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Molecular Review Covid19 from the Pathogenesis and Transmission Aspect

JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) · Vol. 12 No. 1si (2020) · hlm. 93–103

DOI
10.20473/jkl.v12i1si.2020.93-103
ISSN
2540-881X, 1829-7285
Terbit
2020-09-30
Penerbit
Universitas Airlangga
Bahasa
eng

Abstrak

Introduction: Corona disease-19 virus (COVID-19) spread and caused a pandemic that affected people all over the world. COVID-19 is also called Severe Acute Respiratory Syndrome-Coronavirus Disease (SARS-CoV). Discussion: COVID-19 is a β-coronavirus serotype which is a single strain of RNA virus and was an outbreak in 2002 (SARS-CoV) and 2012 (MERS-CoV). COVID-19 has Open Reading Frames (ORFs) consisting of Spikes (S), Envelopes (E), Membranes (M), and Nucleocapsids (N) with S parts being a glycoprotein that can attach to receptors owned by host cells, the receptors are CD 26, ACE-2, Ezrin, and Cyclophilins with the main receptor being ACE-2 in the lung organs. Process would evoke a host body's immune response consisting of natural and adaptive immune systems, involving the Antigen Presenting Cell (APC) system which consists of two, namely: Major Histocompatibility Complex (MHC) class I and II. APC could also generate adaptive immune system, consists of B and T cells. COVID-19 had the ability to survive in B and T cells, so that cytokine-chemokine secretion continues to be known as cytokine storm that trigger Acute Respiratory Distress Syndrome (ARDS) and death. Conclusion: The recovery prognosis of COVID-19 depended on the detection of COVID-19 patients because it was related to the severity of ARDS, so the earlier it was detected, the greater the chance of recovery.

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  • Universitas Airlangga
  • Sultan Agung Islamic University
  • Universitas Bhayangkara Surabaya
  • State University of Jakarta
  • Ministry of Health, Community Development, Gender, Elderly and Children
  • University of Nusa Cendana
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Rekan penulisOrganisasiArtikel bersama
Lucia Tri SuwantiUniversitas Airlangga2
Eduardus Bimo AksonoUniversitas Airlangga2
Sri Pantja MadyawatiUniversitas Airlangga2
Pudji SriantoUniversitas Airlangga2
Seagames WaluyoAfiliasi tidak diketahui2
Erma SafitriUniversitas Airlangga2
Epy Muhammad LuqmanUniversitas Airlangga2
Tri Wahyu SuprayogiUniversitas Airlangga2
Tita Damayanti LestariUniversitas Airlangga2
Dicky Mohammad DikmanUniversitas Airlangga2
Simon Martin Manyanza NzilibiliMinistry of Health, Community Development, Gender, Elderly and Children2
Anis IrmawatiUniversitas Airlangga1
Ni Luh Putu Ayu WardhaniUniversitas Airlangga1
Theresia Indah Budhy SUniversitas Airlangga1
Fransiskus AndriantoUniversitas Airlangga1
Ester Arijani RachmatUniversitas Airlangga1
Agniz Nur AuliaUniversitas Airlangga1
Intan NirwanaUniversitas Airlangga1
Fatma Yasmin MahdaniUniversitas Airlangga1
Eha Renwi AstutiUniversitas Airlangga1
Niluh Ringga WoroprobosariSultan Agung Islamic University1
Titiek BerniyantiUniversitas Airlangga1
Hari WibowoUniversitas Airlangga1
Agung SosiawanUniversitas Airlangga1
Dian Agustin WahjuningrumUniversitas Airlangga1
Vera Rimbawani SushantyUniversitas Bhayangkara Surabaya1
NovitasariAfiliasi tidak diketahui1
Muktiningsih NurjayadiState University of Jakarta1
Vira SaamiaUniversitas Airlangga1
Julianty AlmetUniversitas Airlangga1
Annytha Ina Rohi DethaUniversity of Nusa Cendana1
Ryanka EdilaUniversitas Airlangga1
Jose M. ObedencioAfiliasi tidak diketahui1
Mufasirin MufasirinUniversitas Airlangga1
Muchammad YunusUniversitas Airlangga1
Sesa Puput FebriyantiUniversitas Airlangga1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/JKL/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Molecular Review Covid19 from the Pathogenesis and Transmission Aspect</dc:title>
	<dc:creator>Setiawan, Fery</dc:creator>
	<dc:creator>Puspitasari, Heni</dc:creator>
	<dc:creator>Sunariani, Jenny</dc:creator>
	<dc:creator>Yudianto, Ahmad</dc:creator>
	<dc:subject xml:lang="en-US">Corona serotype β virus infection</dc:subject>
	<dc:subject xml:lang="en-US">SARS-MERS</dc:subject>
	<dc:subject xml:lang="en-US">ACE2-CD26</dc:subject>
	<dc:subject xml:lang="en-US">cytokines-chemokines</dc:subject>
	<dc:subject xml:lang="en-US">ARDS</dc:subject>
	<dc:description xml:lang="en-US">Introduction: Corona disease-19 virus (COVID-19) spread and caused a pandemic that affected people all over the world. COVID-19 is also called Severe Acute Respiratory Syndrome-Coronavirus Disease (SARS-CoV). Discussion: COVID-19 is a β-coronavirus serotype which is a single strain of RNA virus and was an outbreak in 2002 (SARS-CoV) and 2012 (MERS-CoV). COVID-19 has Open Reading Frames (ORFs) consisting of Spikes (S), Envelopes (E), Membranes (M), and Nucleocapsids (N) with S parts being a glycoprotein that can attach to receptors owned by host cells, the receptors are CD 26, ACE-2, Ezrin, and Cyclophilins with the main receptor being ACE-2 in the lung organs. Process would evoke a host body's immune response consisting of natural and adaptive immune systems, involving the Antigen Presenting Cell (APC) system which consists of two, namely: Major Histocompatibility Complex (MHC) class I and II. APC could also generate adaptive immune system, consists of B and T cells. COVID-19 had the ability to survive in B and T cells, so that cytokine-chemokine secretion continues to be known as cytokine storm that trigger Acute Respiratory Distress Syndrome (ARDS) and death. Conclusion: The recovery prognosis of COVID-19 depended on the detection of COVID-19 patients because it was related to the severity of ARDS, so the earlier it was detected, the greater the chance of recovery.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Airlangga</dc:publisher>
	<dc:date>2020-09-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/JKL/article/view/20469</dc:identifier>
	<dc:identifier>10.20473/jkl.v12i1si.2020.93-103</dc:identifier>
	<dc:source xml:lang="en-US">JURNAL KESEHATAN LINGKUNGAN ; Vol. 12 No. 1si (2020): SPECIAL ISSUE; 93-103</dc:source>
	<dc:source>2540-881X</dc:source>
	<dc:source>1829-7285</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/JKL/article/view/20469/12273</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2020 JURNAL KESEHATAN LINGKUNGAN</dc:rights>
</oai_dc:dc>