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Vitamin D Levels in Patients with Endometriosis Cysts

Journal of Biomedicine and Translational Research · Vol. 11 No. 3 (2025) · hlm. 93–97

DOI
10.14710/jbtr.v11i3.29234
ISSN
2503-2178
Terbit
2025-12-24
Penerbit
Faculty of Medicine, Universitas Diponegoro
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-sa/4.0

Abstrak

Background: Endometriosis is associated with lipid peroxidation by reactive oxygen species (ROS) which causes endometrial cell DNA damage. Vitamin D is known to have good antioxidant content, so it is thought to have the ability to inhibit proliferation, invasion and production of pro-inflammatory cytokines in endometriosis.Objective: To analyze the differences in vitamin D levels between endometriosis cyst patients and normal women and the relationship between vitamin D levels and the size of endometriosis cysts.Methods: Analytical observational study with cross sectional design with 60 samples consisting of 30 endometriosis cyst patients and 30 normal women. Evaluation was carried out on vitamin 25 (OH) D serum levels using the ELISA method and endometriosis cyst size. Cyst size is evaluated by assessing the largest diameter of a single endometriosis cyst assessed through an ultrasound examination by a specialist doctor.Results: Vitamin D levels in the endometriosis group were significantly lower than normal women (13.23 ± 5.39 ng/mL vs 15.83 ± 5.30 ng/mL; p = 0.048). Subjects with vitamin D levels 13.45 ng/mL. There was no correlation between vitamin D levels and the size of endometriosis cysts (p=0.720).Conclusion: Endometriosis patients have significantly lower serum vitamin D levels than normal women (OR 4.03; CI95% 1.37-11.83). Serum vitamin D levels do not significantly correlate with endometriosis cyst size.

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  • Diponegoro University
  • Dr. Kariadi Hospital
  • Universitas Airlangga
  • Universitas Wahid Hasyim
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  • Organisasi sama
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Rekan penulisOrganisasiArtikel bersama
Sultana MH FaradzDiponegoro University2
Widjiati WidjiatiUniversitas Airlangga1
Oktoria IndraprajaDiponegoro University1
Noor Pramono NoerpramanaDiponegoro University1
Tri Indah WinarniDiponegoro University1
Fatinah ShahabUniversitas Wahid Hasyim1
Hary TjahjantoDiponegoro University1
Nurin Aisyiyah ListyasariDiponegoro University1
Ni Made Indri Dwi SusantiDiponegoro University1
Dik PuspasariDiponegoro University1
Noor PramonoDiponegoro University1
Julian DewantiningrumDiponegoro University1
Rabiah AdawiyahDiponegoro University1

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Sumber metadata: OAI-PMH (metadata jurnal) https://ejournal2.undip.ac.id/index.php/jbtr/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Vitamin D Levels in Patients with Endometriosis Cysts</dc:title>
	<dc:creator>Mustikarani, Rianti</dc:creator>
	<dc:creator>Mulyantoro, Inu</dc:creator>
	<dc:subject xml:lang="en-US">Endometriosis; Endometriosis cyst size; Vitamin D</dc:subject>
	<dc:description xml:lang="en-US">Background: Endometriosis is associated with lipid peroxidation by reactive oxygen species (ROS) which causes endometrial cell DNA damage. Vitamin D is known to have good antioxidant content, so it is thought to have the ability to inhibit proliferation, invasion and production of pro-inflammatory cytokines in endometriosis.Objective: To analyze the differences in vitamin D levels between endometriosis cyst patients and normal women and the relationship between vitamin D levels and the size of endometriosis cysts.Methods: Analytical observational study with cross sectional design with 60 samples consisting of 30 endometriosis cyst patients and 30 normal women. Evaluation was carried out on vitamin 25 (OH) D serum levels using the ELISA method and endometriosis cyst size. Cyst size is evaluated by assessing the largest diameter of a single endometriosis cyst assessed through an ultrasound examination by a specialist doctor.Results: Vitamin D levels in the endometriosis group were significantly lower than normal women (13.23 ± 5.39 ng/mL vs 15.83 ± 5.30 ng/mL; p = 0.048). Subjects with vitamin D levels &lt;13.45 had a 4.03x (OR 4.03; CI95% 1.37-11.83) higher risk of experiencing endometriosis compared to subjects with vitamin D levels &gt; 13.45 ng/mL. There was no correlation between vitamin D levels and the size of endometriosis cysts (p=0.720).Conclusion: Endometriosis patients have significantly lower serum vitamin D levels than normal women (OR 4.03; CI95% 1.37-11.83). Serum vitamin D levels do not significantly correlate with endometriosis cyst size.</dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Medicine, Universitas Diponegoro</dc:publisher>
	<dc:date>2025-12-24</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
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	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ejournal2.undip.ac.id/index.php/jbtr/article/view/29234</dc:identifier>
	<dc:identifier>10.14710/jbtr.v11i3.29234</dc:identifier>
	<dc:source xml:lang="en-US">Journal of Biomedicine and Translational Research; Vol 11, No 3 (2025): December 2025; 93-97</dc:source>
	<dc:source>2503-2178</dc:source>
	<dc:source>10.14710/jbtr.v11i3</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ejournal2.undip.ac.id/index.php/jbtr/article/view/29234/13564</dc:relation>
	<dc:relation>https://ejournal2.undip.ac.id/index.php/jbtr/article/downloadSuppFile/29234/7183</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2025 Journal of Biomedicine and Translational Research</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by-sa/4.0</dc:rights>
</oai_dc:dc>