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Cytotoxic Potential of Flavonoid from Nicotiana tabacum Leaves on MCF-7 Human Breast Cancer Cells

Indonesian Journal of Cancer Chemoprevention · Vol. 11 No. 2 (2020) · hlm. 97–102

DOI
10.14499/indonesianjcanchemoprev11iss2pp97-10
ISSN
2355-8989, 2088-0197
Terbit
2020-06-30
Penerbit
Indonesian Society for Cancer Chemoprevention
Bahasa
eng

Abstrak

Flavonoid has potential bioactivity as anticancer agents. The flavonoid of cultivated tobacco (Nicotiana tabacum), locally known as “Kasturi”, leaves was screened for its cytotoxicity against MCF-7 human breast cancer cells and non-transformed Vero cells (African normal cell kidney line) in different concentrations. This study aimed to examine the cytotoxic potential of the flavonoid of Kasturi tobacco leaves against MCF-7 human breast cancer cells. Flavonoid obtained from methanolic extracts of Kasturi tobacco leaves, which have been purified from nicotine. The flavonoid of Kasturi tobacco leaves with concentrations of 20 to 640 μg/mL were exposed to MCF-7 and Vero cells for 24 h. Cell viability was evaluated by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. Flavonoid of Kasturi tobacco leaves with concentrations of 160 μg/mL decreased the MCF-7 cell viability more than 50%, with an inhibitory concentration 50 (IC50) value of 148.41 μg/mL. Meanwhile, it inhibited 50% of Vero cell viability at 255.35 μg/mL. The flavonoid of Kasturi tobacco leaves has cytotoxic activity on MCF-7 cells, and might be a potential alternative agent for human breast cancer therapy.Keywords: flavonoid, tobacco leaves, human breast cancer cells, anticancer activity

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  • Universitas Gadjah Mada
  • Universitas Jember
  • Universitas Airlangga
  • Universitas Hang Tuah
  • Mahsa University
  • King Khalid University
  • Rumah Sakit Umum Pusat Dr. Sardjito
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Rekan penulisOrganisasiArtikel bersama
Dwi Merry Christmarini RobinUniversitas Gadjah Mada3
Irma Josefina SavitriUniversitas Airlangga2
Dea Ajeng Pravita SuendiUniversitas Jember2
Andhika Puspito NugrohoUniversitas Gadjah Mada1
Pairah PairahAfiliasi tidak diketahui1
Irfan Agus NugrohoUniversitas Gadjah Mada1
Ananda Briliana RomadhonaUniversitas Gadjah Mada1
Christabel Reviana SeptianingtyasUniversitas Gadjah Mada1
Laila Nurul IlmaUniversitas Gadjah Mada1
Ludmilla Fitri UntariUniversitas Gadjah Mada1
Widya AsmaraUniversitas Gadjah Mada1
Marsetyawan H. N. E. SoesatyoUniversitas Gadjah Mada1
Djaswadi DasukiUniversitas Gadjah Mada1
Zahara MeilawatyUniversitas Jember1
Agustin Wulan Suci DharmayantiUniversitas Jember1
Chiquita PrahasantiAfiliasi tidak diketahui1
I Komang Evan WijaksanaUniversitas Airlangga1
Padmini HariMahsa University1
Niken Luthfiyya AriniUniversitas Airlangga1
Kurnia Dwi WulanUniversitas Airlangga1
Onge Victoria HendroUniversitas Hang Tuah1
Noer UlfahUniversitas Airlangga1
Shahabe Saquib AbullaisKing Khalid University1
Edy MeiyantoUniversitas Gadjah Mada1
Nunuk PurwantiUniversitas Gadjah Mada1
Retno ArdhaniUniversitas Gadjah Mada1
Dhania NovitasariUniversitas Gadjah Mada1
Faaza Aulia RahmanUniversitas Gadjah Mada1
Sugeng RiyantoUniversitas Gadjah Mada1
Endah Dwi SetyowatiRumah Sakit Umum Pusat Dr. Sardjito1
Binar Asrining DhianiMuhammadiyah University Purwokerto1
Rifki FebriansahMuhammadiyah University of Yogyakarta1
Dyaningtyas Dewi Pamungkas PutriUniversitas Gadjah Mada1
Sarmoko SarmokoSumatera Institute of Technology1

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Sumber metadata: OAI-PMH (metadata jurnal) https://ijcc.chemoprev.org/index.php/ijcc/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Cytotoxic Potential of Flavonoid from Nicotiana tabacum Leaves on MCF-7 Human Breast Cancer Cells</dc:title>
	<dc:creator>Kusumawardani, Banun</dc:creator>
	<dc:creator>Febi, Qonita Nafilah</dc:creator>
	<dc:creator>Rosidah, Malihatul</dc:creator>
	<dc:creator>Azis, Deri Abdul</dc:creator>
	<dc:creator>Puspitasari, Endah</dc:creator>
	<dc:creator>Nugraha, Ari Satia</dc:creator>
	<dc:description xml:lang="en-US">Flavonoid has potential bioactivity as anticancer agents. The flavonoid of cultivated tobacco (Nicotiana tabacum), locally known as “Kasturi”, leaves was screened for its cytotoxicity against MCF-7 human breast cancer cells and non-transformed Vero cells (African normal cell kidney line) in different concentrations. This study aimed to examine the cytotoxic potential of the flavonoid of Kasturi tobacco leaves against MCF-7 human breast cancer cells. Flavonoid obtained from methanolic extracts of Kasturi tobacco leaves, which have been purified from nicotine. The flavonoid of Kasturi tobacco leaves with concentrations of 20 to 640 μg/mL were exposed to MCF-7 and Vero cells for 24 h. Cell viability was evaluated by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. Flavonoid of Kasturi tobacco leaves with concentrations of 160 μg/mL decreased the MCF-7 cell viability more than 50%, with an inhibitory concentration 50 (IC50) value of 148.41 μg/mL. Meanwhile, it inhibited 50% of Vero cell viability at 255.35 μg/mL. The flavonoid of Kasturi tobacco leaves has cytotoxic activity on MCF-7 cells, and might be a potential alternative agent for human breast cancer therapy.Keywords: flavonoid, tobacco leaves, human breast cancer cells, anticancer activity</dc:description>
	<dc:publisher xml:lang="en-US">Indonesian Society for Cancer Chemoprevention</dc:publisher>
	<dc:contributor xml:lang="en-US">The Lembaga Penelitian dan Pengabdian Masyarakat, University of Jember, the Ministry of Research, Technology and Higher Education of Indonesia</dc:contributor>
	<dc:date>2020-06-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US"></dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ijcc.chemoprev.org/index.php/ijcc/article/view/273</dc:identifier>
	<dc:identifier>10.14499/indonesianjcanchemoprev11iss2pp97-10</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Cancer Chemoprevention; Vol 11, No 2 (2020); 97-102</dc:source>
	<dc:source>2355-8989</dc:source>
	<dc:source>2088-0197</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ijcc.chemoprev.org/index.php/ijcc/article/view/273/219</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2020 Indonesian Journal of Cancer Chemoprevention</dc:rights>
</oai_dc:dc>