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Stress-driven metabolic adaptation of Passiflora foetida L. root across coal mine reclamation ages: Linking soil chemistry, metabolomics and bioactivity
Journal of Degraded and Mining Lands Management · Vol. 13 No. 4 (2026) · hlm. 11185–11199
- ISSN
- 2502-2458, 2339-076X
- Terbit
- 2026-10-01
- Penerbit
- Brawijaya University
- Bahasa
- eng
Abstrak
Coal reclamation sites, characterized by low pH and high heavy metal concentrations, serve as invaluable stress laboratories. Plants growing in these environments are forced to upregulate secondary metabolic pathways as a defense mechanism against oxidative stress. This stress condition makes the flora of coal reclamation sites a more concentrated source of bioactive compounds than plants in normal soil. This study profiled the bioactive compounds and analyzed the biological activity of Passiflora foetida L. root extracts based on the age of the reclamation site. The ethanol extracts from P. foetida plants were fractionated to identify the bioactive compounds. The bioactive compound profile was determined using LC-QTOF-MS-based untargeted detection methods, while the biological activity analysis included the evaluation of antioxidant and antimicrobial properties in each obtained fraction. Chemical profiling revealed highly significant differences in compound composition among the various sample types. Across all bioassays, the ethyl acetate fraction from the reclamation sample was consistently the most active, confirming that semi-polar alkaloids, flavonoids, and terpenoids are the dominant pharmacophore classes in the root extracts of P. foetida. Analysis of the abundance of compounds produced in response to stress at the reclamation site indicates pharmacological potential, supporting the value of plant material from both locations as a source of bioactive natural products. This demonstrates the significant potential of the downstream processing of former mining sites into promising sources of natural medicines.
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- University of Brawijaya
- Universitas Mulia
- Institut Pertanian Malang
- Ahi Evran University
- Universitas Maarif Hasyim Latif
- North Carolina Agricultural and Technical State University
- Universitas Ibrahimy
- Organisasi lain
- Afiliasi tidak diketahui
- Organisasi berbeda
- Organisasi sama
- Afiliasi tidak diketahui
- Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel
Tampilkan sebagai tabel
| Rekan penulis | Organisasi | Artikel bersama |
|---|---|---|
| Yoga Dwi Jatmiko | University of Brawijaya | 2 |
| Sutrisno Sutrisno | University of Brawijaya | 2 |
| Izaz Aqeiluz Zahara | University of Brawijaya | 2 |
| Nabila Fitri Rosyida | Afiliasi tidak diketahui | 1 |
| Amin Setyo Leksono | University of Brawijaya | 1 |
| Anisa Zairina | Institut Pertanian Malang | 1 |
| Nia Kurniawan | University of Brawijaya | 1 |
| Wildania Putri Agustina | University of Brawijaya | 1 |
| Marsa Salsabila | University of Brawijaya | 1 |
| Riska Putri Qurotaayunina | University of Brawijaya | 1 |
| Hakan Bozdoğan | Ahi Evran University | 1 |
| Suharjono Suharjono | University of Brawijaya | 1 |
| Evi Octaviany | University of Brawijaya | 1 |
| Elsa Mega Suryani | Universitas Maarif Hasyim Latif | 1 |
| Hikmah Maulidiyah | University of Brawijaya | 1 |
| Salam Adnan Ibrahim | North Carolina Agricultural and Technical State University | 1 |
| Momodou Salieu Sowe | University of Brawijaya | 1 |
| Arda Rista Lestari | University of Brawijaya | 1 |
| Eka Novitasari | University of Brawijaya | 1 |
| Masruri Masruri | University of Brawijaya | 1 |
| Yuniar Ponco Prananto | University of Brawijaya | 1 |
| Ahmad Sholeh Romdlon | University of Brawijaya | 1 |
| Dian Siswanto | University of Brawijaya | 1 |
| Idham Halil Zakaria | University of Brawijaya | 1 |
| Arie Srihardyastutie | University of Brawijaya | 1 |
| Anna Roosdiana | University of Brawijaya | 1 |
| Aulanni’am Aulanni’am | University of Brawijaya | 1 |
| Eva Nur Laili Octaviana | University of Brawijaya | 1 |
| Dewi Ratih Tirto Sari | Universitas Ibrahimy | 1 |
| Fatchiyah Fatchiyah | University of Brawijaya | 1 |
| James R. Ketudat Cairns | Suranaree University of Technology | 1 |
| Rodiyati Azrianingsih | University of Brawijaya | 1 |
| Afifah Nur Aini | University of Brawijaya | 1 |
| Endang Arisoesilaningsih | University of Brawijaya | 1 |
| Durrotul Inayah | University of Brawijaya | 1 |
| Viky Vidayanti | University of Brawijaya | 1 |
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