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Use of Propolis Extract as an Ingredient for Skin Cancer Cell Apoptosis Transfersome Cream with Gelatin as an Emulgator

JITRO (Jurnal Ilmu dan Teknologi Peternakan Tropis) · Vol. 10 No. 1 (2023) · pp. 245–250

DOI
10.33772/jitro.v10i1.28659
ISSN
2406-9337
Published
2023-01-31
Publisher
Universitas Halu Oleo
Language
eng
License
creativecommons.org/licenses/by-sa/4.0

Abstract

Transfersome has been commonly used to increase the penetration of drugs derived from natural ingredients. Propolis is a natural ingredient with many benefits, such as antimicrobial, antiviral, anti-inflammatory, antitumor, antioxidant, and anticancer. In various in vitro studies, propolis showed proapoptotic activity in cancer cells. Gelatin is a chemical compound that can be used as an emulsifier because it has a hydrophobic part in the peptide chain. This study aimed to determine the optimal gelatin content based on physical tests as an emulsifier in the manufacture of emulsions for transfersome cream ingredients. The research method used was an experimental laboratory with 6 gelatin concentration treatments, namely 1% (P1), 2% (P2), 3% (P3), 4% (P4), 5% (P5), and 6% (P6) with 3 replicates. To make the emulsion, 5% propolis extract was added. The results of statistical analysis showed that the manufacture of emulsions using different concentrations of gelatin had a very significant effect (p

Collaboration network of the authors

40 authors · 87 co-authorship links · 16 across different organisations · showing the 40 most connected

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

  • Universitas Halu Oleo
  • Institut Agama Islam Negeri Kendari
  • Universitas Muhammadiyah Parepare
  • Jenderal Soedirman University
  • Universitas Islam Negeri Mahmud Yunus Batusangkar
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Jopang JopangUniversitas Halu Oleo3
Akhyar AbdullahUniversitas Halu Oleo3
Kuswati KuswatiAffiliation unknown2
Makmur KambolongUniversitas Halu Oleo2
Mustakim MustakimUniversitas Muhammadiyah Parepare2
Erni QomariyahAffiliation unknown2
Putery PermatasariAffiliation unknown1
Khothibul Umam Al AwwalyAffiliation unknown1
Madiyan SugestiAffiliation unknown1
Shintia Sukmawati Cahya MaulidAffiliation unknown1
Didiek PurwantoAffiliation unknown1
Sumardona SumardonaInstitut Agama Islam Negeri Kendari1
Sarlinda SarlindaInstitut Agama Islam Negeri Kendari1
Epiyana EpiyanaInstitut Agama Islam Negeri Kendari1
Sarnianti SarniantiInstitut Agama Islam Negeri Kendari1
Kamrin KamrinUniversitas Halu Oleo1
Ruslan MajidUniversitas Halu Oleo1
Megasari SidulaAffiliation unknown1
Nooraini AsrudinAffiliation unknown1
Suriyani Bunga BataraAffiliation unknown1
Siti NurhayatiJenderal Soedirman University1
Nyoman Ningsih UtamiAffiliation unknown1
Candra Puspita NingtyasAffiliation unknown1
Aprilia WulandariAffiliation unknown1
Santi M Santi MAffiliation unknown1
isran museAffiliation unknown1
Aminuddin AminuddinInstitut Agama Islam Negeri Kendari1
Dewi DewiAffiliation unknown1
Muh AmirUniversitas Halu Oleo1
muslima kurniatiAffiliation unknown1
Abdul KadirUniversitas Halu Oleo1
Mirab MirabAffiliation unknown1
Irwan IrwanUniversitas Islam Negeri Mahmud Yunus Batusangkar1
Yuliana Yunus YunusAffiliation unknown1
marni susantiAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://ojs.uho.ac.id/index.php/peternakan-tropis/oai, first harvested 29 Okt 2026, last seen 1 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">Use of Propolis Extract as an Ingredient for Skin Cancer Cell Apoptosis Transfersome Cream with Gelatin as an Emulgator</dc:title>
	<dc:creator>Puspa, Galuh Wilujeng</dc:creator>
	<dc:creator>Susilo, Agus</dc:creator>
	<dc:creator>Cahyati, Miftakhul</dc:creator>
	<dc:creator>Nurjannah, Nurjannah</dc:creator>
	<dc:creator>Pranowo, Dodyk</dc:creator>
	<dc:description xml:lang="en-US">Transfersome has been commonly used to increase the penetration of drugs derived from natural ingredients.  Propolis is a natural ingredient with many benefits, such as antimicrobial, antiviral, anti-inflammatory, antitumor, antioxidant, and anticancer. In various in vitro studies, propolis showed proapoptotic activity in cancer cells. Gelatin is a chemical compound that can be used as an emulsifier because it has a hydrophobic part in the peptide chain. This study aimed to determine the optimal gelatin content based on physical tests as an emulsifier in the manufacture of emulsions for transfersome cream ingredients. The research method used was an experimental laboratory with 6 gelatin concentration treatments, namely 1% (P1), 2% (P2), 3% (P3), 4% (P4), 5% (P5), and 6% (P6) with 3 replicates. To make the emulsion, 5% propolis extract was added. The results of statistical analysis showed that the manufacture of emulsions using different concentrations of gelatin had a very significant effect (p</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Halu Oleo</dc:publisher>
	<dc:contributor xml:lang="en-US">Universitas Brawijaya through the 2022 LPPM Strategic Research Fund Grant activity with contract number 1665.34/UN.01/UB/2022 which has provided funding and facilities for this research.</dc:contributor>
	<dc:date>2023-01-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ojs.uho.ac.id/index.php/peternakan-tropis/article/view/28659</dc:identifier>
	<dc:identifier>10.33772/jitro.v10i1.28659</dc:identifier>
	<dc:source xml:lang="en-US">Jurnal Ilmu dan Teknologi Peternakan Tropis; Vol 10, No 1 (2023): JITRO, January 2023; 245-250</dc:source>
	<dc:source>2406-9337</dc:source>
	<dc:source>10.33772/jitro.v10i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ojs.uho.ac.id/index.php/peternakan-tropis/article/view/28659/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2023 Jurnal Ilmu dan Teknologi Peternakan Tropis</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-sa/4.0</dc:rights>
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