Melola Discovery

← Melola Discovery

Akses terbuka Jurnal SINTA 1

The Effect of Liprotide-Encapsulated Vitamin D3 on MDA and SOD in Rats Deficient Vitamin D and Calcium

Journal of Biomedicine and Translational Research · Vol. 9 No. 1 (2023) · hlm. 1–6

DOI
10.14710/jbtr.v9i1.16289
ISSN
2503-2178
Terbit
2023-04-29
Penerbit
Faculty of Medicine, Universitas Diponegoro
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-sa/4.0

Abstrak

Background: Vitamin D deficiency is frequently correlated with elevated malondialdehyde (MDA) levels and decreased superoxide dismutase (SOD) activity. Several studies have demonstrated that vitamin D3 can reverse intracellular oxidative stress. However, vitamin D is prone to deterioration and instability. Liprotides contain lipids and proteins that can prevent vitamin D from oxidating.Objective: This study aims to investigate the effects of liprotide-encapsulated vitamin D3 on MDA concentrations and SOD activity in calcium and vitamin D-deficient rat models.Methods: The experimental post-test-only control group study used 24 Wistar rats randomly in 4 groups. Groups K(-), K(+), and P were fed a vitamin D and calcium-depleted AIN-93M diet for 14 days. Standard feed AIN-93M was received by normal groups (KN). Groups K- were deficient rats in vitamin D and calcium without intervention. The groups of K+ and P were given vitamin D3 (180 IU) which was non-encapsulated and liprotide-encapsulated for 28 days.The SOD activity was quantified with Superoxide Dismutase (SOD) Activity Assay Kit, while MDA levels were determined using Thiobarbituric Acid Reactive Substance (TBARS) method. The statistical analysis used One-way ANOVA test with Least Significant Difference follow-up test.Results: The MDA levels and SOD activity in the K+ and P groups had significant differences (p<0.05) against the control group. Liprotides-encapsulated vitamin D3 significantly reduced MDA levels and enhanced SOD activity compared to non-encapsulated in rats with a deficiency in vitamin D and calcium.Conclusion: Liprotide-encapsulated vitamin D3 has the potential to increase SOD activity and decrease MDA levels.

Kata kunci

Jaringan kolaborasi para penulis

40 penulis · 156 tautan kepenulisan bersama · 36 lintas organisasi · menampilkan 40 yang paling banyak terhubung

Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.

  • Diponegoro University
  • National Research and Innovation Agency
  • Universitas Ahmad Dahlan
  • International Islamic University Malaysia
  • University of Auckland
  • Universitas Kusuma Husada Surakarta
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
  • Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel
Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Etika Ratna NoerDiponegoro University10
Diana Nur AfifahDiponegoro University8
Muflihatul MunirohDiponegoro University5
Nani MaharaniDiponegoro University4
Ahmad SyauqyDiponegoro University3
Nina RestiDiponegoro University2
Fillah Fithra DienyDiponegoro University2
Amalia Rani SetyawatiDiponegoro University2
Mohammad SulchanDiponegoro University2
Helvi Desi MambayaDiponegoro University2
R.A. KusumaDiponegoro University2
Choirun NissaDiponegoro University2
Hery Djagat PurnomoDiponegoro University2
Kezia Yunandra KurniawanDiponegoro University2
Abdul RizalAfiliasi tidak diketahui1
M Agung Sapi’iAfiliasi tidak diketahui1
Miftahul AdnanDiponegoro University1
Hardhono SusantoDiponegoro University1
Sumardi WidodoDiponegoro University1
Karinda Kennia AntikaDiponegoro University1
Maria MexitaliaDiponegoro University1
Irwandi JaswirInternational Islamic University Malaysia1
Dewi Marfu’ah KurniawatiDiponegoro University1
Ayu RahadiyantiDiponegoro University1
Elia Nawang NursariDiponegoro University1
Nuryanto NuryantoDiponegoro University1
Fitriyono AyustaningwarnoDiponegoro University1
Ekowati ChasanahNational Research and Innovation Agency1
Endang Yuli PurwaniNational Research and Innovation Agency1
Fan ZhuUniversity of Auckland1
Sophia RoseUniversitas Kusuma Husada Surakarta1
Apoina KartiniDiponegoro University1
Iftitan Setya WidayantiDiponegoro University1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) https://ejournal2.undip.ac.id/index.php/jbtr/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">The Effect of Liprotide-Encapsulated Vitamin D3 on MDA and SOD in Rats Deficient Vitamin D and Calcium</dc:title>
	<dc:creator>Untari, Untari</dc:creator>
	<dc:creator>Anjani, Gemala</dc:creator>
	<dc:creator>Fulyani, Faizah</dc:creator>
	<dc:creator>Pramono, Adriyan</dc:creator>
	<dc:creator>Mahati, Endang</dc:creator>
	<dc:creator>Putri, Sylvia Rahmi</dc:creator>
	<dc:creator>Maulana, Reza Achmad</dc:creator>
	<dc:subject xml:lang="en-US">Vitamin D3; nanoencapsulation; liprotides; MDA; SOD</dc:subject>
	<dc:description xml:lang="en-US">Background: Vitamin D deficiency is frequently correlated with elevated malondialdehyde (MDA) levels and decreased superoxide dismutase (SOD) activity. Several studies have demonstrated that vitamin D3 can reverse intracellular oxidative stress. However, vitamin D is prone to deterioration and instability. Liprotides contain lipids and proteins that can prevent vitamin D from oxidating.Objective: This study aims to investigate the effects of liprotide-encapsulated vitamin D3 on MDA concentrations and SOD activity in calcium and vitamin D-deficient rat models.Methods: The experimental post-test-only control group study used 24 Wistar rats randomly in 4 groups. Groups K(-), K(+), and P were fed a vitamin D and calcium-depleted AIN-93M diet for 14 days. Standard feed AIN-93M was received by normal groups (KN). Groups K- were deficient rats in vitamin D and calcium without intervention. The groups of  K+ and P were given vitamin D3 (180 IU) which was non-encapsulated and liprotide-encapsulated for 28 days.The SOD activity was quantified with Superoxide Dismutase (SOD) Activity Assay Kit, while MDA levels were determined using Thiobarbituric Acid Reactive Substance (TBARS) method. The statistical analysis used One-way ANOVA test with Least Significant Difference follow-up test.Results: The MDA levels and SOD activity in the K+ and P groups had significant differences (p&lt;0.05) against the control group. Liprotides-encapsulated vitamin D3 significantly reduced MDA levels and enhanced SOD activity compared to non-encapsulated in rats with a deficiency in vitamin D and calcium.Conclusion: Liprotide-encapsulated vitamin D3 has the potential to increase SOD activity and decrease MDA levels. </dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Medicine, Universitas Diponegoro</dc:publisher>
	<dc:date>2023-04-29</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US"></dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ejournal2.undip.ac.id/index.php/jbtr/article/view/16289</dc:identifier>
	<dc:identifier>10.14710/jbtr.v9i1.16289</dc:identifier>
	<dc:source xml:lang="en-US">Journal of Biomedicine and Translational Research; Vol 9, No 1 (2023): April 2023; 1-6</dc:source>
	<dc:source>2503-2178</dc:source>
	<dc:source>10.14710/jbtr.v9i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ejournal2.undip.ac.id/index.php/jbtr/article/view/16289/8809</dc:relation>
	<dc:relation>https://ejournal2.undip.ac.id/index.php/jbtr/article/downloadSuppFile/16289/4014</dc:relation>
	<dc:relation>https://ejournal2.undip.ac.id/index.php/jbtr/article/downloadSuppFile/16289/4015</dc:relation>
	<dc:relation>https://ejournal2.undip.ac.id/index.php/jbtr/article/downloadSuppFile/16289/4424</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2023 Journal of Biomedicine and Translational Research</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by-sa/4.0</dc:rights>
</oai_dc:dc>