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Cytotoxic Test of Cassia alata L. Leaves Ethanol Extracts, Fractions, and Main Compounds against MCF-7 Cells

Indonesian Journal of Cancer Chemoprevention · Vol. 13 No. 3 (2022) · hlm. 144–151

DOI
10.14499/indonesianjcanchemoprev13iss3pp144-151
ISSN
2355-8989, 2088-0197
Terbit
2022-10-31
Penerbit
Indonesian Society for Cancer Chemoprevention
Bahasa
eng

Abstrak

Cancer is the primary cause of death worldwide. Conventional cancer treatment is known to be less than optimal because of its chemoresistance and toxicity to normal cells. The search for cancer drugs from natural ingredients is still being carried out as an effort to overcome these problems. Cassia alata L. leaf extract is known to have antibacterial and antitumor activities. The main compounds of C. alata L. leaves (emodin, aloe-emodin, and kaempferol) have been reported to have antiproliferative activity. This study aimed to examine the cytotoxic activity of the C. alata L. leaves ethanol extracts, fractions, and main compounds against breast cancer cells (MCF-7). Cytotoxic activity was carried out by the MTT method. IC50 was determined by linear regression analysis describing the relationship between concentration and % cell viability. The results showed that aloe-emodin, emodin, and kaempferol had better cytotoxic activity than the extract and fractions of the C. alata L. leaves with IC50 values respectively 12.7 ppm, 18.1 ppm, and 131.3 ppm.Keywords: Breast cancer, cytotoxic assay, Cassia alata L., ketepeng cina, MCF-7.

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Sumber metadata: OAI-PMH (metadata jurnal) https://ijcc.chemoprev.org/index.php/ijcc/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Cytotoxic Test of Cassia alata L. Leaves Ethanol Extracts, Fractions, and Main Compounds against MCF-7 Cells</dc:title>
	<dc:creator>Khoerunisah, Marya Salfia</dc:creator>
	<dc:creator>Angelina, Marissa</dc:creator>
	<dc:creator>Kasiyati, Kasiyati</dc:creator>
	<dc:description xml:lang="en-US">Cancer is the primary cause of death worldwide. Conventional cancer treatment is known to be less than optimal because of its chemoresistance and toxicity to normal cells. The search for cancer drugs from natural ingredients is still being carried out as an effort to overcome these problems. Cassia alata L. leaf extract is known to have antibacterial and antitumor activities. The main compounds of C. alata L. leaves (emodin, aloe-emodin, and kaempferol) have been reported to have antiproliferative activity. This study aimed to examine the cytotoxic activity of the C. alata L. leaves ethanol extracts, fractions, and main compounds against breast cancer cells (MCF-7). Cytotoxic activity was carried out by the MTT method. IC50 was determined by linear regression analysis describing the relationship between concentration and % cell viability. The results showed that aloe-emodin, emodin, and kaempferol had better cytotoxic activity than the extract and fractions of the C. alata L. leaves with IC50 values respectively 12.7 ppm, 18.1 ppm, and 131.3 ppm.Keywords: Breast cancer, cytotoxic assay, Cassia alata L., ketepeng cina, MCF-7.</dc:description>
	<dc:publisher xml:lang="en-US">Indonesian Society for Cancer Chemoprevention</dc:publisher>
	<dc:contributor xml:lang="en-US">National Research and Innovation Agency of Indonesia</dc:contributor>
	<dc:contributor xml:lang="en-US">Diponegoro University, Departmen of Biology</dc:contributor>
	<dc:date>2022-10-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US"></dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ijcc.chemoprev.org/index.php/ijcc/article/view/417</dc:identifier>
	<dc:identifier>10.14499/indonesianjcanchemoprev13iss3pp144-151</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Cancer Chemoprevention; Vol 13, No 3 (2022); 144-151</dc:source>
	<dc:source>2355-8989</dc:source>
	<dc:source>2088-0197</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ijcc.chemoprev.org/index.php/ijcc/article/view/417/264</dc:relation>
	<dc:relation>https://ijcc.chemoprev.org/index.php/ijcc/article/downloadSuppFile/417/37</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2022 Indonesian Journal of Cancer Chemoprevention</dc:rights>
</oai_dc:dc>