Melola Discovery

← Melola Discovery

Akses terbuka Jurnal SINTA 1

Effect of Probiotic Supplementation on FSH, LH Levels and Folliculogenesis

Journal of Biomedicine and Translational Research · Vol. 9 No. 1 (2023) · hlm. 19–24

DOI
10.14710/jbtr.v9i1.16824
ISSN
2503-2178
Terbit
2023-04-29
Penerbit
Faculty of Medicine, Universitas Diponegoro
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-sa/4.0

Abstrak

Background: Polycystic ovary syndrome (PCOS) is an endocrine disorder that often occurs in women of reproductive age. The main therapy currently used to treat PCOS patients is insulin sensitizer. In PCOS, there is an imbalance in the intestinal flora which causes activation of the immune system and an inflammatory response that leads to insulin resistance. The effect of probiotic supplementation on insulin resistance can have an impact on changes in reproductive hormone levels in PCOS women. Objective: Analyze the effect of probiotic supplementation on levels of FSH, LH, and folliculogenesis in a study of PCOS Wistar rats. Methods: Experimental research with a post-test only controlled group design. The research sample was 35 Wistar rats which were divided into 5 groups, (K-) were healthy rats, (K+) were PCOS rats without treatment, (P1) were PCOS rats received Metformin, (P2) were PCOS rats received Probiotics, and (P3) were PCOS rats that received Metformin + Probiotics. The intervention was carried out for 14 days. The dependent variables were levels of FSH, LH and folliculogenesis. Research data were analyzed using one-way ANOVA test, Fisher Exact test. Differences between groups and controls were tested with Dunnett's post hoc test. Significant p<0.05Results: Metformin + probiotic supplementation resulted in increased FSH levels, decreased LH levels and increased folliculogenesis when compared to the PCOS rats without treatment (K+).Conclusion: Metformin + probiotic supplementation causes levels of FSH, LH and folliculogenesis activity in PCOS rats to resemble healthy rats.

Kata kunci

Jaringan kolaborasi para penulis

22 penulis · 52 tautan kepenulisan bersama · 19 lintas organisasi

Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.

  • Diponegoro University
  • IPB University
  • Kementerian Kesehatan Republik Indonesia
  • Universitas Airlangga
  • State University of Semarang
  • National Research and Innovation Agency
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
  • Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel
Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Widjiati WidjiatiUniversitas Airlangga2
Diana NurrohimaKementerian Kesehatan Republik Indonesia1
Fifi LuthfiyahKementerian Kesehatan Republik Indonesia1
Qonita Nur QolbyState University of Semarang1
Nani MaharaniDiponegoro University1
Muflihatul MunirohDiponegoro University1
Julian DewantiningrumDiponegoro University1
Eka Djatnika NugrahaNational Research and Innovation Agency1
Sri Anna MarliyatiIPB University1
Faisal AnwarIPB University1
Muhammad Rizal Martua DamanikIPB University1
Seindy GlamourDiponegoro University1
Adi Setyawan PriantoDiponegoro University1
Noor PramonoDiponegoro University1
Yuli TrisetiyonoDiponegoro University1
Herman KristantoDiponegoro University1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) https://ejournal2.undip.ac.id/index.php/jbtr/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Effect of Probiotic Supplementation on FSH, LH Levels and Folliculogenesis</dc:title>
	<dc:creator>Rahman, Nur</dc:creator>
	<dc:creator>Hidayat, Syarief Thaufik</dc:creator>
	<dc:creator>Adi Pramono, Besari</dc:creator>
	<dc:creator>Soerjo Hadijono, Raden</dc:creator>
	<dc:creator>Oerip Poerwoko, Agoes</dc:creator>
	<dc:creator>Anityo Mochtar, Arufiadi</dc:creator>
	<dc:subject xml:lang="en-US">PCOS; Metformin; Probiotic; LH; FSH; Folliculogenesis</dc:subject>
	<dc:description xml:lang="en-US">Background: Polycystic ovary syndrome (PCOS) is an endocrine disorder that often occurs in women of reproductive age. The main therapy currently used to treat PCOS patients is insulin sensitizer. In PCOS, there is an imbalance in the intestinal flora which causes activation of the immune system and an inflammatory response that leads to insulin resistance. The effect of probiotic supplementation on insulin resistance can have an impact on changes in reproductive hormone levels in PCOS women. Objective: Analyze the effect of probiotic supplementation on levels of FSH, LH, and folliculogenesis in a study of PCOS Wistar rats. Methods: Experimental research with a post-test only controlled group design. The research sample was 35 Wistar rats which were divided into 5 groups, (K-) were healthy rats, (K+) were PCOS rats without treatment, (P1) were PCOS rats received Metformin, (P2) were PCOS rats received Probiotics, and (P3) were PCOS rats that received Metformin + Probiotics. The intervention was carried out for 14 days. The dependent variables were levels of FSH, LH and folliculogenesis. Research data were analyzed using one-way ANOVA test, Fisher Exact test. Differences between groups and controls were tested with Dunnett's post hoc test. Significant p&lt;0.05Results: Metformin + probiotic supplementation resulted in increased FSH levels, decreased LH levels and increased folliculogenesis when compared to the PCOS rats without treatment (K+).Conclusion: Metformin + probiotic supplementation causes levels of FSH, LH and folliculogenesis activity in PCOS rats to resemble healthy rats.</dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Medicine, Universitas Diponegoro</dc:publisher>
	<dc:date>2023-04-29</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US"></dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ejournal2.undip.ac.id/index.php/jbtr/article/view/16824</dc:identifier>
	<dc:identifier>10.14710/jbtr.v9i1.16824</dc:identifier>
	<dc:source xml:lang="en-US">Journal of Biomedicine and Translational Research; Vol 9, No 1 (2023): April 2023; 19-24</dc:source>
	<dc:source>2503-2178</dc:source>
	<dc:source>10.14710/jbtr.v9i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ejournal2.undip.ac.id/index.php/jbtr/article/view/16824/8810</dc:relation>
	<dc:relation>https://ejournal2.undip.ac.id/index.php/jbtr/article/downloadSuppFile/16824/4495</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2023 Journal of Biomedicine and Translational Research</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by-sa/4.0</dc:rights>
</oai_dc:dc>