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Attenuation Effects of Time-Restricted Feeding Initiated Prior to and During Benzene Exposure on Leukocyte Profiles in Rats: A Preliminary Study

JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) · Vol. 18 No. 4 (2026) · hlm. 355–365

DOI
10.20473/jkl.v18i4.2026.355-365
ISSN
2540-881X, 1829-7285
Terbit
2026-10-18
Penerbit
Universitas Airlangga
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc-sa/4.0

Abstrak

Introduction: Benzene exposure is a major cause of hematotoxicity, which can trigger leukopenia and immunosuppression through oxidative stress. This study aimed to analyze and compare the attenuation effect of Time-Restricted Feeding (TRF) with different durations (12 and 8-hours) initiated prior to and during benzene exposure on the total white blood cell (TWBC) count and differential WBC count profile in Wistar rat. Methods: This was a purely experimental study, involving 28 rats which were divided randomly into 4 groups (KN fed ad libitum without benzene exposure; K0 fed ad libitum and exposed to 300 ppm benzene; X1 12-hour TRF and exposed to 300 ppm benzene; X2 8-hour TRF and exposed to 300 ppm benzene). TWBC and differential WBC count profiles were calculated using an automated hematology analyzer. Results and Discussion: Exposure to 300 ppm benzene vapor in K0 significantly decreased TWBC and absolute lymphocyte counts compared to KN. TWBC in groups X1 and X2 were within the normal range and significantly higher than in K0. Group X2 showed a significant increase in absolute neutrophil counts compared to K0, which is suspected to be an indication of starvation stress due to the longer fasting window. Conclusions: 12 or 8-hour TRF initiated prior to and during benzene exposure, successfully attenuated the decrease in TWBC and lymphocyte counts caused by benzene exposure. There were no significant differences in all WBC parameters between 12 and 8-hour TRF. Further research with oxidative stress biomarker measurements is needed to validate the cellular mechanism of TRF's attenuating effect.

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  • Universiti Putra Malaysia
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  • Ministry of Health and Social Welfare
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Rekan penulisOrganisasiArtikel bersama
Khuliyah Candraning DiyanahUniversitas Airlangga4
Ririh YudhastutiUniversitas Airlangga4
Kuntoro KuntoroUniversitas Airlangga3
Aditya Sukma PawitraUniversitas Airlangga3
Rahmat DapariUniversiti Putra Malaysia3
Muhammad Rasyid RidhaLambung Mangkurat University3
Diva Alishya ShafwahUniversitas Airlangga3
Babucarr JasseyMinistry of Health and Social Welfare3
Nafi'atul IrbahUniversitas Airlangga3
Rachmah IndawatiUniversitas Airlangga2
Farapti FaraptiUniversitas Airlangga2
Chatarina Umbul WahyuniUniversitas Airlangga2
R. AzizahUniversitas Airlangga2
Corie Indria PrasastiUniversitas Airlangga2
Juliana Binti JalaludinDiponegoro University2
Soedjajadi KemanUniversitas Airlangga2
Dwi - KuswantoUniversitas Airlangga1
Annisaa Wulida FurqoniaUniversitas Airlangga1
Diah RatnadewiIPB University1
Atik Choirul HidajahUniversitas Airlangga1
Ika Dewi AnaUniversitas Gadjah Mada1
Christofora Hanny WidjajaIPB University1
Anggraini BarlianBandung Institute of Technology1
Rizka Musdalifah AmsarBandung Institute of Technology1
Triati Dewi Kencana WunguBandung Institute of Technology1
Fedik Abdul RantamUniversitas Airlangga1
Romaniyanto RomaniyantoRSO Soeharso Surakarta1
Cita Rosita Sigit PrakoeswaUniversitas Airlangga1
Damayanti TinduhAfiliasi tidak diketahui1
Dwikora Novembri UtomoUniversitas Airlangga1
Heri SurotoUniversitas Airlangga1
Ferdiansyah FerdiansyahUniversitas Airlangga1
Mochammad Bagus QomaruddinUniversitas Airlangga1
Apik Indarty MoedjionoHasanuddin University1
Nursalam NursalamUniversitas Airlangga1
Fery Agusman Motuho MendrofaUniversitas Karya Husada Semarang1

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Sumber metadata: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/JKL/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Attenuation Effects of Time-Restricted Feeding Initiated Prior to and During Benzene Exposure on Leukocyte Profiles in Rats: A Preliminary Study</dc:title>
	<dc:creator>Reny Indrayani</dc:creator>
	<dc:creator>Lilis Sulistyorini</dc:creator>
	<dc:creator>Hari Basuki Notobroto</dc:creator>
	<dc:creator>I Ketut Sudiana</dc:creator>
	<dc:subject xml:lang="en-US">Benzene</dc:subject>
	<dc:subject xml:lang="en-US">Good Health</dc:subject>
	<dc:subject xml:lang="en-US">Hematotoxicity</dc:subject>
	<dc:subject xml:lang="en-US">Intermittent Fasting</dc:subject>
	<dc:subject xml:lang="en-US">WBC</dc:subject>
	<dc:description xml:lang="en-US">Introduction: Benzene exposure is a major cause of hematotoxicity, which can trigger leukopenia and immunosuppression through oxidative stress. This study aimed to analyze and compare the attenuation effect of Time-Restricted Feeding (TRF) with different durations (12 and 8-hours) initiated prior to and during benzene exposure on the total white blood cell (TWBC) count and differential WBC count profile in Wistar rat. Methods: This was a purely experimental study, involving 28 rats which were divided randomly into 4 groups (KN fed ad libitum without benzene exposure; K0 fed ad libitum and exposed to 300 ppm benzene; X1 12-hour TRF and exposed to 300 ppm benzene; X2 8-hour TRF and exposed to 300 ppm benzene). TWBC and differential WBC count profiles were calculated using an automated hematology analyzer. Results and Discussion: Exposure to 300 ppm benzene vapor in K0 significantly decreased TWBC and absolute lymphocyte counts compared to KN. TWBC in groups X1 and X2 were within the normal range and significantly higher than in K0. Group X2 showed a significant increase in absolute neutrophil counts compared to K0, which is suspected to be an indication of starvation stress due to the longer fasting window. Conclusions: 12 or 8-hour TRF initiated prior to and during benzene exposure, successfully attenuated the decrease in TWBC and lymphocyte counts caused by benzene exposure. There were no significant differences in all WBC parameters between 12 and 8-hour TRF. Further research with oxidative stress biomarker measurements is needed to validate the cellular mechanism of TRF's attenuating effect.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Airlangga</dc:publisher>
	<dc:date>2026-10-18</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:format>text/xml</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/JKL/article/view/94568</dc:identifier>
	<dc:identifier>10.20473/jkl.v18i4.2026.355-365</dc:identifier>
	<dc:source xml:lang="en-US">JURNAL KESEHATAN LINGKUNGAN ; Vol. 18 No. 4 (2026): JURNAL KESEHATAN LINGKUNGAN ; 355-365</dc:source>
	<dc:source>2540-881X</dc:source>
	<dc:source>1829-7285</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/JKL/article/view/94568/41533</dc:relation>
	<dc:relation>https://e-journal.unair.ac.id/JKL/article/view/94568/41569</dc:relation>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-nc-sa/4.0</dc:rights>
</oai_dc:dc>