Melola Discovery

← Melola Discovery

Jurnal SINTA 1

Ethanolic Extract of Hedyotis corymbosa L. Inhibits Migration and MMP-9 Activity on Metastatic Breast Cancer Cells

Indonesian Journal of Cancer Chemoprevention · Vol. 9 No. 1 (2018) · hlm. 16–22

DOI
10.14499/indonesianjcanchemoprev9iss1pp16-22
ISSN
2355-8989, 2088-0197
Terbit
2018-02-28
Penerbit
Indonesian Society for Cancer Chemoprevention
Bahasa
eng

Abstrak

Many natural products have been widely explored for their pharmacological activities, including anticancer activity. Hedyotis corymbosa L. is known for its anticancer properties toward several cancer cell lines. The study aims to investigate whether ethanolic extract of Hedyotis corymbosa L. (EEH) performs anticancer properties by inhibiting migration and metastasis on breast cancer cells. Cytotoxic evaluation by using MTT assay was carried out to determine EEH effect on 4T1 breast cancer cells, meanwhile to investigate the treatment of EEH in migration and metastasis inhibitory effect, scratch wound healing assay and gelatin zymography were conducted in this study. The data showed that EEH possessed cytotoxic activity with IC50 value of 400 μg/mL. Interestingly, migration inhibitory effect was shown up to 42 hours and the activity of MMP-9 was also decreased after the treatment with EEH. According to these findings, we suggest that Hedyotis corymbosa L. promotes another anticancer properties by inhibiting migration and metastasis towards breast cancer cells.Keywords: Hedyotis corymbosa L., cytotoxicity, migration, metastatic, 4T1 breast cancer cells

Jaringan kolaborasi para penulis

40 penulis · 140 tautan kepenulisan bersama · 41 lintas organisasi · menampilkan 40 yang paling banyak terhubung

Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.

  • Universitas Gadjah Mada
  • Indonesian Institute of Sciences
  • National Research and Innovation Agency
  • Sunan Kalijaga State Islamic University Yogyakarta
  • Universitas Wahid Hasyim
  • Universitas Bina Bangsa
  • Universitas Jember
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
  • Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel
Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Edy MeiyantoUniversitas Gadjah Mada22
Ratna Asmah SusidartiUniversitas Gadjah Mada10
Rohmad Yudi UtomoUniversitas Gadjah Mada5
Zalinar UdinIndonesian Institute of Sciences5
Adam HermawanUniversitas Gadjah Mada4
Annisa NovarinaUniversitas Gadjah Mada3
Laeli MuntafiahUniversitas Gadjah Mada3
Imroatus SholihahUniversitas Gadjah Mada3
Yogi ErtantoUniversitas Gadjah Mada2
Muthi IkawatiUniversitas Gadjah Mada2
Laili Nailul MunaSunan Kalijaga State Islamic University Yogyakarta2
Bani Adlina ShabrinaUniversitas Gadjah Mada2
Rumiyati RumiyatiUniversitas Gadjah Mada2
Argandita MeiftasariUniversitas Gadjah Mada2
Hilyatul FadliyahUniversitas Gadjah Mada2
Prisnu TirtanirmalaUniversitas Gadjah Mada2
Devi Nisa HidayatiUniversitas Wahid Hasyim2
Meirizky Zulharini S.Universitas Gadjah Mada2
Puspa Dewi LotulungIndonesian Institute of Sciences2
Akhmad DarmawanIndonesian Institute of Sciences2
Beni LestariUniversitas Gadjah Mada2
Dwi Ni’maturrohmahAfiliasi tidak diketahui1
Cici DarsihNational Research and Innovation Agency1
Marlyn Dian LaksitoriniUniversitas Gadjah Mada1
Hani SusantiNational Research and Innovation Agency1
Noor HidhayatiNational Research and Innovation Agency1
Anastasia Wheni IndrianingsihNational Research and Innovation Agency1
Rizal Maulana HasbyUniversitas Bina Bangsa1
Nunuk PurwantiUniversitas Gadjah Mada1
Banun KusumawardaniUniversitas Jember1
Dwi Merry Christmarini RobinUniversitas Gadjah Mada1
Retno ArdhaniUniversitas Gadjah Mada1
Faaza Aulia RahmanUniversitas Gadjah Mada1
Rosa AdelinaAfiliasi tidak diketahui1
Maria Dwi SupriyatiAfiliasi tidak diketahui1
Dwi Ana NawangsariAfiliasi tidak diketahui1
Nur Fitra SariUniversitas Gadjah Mada1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) https://ijcc.chemoprev.org/index.php/ijcc/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Ethanolic Extract of Hedyotis corymbosa L. Inhibits Migration and MMP-9 Activity on Metastatic Breast Cancer Cells</dc:title>
	<dc:creator>Novitasari, Dhania</dc:creator>
	<dc:creator>Handayani, Sri</dc:creator>
	<dc:creator>Jenie, Riris Istighfari</dc:creator>
	<dc:description xml:lang="en-US">Many natural products have been widely explored for their pharmacological activities, including anticancer activity. Hedyotis corymbosa L. is known for its anticancer properties toward several cancer cell lines. The study aims to investigate whether ethanolic extract of Hedyotis corymbosa L. (EEH) performs anticancer properties by inhibiting migration and metastasis on breast cancer cells. Cytotoxic evaluation by using MTT assay was carried out to determine EEH effect on 4T1 breast cancer cells, meanwhile to investigate the treatment of EEH in migration and metastasis inhibitory effect, scratch wound healing assay and gelatin zymography were conducted in this study. The data showed that EEH possessed cytotoxic activity with IC50 value of 400 μg/mL.  Interestingly, migration inhibitory effect was shown up to 42 hours and the activity of MMP-9 was also decreased after the treatment with EEH. According to these findings, we suggest that Hedyotis corymbosa L. promotes another anticancer properties by inhibiting migration and metastasis towards breast cancer cells.Keywords : Hedyotis corymbosa L., cytotoxicity, migration, metastatic, 4T1 breast cancer cells</dc:description>
	<dc:publisher xml:lang="en-US">Indonesian Society for Cancer Chemoprevention</dc:publisher>
	<dc:contributor xml:lang="en-US">Cancer Chemoprevention Research Center</dc:contributor>
	<dc:date>2018-02-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US"></dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ijcc.chemoprev.org/index.php/ijcc/article/view/199</dc:identifier>
	<dc:identifier>10.14499/indonesianjcanchemoprev9iss1pp16-22</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Cancer Chemoprevention; Vol 9, No 1 (2018); 16-22</dc:source>
	<dc:source>2355-8989</dc:source>
	<dc:source>2088-0197</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ijcc.chemoprev.org/index.php/ijcc/article/view/199/155</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2018 Dhania Novitasari, Sri Handayani, Riris Istighfari Jenie</dc:rights>
</oai_dc:dc>