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Biochemical and Histopathological Effect of Combination Extract Ethanolic Turmeric (Curcuma longa) and Kalmegh (Andrographis paniculata) in Iron Overload Rat Model

Journal of Biomedicine and Translational Research · Vol. 12 No. 1 (2026) · hlm. 7–13

DOI
10.14710/jbtr.v12i1.28945
ISSN
2503-2178
Terbit
2026-04-30
Penerbit
Faculty of Medicine, Universitas Diponegoro
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-sa/4.0

Abstrak

Background: Thalassemia-β patients have erythrocyte damage that requires blood transfusion treatment. Blood transfusion treatment that is undergone has an impact on the condition of iron overload in the body. The condition of iron overload will result in oxidative stress and organ damage that requires additional therapyObjective: aimed to compare the effectiveness of turmeric and kalmegh extract doses against biochemical parameters and histopathological features of iron-induced liver Rattus Norvegicus.Methods: This study used a True-experiment research design with a post-test-only control group. A total of 30 rats were used and divided into six treatment groups, normal, deferiprone drugs, turmeric, and kalmegh extracts 100mg/KgBW, 200mg/KgBW, and 400mg/KgBW. Malondialdehyde, catalase, superoxide dismutase, and ferritin are used as biochemical parameters and hepatic histopathology is documented.Results: The results showed that there were significant improvements and differences in iron-induced rats.Conclusion: The study also showed that turmeric and kalmegh extracts had similar effects to deferiprone.

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Sumber metadata: OAI-PMH (metadata jurnal) https://ejournal2.undip.ac.id/index.php/jbtr/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Biochemical and Histopathological Effect of Combination Extract Ethanolic Turmeric (Curcuma longa) and Kalmegh (Andrographis paniculata) in Iron Overload Rat Model</dc:title>
	<dc:creator>Prastiyo, M. Dodik</dc:creator>
	<dc:creator>Rujito, Lantip</dc:creator>
	<dc:creator>Hernawati, Hernawati</dc:creator>
	<dc:subject xml:lang="en-US">Iron Overload;  Kalmegh; Oxidative stress; Thalassemia; Turmeric</dc:subject>
	<dc:description xml:lang="en-US">Background: Thalassemia-β patients have erythrocyte damage that requires blood transfusion treatment. Blood transfusion treatment that is undergone has an impact on the condition of iron overload in the body. The condition of iron overload will result in oxidative stress and organ damage that requires additional therapyObjective: aimed to compare the effectiveness of turmeric and kalmegh extract doses against biochemical parameters and histopathological features of iron-induced liver Rattus Norvegicus.Methods: This study used a True-experiment research design with a post-test-only control group. A total of 30 rats were used and divided into six treatment groups, normal, deferiprone drugs, turmeric, and kalmegh extracts 100mg/KgBW, 200mg/KgBW, and 400mg/KgBW. Malondialdehyde, catalase, superoxide dismutase, and ferritin are used as biochemical parameters and hepatic histopathology is documented.Results: The results showed that there were significant improvements and differences in iron-induced rats.Conclusion: The study also showed that turmeric and kalmegh extracts had similar effects to deferiprone.</dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Medicine, Universitas Diponegoro</dc:publisher>
	<dc:date>2026-04-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US"></dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ejournal2.undip.ac.id/index.php/jbtr/article/view/28945</dc:identifier>
	<dc:identifier>10.14710/jbtr.v12i1.28945</dc:identifier>
	<dc:source xml:lang="en-US">Journal of Biomedicine and Translational Research; Vol 12, No 1 (2026): April 2026; 7-13</dc:source>
	<dc:source>2503-2178</dc:source>
	<dc:source>10.14710/jbtr.v12i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ejournal2.undip.ac.id/index.php/jbtr/article/view/28945/14189</dc:relation>
	<dc:relation>https://ejournal2.undip.ac.id/index.php/jbtr/article/downloadSuppFile/28945/7110</dc:relation>
	<dc:relation>https://ejournal2.undip.ac.id/index.php/jbtr/article/downloadSuppFile/28945/7844</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2026 Journal of Biomedicine and Translational Research</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by-sa/4.0</dc:rights>
</oai_dc:dc>