Jurnal SINTA 1
The Difference of Integrin ανβ3 Expression, Leukemia Inhibitory Factors and Superoxide Dismutase Serum Concentration in the Provision of Kebar Extract (Biophytum petersianum Klotczh), Metformin, and Their Combination to Mouse models of Endometriosis
Journal of Biomedicine and Translational Research · Vol. 4 No. 1 (2018) · hlm. 1–8
- ISSN
- 2503-2178
- Terbit
- 2018-07-30
- Penerbit
- Faculty of Medicine, Universitas Diponegoro
- Bahasa
- eng
Abstrak
Background: In endometriosis there is a decrease in endometrial receptivity. Kebar and Metformin grasses are expected to improve the condition of endometrial receptivityObjective: To find out whether there is any effect of giving Kebar grass extract and metformin on endometrial receptivity Methods: The study was designed by using a simple experimental randomization. It was conducted in Obstetrics Gynecology Department - Faculty of Medicine Diponegoro University and Faculty of Veterinary Medicine Airlangga University. Sample calculation was employed. The study was done within five groups including control group with normal mice, group of endometriosis mouse models given placebo, group of endometriosis mouse models given Kebar grass extract, group of endometriosis mouse models given metformin, and group of endometriosis mouse models given the combination of Kebar grass – metformin extract. The examination materials of ανβ3 integrin and Leukemia Inhibitory Factors were taken from the uteri of the mice and measured by the Rammele Scale Index (Immuno Reactive Score), while the Superoxide Dismutase examination using ELISA was derived from mice serum. These examinations were performed by two veterinariansResults: The expression of ανβ3 integrin was significantly higher in the group of mouse models given Kebar grass extract as well as the combination of Kebar and metformin grass extracts (p <0.05) rather than in the group of endometriosis mouse models with no treatment, whereas LIF expression was significantly higher in the group given Kebar grass extract, metformin and combination of both extracts (p <0.05). Serum SOD levels remained the same.Conclusion: The expressions of ανβ3 Integrin and LIF are higher due to the provision of Kebar grass extract as well as the combination of Kebar grass and metformin extracts
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- Universitas Muhammadiyah Riau
- Diponegoro University
- Institut Agama Islam Negeri Kendari
- Universitas Islam Negeri Antasari Banjarmasin
- Lambung Mangkurat University
- University of Mataram
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| Rekan penulis | Organisasi | Artikel bersama |
|---|---|---|
| Erma Safitri | Afiliasi tidak diketahui | 2 |
| Noor Pramono | Afiliasi tidak diketahui | 2 |
| Yuli Trisetiyono | Afiliasi tidak diketahui | 2 |
| Mulyanto Mulyanto | Universitas Muhammadiyah Riau | 1 |
| Budi Utomo | Diponegoro University | 1 |
| Yudi Her Oktaviono | Afiliasi tidak diketahui | 1 |
| Romi Ermawan | Afiliasi tidak diketahui | 1 |
| Budi Susetyo Pikir | Afiliasi tidak diketahui | 1 |
| Inu Mulyantoro | Afiliasi tidak diketahui | 1 |
| Oktoria Indrapraja | Afiliasi tidak diketahui | 1 |
| Noor Pramono Noerpramana | Afiliasi tidak diketahui | 1 |
| Nur Rahman | Institut Agama Islam Negeri Kendari | 1 |
| Besari Adi Pramono | Afiliasi tidak diketahui | 1 |
| Raden Soerjo Hadijono | Afiliasi tidak diketahui | 1 |
| Agoes Oerip Poerwoko | Afiliasi tidak diketahui | 1 |
| Arufiadi Anityo Mochtar | Afiliasi tidak diketahui | 1 |
| Iwan Sahrial Hamid | Afiliasi tidak diketahui | 1 |
| Aditya Yudhana | Afiliasi tidak diketahui | 1 |
| Carolina Ardy | Afiliasi tidak diketahui | 1 |
| Widya Paramita Lokapirnasari | Afiliasi tidak diketahui | 1 |
| Suryo Kuncorojakti | Afiliasi tidak diketahui | 1 |
| Nusdianto Triakoso | Afiliasi tidak diketahui | 1 |
| Sherbrina Bai Seenivasa Rao | Afiliasi tidak diketahui | 1 |
| Annise Proboningrat | Afiliasi tidak diketahui | 1 |
| Rimayanti Rimayanti | Universitas Islam Negeri Antasari Banjarmasin | 1 |
| Viski Fitri Hendrawan | Afiliasi tidak diketahui | 1 |
| Tita Damayanti Lestari | Afiliasi tidak diketahui | 1 |
| Zahra Shabira | Afiliasi tidak diketahui | 1 |
| Maslichah Mafruchati | Afiliasi tidak diketahui | 1 |
| Budi Santoso | University of Mataram | 1 |
| Meitria Syahadatina Noor | Lambung Mangkurat University | 1 |
| H.M Bahkriansyah | Afiliasi tidak diketahui | 1 |
| Suherni Susilowati | Afiliasi tidak diketahui | 1 |
| Portia Sumarsono | Afiliasi tidak diketahui | 1 |
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