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Effectivity of lime leaves (Citrus sp.) in inhibiting Escherichia coli: a meta-analysis

JITRO (Jurnal Ilmu dan Teknologi Peternakan Tropis) · Vol. 10 No. 1 (2023) · pp. 39–47

DOI
10.33772/jitro.v10i1.27464
ISSN
2406-9337
Published
2023-01-31
Publisher
Universitas Halu Oleo
Language
eng
License
creativecommons.org/licenses/by-sa/4.0

Abstract

Antibiotics Growth Promoter (AGP) are currently banned. Citrus leaves have active secondary metabolites that have the potential to be used as phytogenic feed additives. Many in vitro studies have reported the activity of lime leaves against E coli. Therefore, this study aims to integrate various studies in order to obtain comprehensive information on the activity of lime leaves against E coli with a meta-analysis. This research was conducted by collecting studies of citrus leaves from various species, origin, extraction methods, and different antibacterial test methods and comparing the treatment of citrus leaves with controls in inhibiting E coli by looking at the diameter of the inhibition zone. The results showed that kaffir lime leaves as an alternative phytogenic feed additive for AGP were effective in inhibiting E. coli. The inhibitory ability of E. coli bacteria was based on differences in the origin of lime leaves and extraction methods, while differences in levels, types of lime leaves, and antibacterial test methods did not affect the inhibition of E. coli. Citrus leaf extract at a low concentration of 5 mg/ml was able to inhibit E coli bacteria. Keywords: escherichia coli, lime leaf, meta-analysis

Collaboration network of the authors

16 authors · 40 co-authorship links

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

  • IPB University
  • Syarif Hidayatullah State Islamic University Jakarta
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Nahrowi NahrowiAffiliation unknown1
Muhammad RidlaAffiliation unknown1
Rima Shidqiyya Hidayati MartinAffiliation unknown1
Nurmaya Rahmawati MuisAffiliation unknown1
Pudji MuljonoIPB University1
Nahri IdrisAffiliation unknown1
Retno Sri Hartati MulyandariAffiliation unknown1
Ahmad SofyanSyarif Hidayatullah State Islamic University Jakarta1
Sadarman SadarmanAffiliation unknown1
Novia QomariyahAffiliation unknown1
Zulkarnain ZulkarnainAffiliation unknown1
Tri Rachmanto PrihambodoAffiliation unknown1
Erika Budiarti LaconiAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://ojs.uho.ac.id/index.php/peternakan-tropis/oai, first harvested 29 Okt 2026, last seen 29 Okt 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">Effectivity of lime leaves (Citrus sp.) in inhibiting Escherichia coli: a meta-analysis</dc:title>
	<dc:creator>Rohmah, Aenyfatchu</dc:creator>
	<dc:creator>Retnani, Yuli</dc:creator>
	<dc:creator>Jayanegara, Anuraga</dc:creator>
	<dc:description xml:lang="en-US">Antibiotics Growth Promoter (AGP) are currently banned. Citrus leaves have active secondary metabolites that have the potential to be used as phytogenic feed additives. Many in vitro studies have reported the activity of lime leaves against E coli. Therefore, this study aims to integrate various studies in order to obtain comprehensive information on the activity of lime leaves against E coli with a meta-analysis. This research was conducted by collecting studies of citrus leaves from various species, origin, extraction methods, and different antibacterial test methods and comparing the treatment of citrus leaves with controls in inhibiting E coli by looking at the diameter of the inhibition zone. The results showed that kaffir lime leaves as an alternative phytogenic feed additive for AGP were effective in inhibiting E. coli. The inhibitory ability of E. coli bacteria was based on differences in the origin of lime leaves and extraction methods, while differences in levels, types of lime leaves, and antibacterial test methods did not affect the inhibition of E. coli. Citrus leaf extract at a low concentration of 5 mg/ml was able to inhibit E coli bacteria.

Keywords:  escherichia coli, lime leaf, meta-analysis</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Halu Oleo</dc:publisher>
	<dc:contributor xml:lang="en-US">Department of Nutrition and Feed Technology, Faculty of Animal Science, IPB University</dc:contributor>
	<dc:date>2023-01-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ojs.uho.ac.id/index.php/peternakan-tropis/article/view/27464</dc:identifier>
	<dc:identifier>10.33772/jitro.v10i1.27464</dc:identifier>
	<dc:source xml:lang="en-US">Jurnal Ilmu dan Teknologi Peternakan Tropis; Vol 10, No 1 (2023): JITRO, January 2023; 39-47</dc:source>
	<dc:source>2406-9337</dc:source>
	<dc:source>10.33772/jitro.v10i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ojs.uho.ac.id/index.php/peternakan-tropis/article/view/27464/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2023 Jurnal Ilmu dan Teknologi Peternakan Tropis</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-sa/4.0</dc:rights>
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