted by 3-(4,5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) assay, and apoptosis assay was analyzed by Ethidium bromide-acridine orange method. The SNE showed a cytotoxic effect in the MCF-7 cell line with IC50 50 μg/mL. Combination treated DOX-SNE resulted in a combination index (CI) value of 0.21, indicating strong synergism SNE and doxorubicin. The SNE 25 μg/mL combined with doxorubicin 100 nM optimally induced apoptosis of MCF-7 cells. We concluded that SNE is the potential to be developed as a co-chemotherapeutic agent through apoptosis induction though the molecular mechanism need to explore.Keywords: Solanum nigrum L. herb ethanolic extract, doxorubicin, MCF-7, apoptosis.</dc:description>
	<dc:publisher xml:lang="en-US">Indonesian Society for Cancer Chemoprevention</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2021-06-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
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	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ijcc.chemoprev.org/index.php/ijcc/article/view/357</dc:identifier>
	<dc:identifier>10.14499/indonesianjcanchemoprev12iss2pp67-73</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Cancer Chemoprevention; Vol 12, No 2 (2021); 67-73</dc:source>
	<dc:source>2355-8989</dc:source>
	<dc:source>2088-0197</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ijcc.chemoprev.org/index.php/ijcc/article/view/357/236</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2021 Indonesian Journal of Cancer Chemoprevention</dc:rights>
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