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Subclinical Renal Dysfunction in Horticultural Farmers: Early Detection in High Pesticide Exposure Areas

JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) · Vol. 17 No. 4 (2025) · hlm. 379–388

DOI
10.20473/jkl.v17i4.2025.379-388
ISSN
2540-881X, 1829-7285
Terbit
2025-10-27
Penerbit
Universitas Airlangga
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc-sa/4.0

Abstrak

Introduction: Globally, Chronic Kidney Disease of Unknown etiology (CKDu) poses a growing medical and social challenge, particularly in agrarian countries with a high prevalence of pesticide exposure. Indonesia, is one of the countries with a dominant agricultural sector. Tanjungsari and Glonggong villages in Wanasari subdistrict, Brebes Regency, are agricultural areas with a high intensity of pesticide use. Methods: This research aimed to identify the prevalence of subclinical renal dysfunction and associated risk factors in horticultural farmers in areas with high pesticide exposure. This research applied a cross-sectional method involving 40 farmers aged 26-65 years from two villages in Wanasari District, Brebes Regency. Data collection was carried out through interviews, and examination of kidney function biomarkers (serum creatinine and eGFR). Statistical analysis was conducted using Logistic Regression tests. Results and Discussion: The study revealed that 37.5% of participants exhibited eGFR values 20 years (p=0.024; OR=6.000; 95% CI:1.263-28.498) and daily working hours >6 hours (p<0.001; OR=69.279; 95% CI:6.423-756.965) showed a significant association with reduced eGFR values. Occupational health interventions should prioritize managing the duration and intensity of exposure to hazardous substances in the workplace, regardless of the workers' gender. Conclusion: The conclusion is that the daily working hours and the employment duration of the farmers are significantly associated with impaired kidney function, potentially acting as an initial marker of CKDu.

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  • Tanjungpura University
  • Universitas Gadjah Mada
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Yusniar Hanani DarundiatiAfiliasi tidak diketahui4
Mateus Sakundarno AdiAfiliasi tidak diketahui3
Onny SetianiAfiliasi tidak diketahui3
Liena SofianaAfiliasi tidak diketahui2
Martini MartiniAfiliasi tidak diketahui2
Bagoes WidjanarkoAfiliasi tidak diketahui2
Sulistiyani SulistiyaniAfiliasi tidak diketahui2
NurjazuliAfiliasi tidak diketahui2
SulistiyaniAfiliasi tidak diketahui2
Farid AgushybanaAfiliasi tidak diketahui1
Wida Ayulia DamayantiAfiliasi tidak diketahui1
Evi WidowatiAfiliasi tidak diketahui1
Alfiana Ainun NisaAfiliasi tidak diketahui1
Rafidha Nur AlifahAfiliasi tidak diketahui1
Della Rizky FitrianaAfiliasi tidak diketahui1
Luvi Lia NursucilowatiAfiliasi tidak diketahui1
Edi KurniawanAfiliasi tidak diketahui1
Tri RamadhaniAfiliasi tidak diketahui1
Risna Endah BudiatiAfiliasi tidak diketahui1
Suharyo HadisaputroAfiliasi tidak diketahui1
Rr. Anggun Paramita DjatiAfiliasi tidak diketahui1
Zahroh ShaluhiyahAfiliasi tidak diketahui1
Lily KresnowatiAfiliasi tidak diketahui1
Ferry HadaryTanjungpura University1
Sri RezekiAfiliasi tidak diketahui1
Sri Utari Shinta DewiAfiliasi tidak diketahui1
Darul Giring AlanaAfiliasi tidak diketahui1
Adith AninditoAfiliasi tidak diketahui1
Supi YuliantoAfiliasi tidak diketahui1
Desisius GumilarAfiliasi tidak diketahui1
Lisa Astridni PutriAfiliasi tidak diketahui1
Dwiko Budi PermadiUniversitas Gadjah Mada1
SanudinAfiliasi tidak diketahui1
Mohammad Zen RahfiludinAfiliasi tidak diketahui1
Apoina KartiniAfiliasi tidak diketahui1
Novia LuthviatinAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/JKL/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Subclinical Renal Dysfunction in Horticultural Farmers: Early Detection in High Pesticide Exposure Areas</dc:title>
	<dc:creator>Hansen</dc:creator>
	<dc:creator>Mursid Raharjo</dc:creator>
	<dc:creator>Suhartono</dc:creator>
	<dc:creator>Nur Endah Wahyuningsih</dc:creator>
	<dc:subject xml:lang="en-US">Agricultural Workers</dc:subject>
	<dc:subject xml:lang="en-US">Indonesia</dc:subject>
	<dc:subject xml:lang="en-US">Pesticide Exposure</dc:subject>
	<dc:subject xml:lang="en-US">Renal Dysfunction</dc:subject>
	<dc:description xml:lang="en-US">Introduction: Globally, Chronic Kidney Disease of Unknown etiology (CKDu) poses a growing medical and social challenge, particularly in agrarian countries with a high prevalence of pesticide exposure. Indonesia, is one of the countries with a dominant agricultural sector. Tanjungsari and Glonggong villages in Wanasari subdistrict, Brebes Regency, are agricultural areas with a high intensity of pesticide use. Methods: This research aimed to identify the prevalence of subclinical renal dysfunction and associated risk factors in horticultural farmers in areas with high pesticide exposure. This research applied a cross-sectional method involving 40 farmers aged 26-65 years from two villages in Wanasari District, Brebes Regency. Data collection was carried out through interviews, and examination of kidney function biomarkers (serum creatinine and eGFR). Statistical analysis was conducted using Logistic Regression tests. Results and Discussion: The study revealed that 37.5% of participants exhibited eGFR values &amp;lt;90 ml/min/1.73 m2, indicating subclinical impairment of kidney function. Employment duration &amp;gt;20 years (p=0.024; OR=6.000; 95% CI:1.263-28.498) and daily working hours &amp;gt;6 hours (p&amp;lt;0.001; OR=69.279; 95% CI:6.423-756.965) showed a significant association with reduced eGFR values. Occupational health interventions should prioritize managing the duration and intensity of exposure to hazardous substances in the workplace, regardless of the workers' gender. Conclusion: The conclusion is that the daily working hours and the employment duration of the farmers are significantly associated with impaired kidney function, potentially acting as an initial marker of CKDu.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Airlangga</dc:publisher>
	<dc:date>2025-10-27</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:format>text/xml</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/JKL/article/view/77941</dc:identifier>
	<dc:identifier>10.20473/jkl.v17i4.2025.379-388</dc:identifier>
	<dc:source xml:lang="en-US">JURNAL KESEHATAN LINGKUNGAN ; Vol. 17 No. 4 (2025): JURNAL KESEHATAN LINGKUNGAN; 379-388</dc:source>
	<dc:source>2540-881X</dc:source>
	<dc:source>1829-7285</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/JKL/article/view/77941/34363</dc:relation>
	<dc:relation>https://e-journal.unair.ac.id/JKL/article/view/77941/34493</dc:relation>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-nc-sa/4.0</dc:rights>
</oai_dc:dc>