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Delayed Puberty in Girls with Primary Amenorrhea: A Report of Cases

Journal of Biomedicine and Translational Research · Vol. 7 No. 2 (2021) · hlm. 92–96

DOI
10.14710/jbtr.v7i2.12054
ISSN
2503-2178
Terbit
2021-08-31
Penerbit
Faculty of Medicine, Universitas Diponegoro
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-sa/4.0

Abstrak

Background:Female puberty starts when the pituitary hormone producing follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which will stimulate the ovaries to produce estrogen. Delayed puberty with primary amenorrhea in female is the lack of breast development followed by the absence of menses 3 years after the initiation of breast development. Sex chromosomes have an important role in determining the sex, germ cell differentiation of foetus, and reproductive functions of an offspring, thus, sex chromosomal aberrations frequently cause primary amenorrheaCase presentation: We report two delayed puberty cases with the chief complain of primary amenorrhea. Both cases showed hypoplasia of uterus and ovaries on pelvic imaging and hormonal assay showed low of FSH. The first case was gonadal dysgenesis with 46,XX karyotype and low level of estrogen and the second case was a turner syndrome with 45,X karyotype and normal level of estrogen. Conclusion:This study reported delayed puberty with primary amenorrhea cases due to different chromosomal aberration pattern which have similar clinical features. Therefore, cytogenetic examination is needed for any primary amenorrhea cases in order to accomplish the confirmatory diagnosis and for the clinicians to make a correct intervention and treatment.

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  • Diponegoro University
  • Dr. Kariadi Hospital
  • National Nuclear Energy Agency of Indonesia
  • Yarsi University
  • Universitas Wahid Hasyim
  • Tanjungpura University
  • Padjadjaran University
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Rekan penulisOrganisasiArtikel bersama
Agustini UtariDiponegoro University6
Nurin Aisyiyah ListyasariDiponegoro University5
Annastasia EdiatiDiponegoro University4
Iit FitrianingrumTanjungpura University3
Nydia Rena Benita SihombingDiponegoro University3
Ardy SantosaDr. Kariadi Hospital2
Achmad Zulfa JuniartoDiponegoro University2
J. JamariDiponegoro University2
Mohamad Izzur MaulaDiponegoro University2
M. Danny Pratama LamuraDiponegoro University2
Hasyid Ahmad WicaksonoDiponegoro University2
Elsa GusriantiDiponegoro University2
Ani Melani MaskoenPadjadjaran University2
Bremmy LaksonoDiponegoro University2
Syarief TaufikDiponegoro University2
Nani MaharaniDiponegoro University2
Maria BelladonnaDiponegoro University2
Noor PramonoDiponegoro University2
Mukh SyaifudinNational Nuclear Energy Agency of Indonesia1
Yanti LusiyantiNational Nuclear Energy Agency of Indonesia1
Dwi RamadhaniNational Nuclear Energy Agency of Indonesia1
Rianti MustikaraniDr. Kariadi Hospital1
Widjiati WidjiatiUniversitas Airlangga1
Oktoria IndraprajaDiponegoro University1
Noor Pramono NoerpramanaDiponegoro University1
Hery Djagat PurnomoDiponegoro University1
Rayvita AN MeagratiaDiponegoro University1
Ferdy Kurniawan CayamiDiponegoro University1
Udin BahrudinDiponegoro University1
Wiwik LestariDiponegoro University1
Muhammad Hussein GasemDiponegoro University1
Nur FarhanahDr. Kariadi Hospital1
Mentari AmirYarsi University1
Siti Farhanah AuliaYarsi University1
Octaviani Indrasari RanakusumaYarsi University1

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Sumber metadata: OAI-PMH (metadata jurnal) https://ejournal2.undip.ac.id/index.php/jbtr/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Delayed Puberty in Girls with Primary Amenorrhea: A Report of Cases</dc:title>
	<dc:creator>Shahab, Fatinah</dc:creator>
	<dc:creator>Mulyantoro, Inu</dc:creator>
	<dc:creator>Tjahjanto, Hary</dc:creator>
	<dc:creator>Winarni, Tri Indah</dc:creator>
	<dc:creator>Faradz, Sultana MH</dc:creator>
	<dc:subject xml:lang="en-US">Delayed Puberty; Primary Amenorrhea; Cytogenetic.</dc:subject>
	<dc:description xml:lang="en-US">Background:Female puberty starts when the pituitary hormone producing follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which will stimulate the ovaries to produce estrogen. Delayed puberty with primary amenorrhea in female is the lack of breast development followed by the absence of menses 3 years after the initiation of breast development. Sex chromosomes have an important role in determining the sex, germ cell differentiation of foetus, and reproductive functions of an offspring, thus, sex chromosomal aberrations frequently cause primary amenorrheaCase presentation: We report two delayed puberty cases with the chief complain of primary amenorrhea. Both cases showed hypoplasia of uterus and ovaries on pelvic imaging and hormonal assay showed low of FSH. The first case was gonadal dysgenesis with 46,XX karyotype and low level of estrogen and the second case was a turner syndrome with 45,X karyotype and normal level of estrogen. Conclusion:This study reported delayed puberty with primary amenorrhea cases due to different chromosomal aberration pattern which have similar clinical features. Therefore, cytogenetic examination is needed for any primary amenorrhea cases in order to accomplish the confirmatory diagnosis and for the clinicians to make a correct intervention and treatment. </dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Medicine, Universitas Diponegoro</dc:publisher>
	<dc:date>2021-08-31</dc:date>
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	<dc:identifier>10.14710/jbtr.v7i2.12054</dc:identifier>
	<dc:source xml:lang="en-US">Journal of Biomedicine and Translational Research; Vol 7, No 2 (2021): August 2021; 92-96</dc:source>
	<dc:source>2503-2178</dc:source>
	<dc:source>10.14710/jbtr.v7i2</dc:source>
	<dc:language>eng</dc:language>
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	<dc:rights xml:lang="en-US">Copyright (c) 2021 Journal of Biomedicine and Translational Research</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by-sa/4.0</dc:rights>
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